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(Q29819187)
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R2d2 Dmel_CG7138
Protein found in Drosophila melanogaster
CG7138 gene product from transcript CG7138-RA
CG7138-PC
r2d2
CG7138-PA
r2d2-PB
CG7138-PB
r2d2-PA
r2d2-PC
In more languages
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Statements
instance of
protein
1 reference
stated in
UniProt
retrieved
25 May 2022
UniProt protein ID
Q9VLW8
part of
Double-stranded RNA-binding domain, protein family
1 reference
based on heuristic
inferred from protein domain or family
found in taxon
Drosophila melanogaster
1 reference
stated in
UniProt
retrieved
25 May 2022
UniProt protein ID
Q9VLW8
encoded by
r2d2
1 reference
stated in
UniProt
retrieved
25 May 2022
UniProt protein ID
Q9VLW8
molecular function
RNA binding
determination method
IEA
1 reference
retrieved
16 July 2018
stated in
GOA
curator
UniProt
UniProt protein ID
Q9VLW8
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9VLW8&geneProductId=UniProtKB:Q9VLW8
determination method
IEA
double-stranded RNA binding
determination method
ISS
1 reference
retrieved
16 July 2018
stated in
The drosophila melanogaster genome: translation factors and RNA binding proteins
GOA
curator
FlyBase
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9VLW8&geneProductId=UniProtKB:Q9VLW8
determination method
ISS
protein binding
determination method
IPI
1 reference
retrieved
16 July 2018
stated in
Dicer-1 and R3D1-L catalyze microRNA maturation in Drosophila
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9VLW8&geneProductId=UniProtKB:Q9VLW8
determination method
IPI
cell component
nucleus
determination method
IDA
2 references
retrieved
16 July 2018
stated in
Drosophila R2D2 mediates follicle formation in somatic tissues through interactions with Dicer-1.
GOA
curator
FlyBase
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9VLW8&geneProductId=UniProtKB:Q9VLW8
determination method
IDA
retrieved
16 July 2018
stated in
TAF11 Assembles the RISC Loading Complex to Enhance RNAi Efficiency
GOA
curator
FlyBase
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9VLW8&geneProductId=UniProtKB:Q9VLW8
determination method
IDA
cytoplasm
determination method
IDA
2 references
retrieved
16 July 2018
stated in
Drosophila R2D2 mediates follicle formation in somatic tissues through interactions with Dicer-1.
GOA
curator
FlyBase
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9VLW8&geneProductId=UniProtKB:Q9VLW8
determination method
IDA
retrieved
16 July 2018
stated in
TAF11 Assembles the RISC Loading Complex to Enhance RNAi Efficiency
GOA
curator
FlyBase
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9VLW8&geneProductId=UniProtKB:Q9VLW8
determination method
IDA
RISC complex
determination method
IDA
1 reference
retrieved
16 July 2018
stated in
C3PO, an endoribonuclease that promotes RNAi by facilitating RISC activation
GOA
curator
FlyBase
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9VLW8&geneProductId=UniProtKB:Q9VLW8
determination method
IDA
RISC-loading complex
determination method
IPI
1 reference
retrieved
16 July 2018
stated in
The C-terminal dsRNA-binding domain of Drosophila Dicer-2 is crucial for efficient and high-fidelity production of siRNA and loading of siRNA to Argonaute2.
GOA
curator
FlyBase
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9VLW8&geneProductId=UniProtKB:Q9VLW8
determination method
IPI
biological process
production of siRNA involved in RNA interference
determination method
IDA
1 reference
retrieved
16 July 2018
stated in
Loqs and R2D2 act sequentially in the siRNA pathway in Drosophila
GOA
curator
FlyBase
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9VLW8&geneProductId=UniProtKB:Q9VLW8
determination method
IDA
ovarian follicle cell stalk formation
determination method
IMP
1 reference
retrieved
16 July 2018
stated in
Drosophila R2D2 mediates follicle formation in somatic tissues through interactions with Dicer-1.
GOA
curator
FlyBase
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9VLW8&geneProductId=UniProtKB:Q9VLW8
determination method
IMP
defense response to virus
determination method
IMP
3 references
retrieved
16 July 2018
stated in
RNA-based immunity terminates viral infection in adult Drosophila in the absence of viral suppression of RNA interference: characterization of viral small interfering RNA populations in wild-type and mutant flies
GOA
curator
FlyBase
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9VLW8&geneProductId=UniProtKB:Q9VLW8
determination method
IMP
retrieved
16 July 2018
stated in
RNA interference directs innate immunity against viruses in adult Drosophila
GOA
curator
FlyBase
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9VLW8&geneProductId=UniProtKB:Q9VLW8
determination method
IMP
retrieved
16 July 2018
stated in
RNAi-mediated immunity provides strong protection against the negative-strand RNA vesicular stomatitis virus in Drosophila
GOA
curator
FlyBase
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9VLW8&geneProductId=UniProtKB:Q9VLW8
determination method
IMP
production of small RNA involved in gene silencing by RNA
determination method
IDA
1 reference
retrieved
16 July 2018
stated in
Loqs and R2D2 act sequentially in the siRNA pathway in Drosophila
GOA
curator
FlyBase
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9VLW8&geneProductId=UniProtKB:Q9VLW8
determination method
IDA
regulation of production of small RNA involved in gene silencing by RNA
determination method
IDA
1 reference
retrieved
16 July 2018
stated in
Phosphate and R2D2 restrict the substrate specificity of Dicer-2, an ATP-driven ribonuclease
GOA
curator
FlyBase
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9VLW8&geneProductId=UniProtKB:Q9VLW8
determination method
IDA
has part(s)
Double-stranded RNA-binding domain
1 reference
stated in
InterPro Release 71.0
reference URL
http://www.ebi.ac.uk/interpro/protein/Q9VLW8
Identifiers
RefSeq protein ID
NP_001162903
1 reference
stated in
NCBI Gene
retrieved
20 March 2022
Entrez Gene ID
34066
NP_001285720
1 reference
stated in
NCBI Gene
retrieved
20 March 2022
Entrez Gene ID
34066
NP_609152
1 reference
stated in
NCBI Gene
retrieved
20 March 2022
Entrez Gene ID
34066
UniProt protein ID
Q9VLW8
1 reference
stated in
UniProt
retrieved
25 May 2022
UniProt protein ID
Q9VLW8
Ensembl protein ID
FBpp0310061
1 reference
stated in
ensembl Release 106
Ensembl protein ID
FBpp0310061
FBpp0290544
1 reference
stated in
ensembl Release 106
Ensembl protein ID
FBpp0290544
FBpp0079112
1 reference
stated in
ensembl Release 106
Ensembl protein ID
FBpp0079112
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