(Q30168876)

English

Identification of an atypical Grb2 carboxyl-terminal SH3 domain binding site in Gab docking proteins reveals Grb2-dependent and -independent recruitment of Gab1 to receptor tyrosine kinases

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scholarly article

1 reference

Europe PubMed Central

9 June 2017

Identification of an atypical Grb2 carboxyl-terminal SH3 domain binding site in Gab docking proteins reveals Grb2-dependent and -independent recruitment of Gab1 to receptor tyrosine kinases (English)

1 reference

Europe PubMed Central

9 June 2017

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author name string

Lock LS

1

1 reference

Europe PubMed Central

9 June 2017

Royal I

2

1 reference

Europe PubMed Central

9 June 2017

Naujokas MA

3

1 reference

Europe PubMed Central

9 June 2017

Park M

4

1 reference

Europe PubMed Central

9 June 2017

language of work or name

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publication date

1 October 2000

1 reference

Europe PubMed Central

9 June 2017

Journal of Biological Chemistry

1 reference

Europe PubMed Central

9 June 2017

275

1 reference

Europe PubMed Central

9 June 2017

31536-31545

1 reference

Europe PubMed Central

9 June 2017

40

1 reference

Europe PubMed Central

9 June 2017

Protein modules and signalling networks

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DOS, a novel pleckstrin homology domain-containing protein required for signal transduction between sevenless and Ras1 in Drosophila.

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Daughter of sevenless is a substrate of the phosphotyrosine phosphatase Corkscrew and functions during sevenless signaling

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p62(dok): a constitutively tyrosine-phosphorylated, GAP-associated protein in chronic myelogenous leukemia progenitor cells

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Identification of the Abl- and rasGAP-associated 62 kDa protein as a docking protein, Dok

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A lipid-anchored Grb2-binding protein that links FGF-receptor activation to the Ras/MAPK signaling pathway

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A Grb2-associated docking protein in EGF- and insulin-receptor signalling

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Cloning of p97/Gab2, the major SHP2-binding protein in hematopoietic cells, reveals a novel pathway for cytokine-induced gene activation

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Hepatocyte growth factor/scatter factor induces a variety of tissue-specific morphogenic programs in epithelial cells

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Purification of scatter factor, a fibroblast-derived basic protein that modulates epithelial interactions and movement

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Purification and characterization of a growth factor from rat platelets for mature parenchymal hepatocytes in primary cultures

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Scatter factor is a fibroblast-derived modulator of epithelial cell mobility

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The receptor encoded by the human c-MET oncogene is expressed in hepatocytes, epithelial cells and solid tumors

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Activating mutations for the met tyrosine kinase receptor in human cancer

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Tumorigenicity of the met proto-oncogene and the gene for hepatocyte growth factor

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Association of the multisubstrate docking protein Gab1 with the hepatocyte growth factor receptor requires a functional Grb2 binding site involving tyrosine 1356.

1 reference

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The Gab1 PH domain is required for localization of Gab1 at sites of cell-cell contact and epithelial morphogenesis downstream from the met receptor tyrosine kinase

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Met-induced JNK activation is mediated by the adapter protein Crk and correlates with the Gab1 - Crk signaling complex formation

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Interaction between Gab1 and the c-Met receptor tyrosine kinase is responsible for epithelial morphogenesis

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Efficient cellular transformation by the Met oncoprotein requires a functional Grb2 binding site and correlates with phosphorylation of the Grb2-associated proteins, Cbl and Gab1.

1 reference

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Branching tubulogenesis but not scatter of madin-darby canine kidney cells requires a functional Grb2 binding site in the Met receptor tyrosine kinase

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Interaction with the phosphotyrosine binding domain/phosphotyrosine interacting domain of SHC is required for the transforming activity of the FLT4/VEGFR3 receptor tyrosine kinase

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A novel positive feedback loop mediated by the docking protein Gab1 and phosphatidylinositol 3-kinase in epidermal growth factor receptor signaling

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Identification and analysis of PH domain-containing targets of phosphatidylinositol 3-kinase using a novel in vivo assay in yeast

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Gab1 coupling to the HGF/Met receptor multifunctional docking site requires binding of Grb2 and correlates with the transforming potential.

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Grb2-associated binder-1 mediates phosphatidylinositol 3-kinase activation and the promotion of cell survival by nerve growth factor

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Gab1 acts as an adapter molecule linking the cytokine receptor gp130 to ERK mitogen-activated protein kinase

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The Gab1 protein is a docking site for multiple proteins involved in signaling by the B cell antigen receptor.

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Alternative splicing generates isoforms of the met receptor tyrosine kinase which undergo differential processing

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DNA-mediated transfer of the adenine phosphoribosyltransferase locus into mammalian cells

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Identification of a ten-amino acid proline-rich SH3 binding site

1 reference

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Structural determinants of peptide-binding orientation and of sequence specificity in SH3 domains

1 reference

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Structural basis for the binding of proline-rich peptides to SH3 domains

1 reference

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Critical residues in an SH3 domain from Sem-5 suggest a mechanism for proline-rich peptide recognition

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NMR structure of the N-terminal SH3 domain of GRB2 and its complex with a proline-rich peptide from Sos

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Structure of the N-terminal SH3 domain of GRB2 complexed with a peptide from the guanine nucleotide releasing factor Sos.

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Molecular cloning of SLP-76, a 76-kDa tyrosine phosphoprotein associated with Grb2 in T cells

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The hematopoietic-specific adaptor protein gads functions in T-cell signaling via interactions with the SLP-76 and LAT adaptors

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Grf40, A novel Grb2 family member, is involved in T cell signaling through interaction with SLP-76 and LAT

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Implication of the GRB2-associated phosphoprotein SLP-76 in T cell receptor-mediated interleukin 2 production

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SH3 domains. Minding your p's and q's.

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The SH2 and SH3 domains of mammalian Grb2 couple the EGF receptor to the Ras activator mSos1

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Guanine-nucleotide-releasing factor hSos1 binds to Grb2 and links receptor tyrosine kinases to Ras signalling

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A novel peptide-SH3 interaction.

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Molecular cloning and expression of human grap-2, a novel leukocyte-specific SH2- and SH3-containing adaptor-like protein that binds to gab-1

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Gads is a novel SH2 and SH3 domain-containing adaptor protein that binds to tyrosine-phosphorylated Shc

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Specific interactions outside the proline-rich core of two classes of Src homology 3 ligands

1 reference

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Association of Sos Ras exchange protein with Grb2 is implicated in tyrosine kinase signal transduction and transformation

1 reference

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The src homology domain 2-containing inositol phosphatase SHIP forms a ternary complex with Shc and Grb2 in antigen receptor-stimulated B lymphocytes

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Identifiers

10.1074/JBC.M003597200

1 reference

Europe PubMed Central

9 June 2017

1 reference

Europe PubMed Central

9 June 2017

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