(Q30164525)

9 June 2017

CrkII induces serum response factor activation and cellular transformation through its function in Rho activation (English)

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9 June 2017

Toshinori Iwahara

1

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9 June 2017

Tsuyoshi Akagi

series ordinal

2

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9 June 2017

Tomoyuki Shishido

series ordinal

3

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9 June 2017

Hidesaburo Hanafusa

series ordinal

4

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9 June 2017

language of work or name

English

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publication date

1 September 2003

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9 June 2017

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9 June 2017

22

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9 June 2017

38

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9 June 2017

5946-5957

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v-Crk activates the phosphoinositide 3-kinase/AKT pathway in transformation

9 June 2017

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206633

Tyrosine phosphorylation of p130(cas) by bombesin, lysophosphatidic acid, phorbol esters, and platelet-derived growth factor. Signaling pathways and formation of a p130(cas)-Crk complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206633

c-Src regulates the simultaneous rearrangement of actin cytoskeleton, p190RhoGAP, and p120RasGAP following epidermal growth factor stimulation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206633

Regulation of cell contraction and membrane ruffling by distinct signals in migratory cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206633

Regulation of G protein-linked guanine nucleotide exchange factors for Rho, PDZ-RhoGEF, and LARG by tyrosine phosphorylation: evidence of a role for focal adhesion kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206633

Extracellular-regulated kinase activation and CAS/Crk coupling regulate cell migration and suppress apoptosis during invasion of the extracellular matrix

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206633

Galpha12 stimulates c-Jun NH2-terminal kinase through the small G proteins Ras and Rac.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206633

The adaptor protein Crk connects multiple cellular stimuli to the JNK signaling pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206633

The small GTP-binding protein Rho links G protein-coupled receptors and Galpha12 to the serum response element and to cellular transformation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206633

A novel PDZ domain containing guanine nucleotide exchange factor links heterotrimeric G proteins to Rho

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206633

The G-protein G13 but not G12 mediates signaling from lysophosphatidic acid receptor via epidermal growth factor receptor to Rho.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206633

RhoA stimulates p27(Kip) degradation through its regulation of cyclin E/CDK2 activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206633

CrkII signals from epidermal growth factor receptor to Ras

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206633

CAS/Crk coupling serves as a "molecular switch" for induction of cell migration

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206633

Specific contributions of the small GTPases Rho, Rac, and Cdc42 to Dbl transformation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206633

v-src-induced cell shape changes in rat fibroblasts require new gene transcription and precede loss of focal adhesions

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206633

pEF-BOS, a powerful mammalian expression vector

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206633

The functional role of CrkII in actin cytoskeleton organization and mitogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206633

Activation of Jun kinase/stress-activated protein kinase by GTPase-deficient mutants of G alpha 12 and G alpha 13.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206633

The CRKL adaptor protein transforms fibroblasts and functions in transformation by the BCR-ABL oncogene

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206633

G13alpha-mediated PYK2 activation. PYK2 is a mediator of G13alpha -induced serum response element-dependent transcription.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206633

The v-Crk oncogene enhances cell survival and induces activation of protein kinase B/Akt.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206633

Downstream of Crk adaptor signaling pathway: activation of Jun kinase by v-Crk through the guanine nucleotide exchange protein C3G.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206633

Galpha12 and Galpha13 regulate extracellular signal-regulated kinase and c-Jun kinase pathways by different mechanisms in COS-7 cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206633

A mutant alpha subunit of G12 potentiates the eicosanoid pathway and is highly oncogenic in NIH 3T3 cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206633

Structural basis for relief of autoinhibition of the Dbl homology domain of proto-oncogene Vav by tyrosine phosphorylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206633

7 January 2021

Characterization of peripheral blood T-lymphocytes transduced with HTLV-I Tax mutants with different trans-activating phenotypes.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206633

7 January 2021

Integrin engagement suppresses RhoA activity via a c-Src-dependent mechanism

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206633

7 January 2021

Mad proteins contain a dominant transcription repression domain.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206633

7 January 2021

SH2 and SH3-containing adaptor proteins: redundant or independent mediators of intracellular signal transduction.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206633

7 January 2021

p190 RhoGAP is the principal Src substrate in brain and regulates axon outgrowth, guidance and fasciculation

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206633

7 January 2021

Signal transduction by the JNK group of MAP kinases

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206633

7 January 2021

Crk family adaptors-signalling complex formation and biological roles

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206633

7 January 2021

Leukemia-associated Rho guanine nucleotide exchange factor (LARG) links heterotrimeric G proteins of the G(12) family to Rho

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206633

7 January 2021

Phosphorylation of transcription factor p62TCF by MAP kinase stimulates ternary complex formation at c-fos promoter

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206633

7 January 2021

Identification of Rap1 as a target for the Crk SH3 domain-binding guanine nucleotide-releasing factor C3G

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206633

7 January 2021

Stimulation of 3T3 cells induces transcription of the c-fos proto-oncogene

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206633

7 January 2021

CED-12/ELMO, a novel member of the CrkII/Dock180/Rac pathway, is required for phagocytosis and cell migration

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206633

7 January 2021

Direct stimulation of the guanine nucleotide exchange activity of p115 RhoGEF by Galpha13

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206633

7 January 2021

Primary response genes induced by growth factors and tumor promoters

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206633

7 January 2021

Differential activation of c-fos promoter elements by serum, lysophosphatidic acid, G proteins and polypeptide growth factors.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206633

7 January 2021

The Rho family GTPases RhoA, Rac1, and CDC42Hs regulate transcriptional activation by SRF

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206633

7 January 2021

The transforming activity of activated G alpha 12.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206633

7 January 2021

Two pathways for serum regulation of the c-fos serum response element require specific sequence elements and a minimal domain of serum response factor

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206633

7 January 2021

Constitutively active Galpha12, Galpha13, and Galphaq induce Rho-dependent neurite retraction through different signaling pathways

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206633

7 January 2021

Activation of Rac1, RhoA, and mitogen-activated protein kinases is required for Ras transformation

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206633

7 January 2021

Activation of Rac1 by a Crk SH3-binding protein, DOCK180

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206633

7 January 2021

p115 RhoGEF, a GTPase activating protein for Galpha12 and Galpha13

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206633

7 January 2021

Activation of RhoA by lysophosphatidic acid and Galpha12/13 subunits in neuronal cells: induction of neurite retraction

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206633

7 January 2021

Csk, a critical link of g protein signals to actin cytoskeletal reorganization

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206633

7 January 2021

Tec/Bmx non-receptor tyrosine kinases are involved in regulation of Rho and serum response factor by Galpha12/13

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206633

7 January 2021

Specific involvement of G proteins in regulation of serum response factor-mediated gene transcription by different receptors

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206633

7 January 2021

Guanine nucleotide exchange factor GEF115 specifically mediates activation of Rho and serum response factor by the G protein alpha subunit Galpha13

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206633

7 January 2021

Two species of human CRK cDNA encode proteins with distinct biological activities

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206633

7 January 2021

A novel viral oncogene with structural similarity to phospholipase C

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206633

7 January 2021

Advanced mammalian gene transfer: high titre retroviral vectors with multiple drug selection markers and a complementary helper-free packaging cell line

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206633

7 January 2021

Plat-E: an efficient and stable system for transient packaging of retroviruses

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206633

7 January 2021

The Src family tyrosine kinase is involved in Rho-dependent activation of c-Jun N-terminal kinase by Galpha12.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206633

7 January 2021

Myoblast city, the Drosophila homolog of DOCK180/CED-5, is required in a Rac signaling pathway utilized for multiple developmental processes

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206633

7 January 2021

Signals from Ras and Rho GTPases interact to regulate expression of p21Waf1/Cip1.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206633

7 January 2021

The Crk signaling pathway contributes to the bombesin-induced activation of the small GTPase Rap1 in Swiss 3T3 cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206633

7 January 2021

Regulation of the small GTP-binding protein Rho by cell adhesion and the cytoskeleton

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206633

7 January 2021

Structural requirements for function of the Crkl adapter protein in fibroblasts and hematopoietic cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206633

7 January 2021

Crk family adaptor proteins trans-activate c-Abl kinase

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206633

7 January 2021

Apoptotic regulation by the Crk adapter protein mediated by interactions with Wee1 and Crm1/exportin

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206633

7 January 2021

Cooperative transformation of NIH3T3 cells by G alpha12 and Rac1.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206633

7 January 2021

Ternary complex factors: growth factor regulated transcriptional activators

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206633

7 January 2021

Regulation of transcription by MAP kinase cascades

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206633

7 January 2021

Timing of cyclin D1 expression within G1 phase is controlled by Rho.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206633

7 January 2021

Direct involvement of the small GTP-binding protein Rho in lbc oncogene function

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206633

7 January 2021

G2A is an oncogenic G protein-coupled receptor

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206633

7 January 2021

Identifiers

DOI

10.1038/SJ.ONC.1206633

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Dimensions Publication ID

9 June 2017

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1 reference