(Q47070471)

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The C-terminal dsRNA-binding domain of Drosophila Dicer-2 is crucial for efficient and high-fidelity production of siRNA and loading of siRNA to Argonaute2.

scientific article published on 17 April 2017

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18 March 2020

The C-terminal dsRNA-binding domain of Drosophila Dicer-2 is crucial for efficient and high-fidelity production of siRNA and loading of siRNA to Argonaute2 (English)

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Europe PubMed Central

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18 March 2020

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R2d2 Dmel_CG7138

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GOA release 2020-03-11

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18 March 2020

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18 March 2020

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Suresh K Kandasamy

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18 March 2020

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18 March 2020

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18 March 2020

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18 March 2020

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18 March 2020

1139-1153

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18 March 2020

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Target RNA-directed tailing and trimming purifies the sorting of endo-siRNAs between the two Drosophila Argonaute proteins

1 reference

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21 January 2018

Role for a bidentate ribonuclease in the initiation step of RNA interference

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The long and short of antiviral defense: small RNA-based immunity in insects

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21 January 2018

Phosphate and R2D2 restrict the substrate specificity of Dicer-2, an ATP-driven ribonuclease

1 reference

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21 January 2018

An endogenous small interfering RNA pathway in Drosophila

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21 January 2018

Functional anatomy of siRNAs for mediating efficient RNAi in Drosophila melanogaster embryo lysate

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Host control of insect endogenous retroviruses: small RNA silencing and immune response

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A retrotransposon-driven dicer isoform directs endogenous small interfering RNA production in mouse oocytes

1 reference

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Drosophila microRNAs are sorted into functionally distinct argonaute complexes after production by dicer-1.

1 reference

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21 January 2018

A universal small molecule, inorganic phosphate, restricts the substrate specificity of Dicer-2 in small RNA biogenesis

1 reference

https://api.crossref.org/works/10.1261%2FRNA.059915.116

21 January 2018

Dicer partner proteins tune the length of mature miRNAs in flies and mammals

1 reference

https://api.crossref.org/works/10.1261%2FRNA.059915.116

21 January 2018

Inorganic phosphate blocks binding of pre-miRNA to Dicer-2 via its PAZ domain

1 reference

https://api.crossref.org/works/10.1261%2FRNA.059915.116

21 January 2018

Endogenous siRNAs derived from transposons and mRNAs in Drosophila somatic cells

1 reference

https://api.crossref.org/works/10.1261%2FRNA.059915.116

21 January 2018

The loop position of shRNAs and pre-miRNAs is critical for the accuracy of dicer processing in vivo

1 reference

https://api.crossref.org/works/10.1261%2FRNA.059915.116

21 January 2018

Noncoding RNA. piRNA-guided transposon cleavage initiates Zucchini-dependent, phased piRNA production

1 reference

https://api.crossref.org/works/10.1261%2FRNA.059915.116

21 January 2018

piPipes: a set of pipelines for piRNA and transposon analysis via small RNA-seq, RNA-seq, degradome- and CAGE-seq, ChIP-seq and genomic DNA sequencing

1 reference

https://api.crossref.org/works/10.1261%2FRNA.059915.116

21 January 2018

Loqs-PD and R2D2 define independent pathways for RISC generation in Drosophila.

1 reference

https://api.crossref.org/works/10.1261%2FRNA.059915.116

21 January 2018

A cellular function for the RNA-interference enzyme Dicer in the maturation of the let-7 small temporal RNA

1 reference

https://api.crossref.org/works/10.1261%2FRNA.059915.116

21 January 2018

Phosphate-binding pocket in Dicer-2 PAZ domain for high-fidelity siRNA production.

1 reference

https://api.crossref.org/works/10.1261%2FRNA.059915.116

21 January 2018

RNAi and antiviral defense in Drosophila: setting up a systemic immune response

1 reference

https://api.crossref.org/works/10.1261%2FRNA.059915.116

21 January 2018

Drosophila endogenous small RNAs bind to Argonaute 2 in somatic cells

1 reference

https://api.crossref.org/works/10.1261%2FRNA.059915.116

21 January 2018

Production of functional small interfering RNAs by an amino-terminal deletion mutant of human Dicer

1 reference

https://api.crossref.org/works/10.1261%2FRNA.059915.116

21 January 2018

Dicer functions in RNA interference and in synthesis of small RNA involved in developmental timing in C. elegans

1 reference

https://api.crossref.org/works/10.1261%2FRNA.059915.116

21 January 2018

A role for the RNase III enzyme DCR-1 in RNA interference and germ line development in Caenorhabditis elegans

1 reference

https://api.crossref.org/works/10.1261%2FRNA.059915.116

21 January 2018

The molecular architecture of human Dicer

1 reference

https://api.crossref.org/works/10.1261%2FRNA.059915.116

21 January 2018

Making a better RNAi vector for Drosophila: use of intron spacers

1 reference

https://api.crossref.org/works/10.1261%2FRNA.059915.116

21 January 2018

Distinct roles for Drosophila Dicer-1 and Dicer-2 in the siRNA/miRNA silencing pathways

1 reference

https://api.crossref.org/works/10.1261%2FRNA.059915.116

21 January 2018

R2D2, a Bridge Between the Initiation and Effector Steps of the Drosophila RNAi Pathway

1 reference

https://api.crossref.org/works/10.1261%2FRNA.059915.116

21 January 2018

Autoinhibition of human dicer by its internal helicase domain

1 reference

https://api.crossref.org/works/10.1261%2FRNA.059915.116

21 January 2018

Structural basis for double-stranded RNA processing by Dicer

1 reference

https://api.crossref.org/works/10.1261%2FRNA.059915.116

21 January 2018

Structural determinants of RNA recognition and cleavage by Dicer

1 reference

https://api.crossref.org/works/10.1261%2FRNA.059915.116

21 January 2018

Slicer function of Drosophila Argonautes and its involvement in RISC formation

1 reference

https://api.crossref.org/works/10.1261%2FRNA.059915.116

21 January 2018

Characterization of the miRNA-RISC loading complex and miRNA-RISC formed in the Drosophila miRNA pathway

1 reference

https://api.crossref.org/works/10.1261%2FRNA.059915.116

21 January 2018

Roles of R2D2, a cytoplasmic D2 body component, in the endogenous siRNA pathway in Drosophila

1 reference

https://api.crossref.org/works/10.1261%2FRNA.059915.116

21 January 2018

Two distinct mechanisms generate endogenous siRNAs from bidirectional transcription in Drosophila melanogaster

1 reference

https://api.crossref.org/works/10.1261%2FRNA.059915.116

21 January 2018

The Drosophila hairpin RNA pathway generates endogenous short interfering RNAs

1 reference

https://api.crossref.org/works/10.1261%2FRNA.059915.116

21 January 2018

Functional small RNAs are generated from select miRNA hairpin loops in flies and mammals

1 reference

https://api.crossref.org/works/10.1261%2FRNA.059915.116

21 January 2018

Dicer recognizes the 5' end of RNA for efficient and accurate processing

1 reference

https://api.crossref.org/works/10.1261%2FRNA.059915.116

21 January 2018

Ribonuclease activity and RNA binding of recombinant human Dicer

1 reference

https://api.crossref.org/works/10.1261%2FRNA.059915.116

21 January 2018

Drosophila dicer-2 cleavage is mediated by helicase- and dsRNA termini-dependent states that are modulated by Loquacious-PD.

1 reference

https://api.crossref.org/works/10.1261%2FRNA.059915.116

21 January 2018

Substrate-specific structural rearrangements of human Dicer

1 reference

https://api.crossref.org/works/10.1261%2FRNA.059915.116

21 January 2018

Recognition of the pre-miRNA structure by Drosophila Dicer-1.

1 reference

https://api.crossref.org/works/10.1261%2FRNA.059915.116

21 January 2018

Dicer's helicase domain discriminates dsRNA termini to promote an altered reaction mode

1 reference

https://api.crossref.org/works/10.1261%2FRNA.059915.116

21 January 2018

The role of human Dicer-dsRBD in processing small regulatory RNAs

1 reference

https://api.crossref.org/works/10.1261%2FRNA.059915.116

21 January 2018

Biological mechanisms determining the success of RNA interference in insects

1 reference

https://api.crossref.org/works/10.1261%2FRNA.059915.116

21 January 2018

Functional anatomy of the Drosophila microRNA-generating enzyme

1 reference

https://api.crossref.org/works/10.1261%2FRNA.059915.116

21 January 2018

Single processing center models for human Dicer and bacterial RNase III

1 reference

https://api.crossref.org/works/10.1261%2FRNA.059915.116

21 January 2018

Identifiers

10.1261/RNA.059915.116

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28416567%20AND%20SRC:MED&resulttype=core&format=json

18 March 2020

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28416567%20AND%20SRC:MED&resulttype=core&format=json

18 March 2020

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28416567%20AND%20SRC:MED&resulttype=core&format=json

18 March 2020

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