(Q30164638)

9 June 2017

Itk phosphorylation sites are required for functional activity in primary T cells (English)

1 reference

9 June 2017

1 reference

Heather M Wilcox

1

1 reference

PubMed ID

12842872

9 June 2017

Leslie J Berg

series ordinal

2

1 reference

PubMed ID

12842872

9 June 2017

language of work or name

English

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publication date

3 July 2003

1 reference

Journal of Biological Chemistry

9 June 2017

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9 June 2017

278

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9 June 2017

37112-37121

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9 June 2017

39

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Signal transduction by the TCR for antigen

9 June 2017

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M304811200

Lck phosphorylates the activation loop tyrosine of the Itk kinase domain and activates Itk kinase activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M304811200

Itk/Emt/Tsk activation in response to CD3 cross-linking in Jurkat T cells requires ZAP-70 and Lat and is independent of membrane recruitment

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M304811200

LAT: the ZAP-70 tyrosine kinase substrate that links T cell receptor to cellular activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M304811200

T cell receptor-initiated calcium release is uncoupled from capacitative calcium entry in Itk-deficient T cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M304811200

Defective Fas ligand expression and activation-induced cell death in the absence of IL-2-inducible T cell kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M304811200

A role for Bruton's tyrosine kinase in B cell antigen receptor-mediated activation of phospholipase C-gamma 2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M304811200

Analysis of signaling via surface immunoglobulin receptors on B cells from CBA/N mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M304811200

Btk/Tec kinases regulate sustained increases in intracellular Ca2+ following B-cell receptor activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M304811200

Tec family kinases in lymphocyte signaling and function

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M304811200

Regulatory intramolecular association in a tyrosine kinase of the Tec family

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M304811200

A specific intermolecular association between the regulatory domains of a Tec family kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M304811200

Posttranscriptional regulation of Bruton's tyrosine kinase expression in antigen receptor-stimulated splenic B cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M304811200

Regulation of Btk function by a major autophosphorylation site within the SH3 domain

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M304811200

Phosphorylation of two regulatory tyrosine residues in the activation of Bruton's tyrosine kinase via alternative receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M304811200

BAP-135, a target for Bruton's tyrosine kinase in response to B cell receptor engagement

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M304811200

Solution structure of the SH3 domain from Bruton's tyrosine kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M304811200

Intermolecular interactions between the SH3 domain and the proline-rich TH region of Bruton's tyrosine kinase.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M304811200

Biochemical interactions integrating Itk with the T cell receptor-initiated signaling cascade

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M304811200

Identification of Itk/Tsk Src homology 3 domain ligands

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M304811200

Transplantable myeloproliferative disease induced in mice by an interleukin 6 retrovirus

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M304811200

Peripheral expression of Jak3 is required to maintain T lymphocyte function

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M304811200

In situ detection of activated Bruton's tyrosine kinase in the Ig signaling complex by phosphopeptide-specific monoclonal antibodies

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M304811200

Activation of BTK by a phosphorylation mechanism initiated by SRC family kinases

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M304811200

Src-induced activation of inducible T cell kinase (ITK) requires phosphatidylinositol 3-kinase activity and the Pleckstrin homology domain of inducible T cell kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M304811200

PDGF stimulation of inositol phospholipid hydrolysis requires PLC-gamma 1 phosphorylation on tyrosine residues 783 and 1254.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M304811200

Association of Grb2, Gads, and phospholipase C-gamma 1 with phosphorylated LAT tyrosine residues. Effect of LAT tyrosine mutations on T cell angigen receptor-mediated signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M304811200

Regulation of Btk by Src family tyrosine kinases

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M304811200

A Btk transgene restores the antiviral TI-2 antibody responses of xid mice in a dose-dependent fashion

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M304811200

Btk dosage determines sensitivity to B cell antigen receptor cross-linking

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M304811200

Impaired NFATc translocation and failure of Th2 development in Itk-deficient CD4+ T cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M304811200

Deficiency of PTEN in Jurkat T cells causes constitutive localization of Itk to the plasma membrane and hyperresponsiveness to CD3 stimulation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M304811200

Altered T cell receptor signaling and disrupted T cell development in mice lacking Itk.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M304811200

The absence of Itk inhibits positive selection without changing lineage commitment

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M304811200

Tec family kinases modulate thresholds for thymocyte development and selection

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M304811200

The proline rich region of the Tec homology domain of ITK regulates its activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M304811200

The identification of conserved interactions within the SH3 domain by alignment of sequences and structures

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M304811200

Interaction of SLP adaptors with the SH2 domain of Tec family kinases

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M304811200

Essential role of LAT in T cell development

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M304811200

TCR/CD3-Induced activation and binding of Emt/Itk to linker of activated T cell complexes: requirement for the Src homology 2 domain.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M304811200

Bruton's tyrosine kinase activity is negatively regulated by Sab, the Btk-SH3 domain-binding protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M304811200

Competing modes of self-association in the regulatory domains of Bruton's tyrosine kinase: Intramolecular contact versus asymmetric homodimerization

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M304811200

21 January 2018

Identifiers

DOI

10.1074/JBC.M304811200

1 reference

9 June 2017

1 reference

PubMed ID

12842872