(Q30300790)

20 September 2017

Chemical biology. A small-molecule inhibitor of the aberrant transcription factor CBFβ-SMMHC delays leukemia in mice (English)

1 reference

20 September 2017

1 reference

7

1 reference

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2 June 2020

John H Bushweller

14

1 reference

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2 June 2020

author name string

Anuradha Illendula

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25678665%20AND%20SRC:MED&resulttype=core&format=json

2 June 2020

John A Pulikkan

2

1 reference

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2 June 2020

Hongliang Zong

3

1 reference

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2 June 2020

Jolanta Grembecka

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25678665%20AND%20SRC:MED&resulttype=core&format=json

2 June 2020

Liting Xue

5

1 reference

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2 June 2020

Siddhartha Sen

6

1 reference

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2 June 2020

Adam Boulton

8

1 reference

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2 June 2020

Aravinda Kuntimaddi

9

1 reference

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2 June 2020

Yan Gao

10

1 reference

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2 June 2020

Roger A Rajewski

11

1 reference

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2 June 2020

Monica L Guzman

12

1 reference

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2 June 2020

Lucio H Castilla

13

1 reference

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2 June 2020

language of work or name

English

0 references

publication date

1 February 2015

1 reference

20 September 2017

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25678665%20AND%20SRC:MED&resulttype=core&format=json

2 June 2020

volume

347

1 reference

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2 June 2020

issue

6223

1 reference

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2 June 2020

page(s)

779-784

1 reference

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NrasG12D oncoprotein inhibits apoptosis of preleukemic cells expressing Cbfβ-SMMHC via activation of MEK/ERK axis

2 June 2020

cites work

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4423805

Recurrent gene fusions in prostate cancer: their clinical implications and uses

3 June 2018

1 reference

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Runx1 deletion or dominant inhibition reduces Cebpa transcription via conserved promoter and distal enhancer sites to favor monopoiesis over granulopoiesis

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4423805

Genetic abnormalities and challenges in the treatment of acute myeloid leukemia

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4423805

The art of the chemical probe

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4423805

Trifluoromethyl ethers--synthesis and properties of an unusual substituent

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4423805

Allosteric Inhibition of the Protein-Protein Interaction between the Leukemia-Associated Proteins Runx1 and CBFβ

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4423805

Progress in the treatment of acute myeloid leukemia

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4423805

Synthetic multivalent ligands as probes of signal transduction

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4423805

Core-binding factors in hematopoiesis and immune function

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4423805

Identification of genes that synergize with Cbfb-MYH11 in the pathogenesis of acute myeloid leukemia

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4423805

Altered affinity of CBF beta-SMMHC for Runx1 explains its role in leukemogenesis

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4423805

Function of CBFbeta/Bro proteins

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4423805

Solution structure of core binding factor beta and map of the CBF alpha binding site

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4423805

Oncogenic transcription factors in the human acute leukemias

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4423805

Fusion between transcription factor CBF beta/PEBP2 beta and a myosin heavy chain in acute myeloid leukemia

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4423805

Identification of a region which directs the monocytic activity of the colony-stimulating factor 1 (macrophage colony-stimulating factor) receptor promoter and binds PEBP2/CBF (AML1)

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4423805

The emerging molecular genetics of sarcoma translocations.

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4423805

Studies of FLT3 mutations in paired presentation and relapse samples from patients with acute myeloid leukemia: implications for the role of FLT3 mutations in leukemogenesis, minimal residual disease detection, and possible therapy with FLT3 inhibit

3 June 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAA0314

Cooperating mutations of receptor tyrosine kinases and Ras genes in childhood core-binding factor acute myeloid leukemia and a comparative analysis on paired diagnosis and relapse samples

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAA0314

Molecular evolution of acute myeloid leukaemia in relapse: unstable N-ras and FLT3 genes compared with p53 gene.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAA0314

The CBFbeta subunit is essential for CBFalpha2 (AML1) function in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAA0314

Preferential induction of apoptosis for primary human leukemic stem cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAA0314

The sesquiterpene lactone parthenolide induces apoptosis of human acute myelogenous leukemia stem and progenitor cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAA0314

New trends in the chemistry of α-fluorinated ethers, thioethers, amines and phosphines

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAA0314

The fusion gene Cbfb-MYH11 blocks myeloid differentiation and predisposes mice to acute myelomonocytic leukaemia

21 January 2018

1 reference

12 December 2020

Cbf beta-SMMHC induces distinct abnormal myeloid progenitors able to develop acute myeloid leukemia

1 reference

12 December 2020

Cbfbeta reduces Cbfbeta-SMMHC-associated acute myeloid leukemia in mice

1 reference

12 December 2020

Methylation-independent silencing of the tumor suppressor INK4b (p15) by CBFbeta-SMMHC in acute myelogenous leukemia with inv(16)

1 reference

12 December 2020

Transcriptional repression of the RUNX3/AML2 gene by the t(8;21) and inv(16) fusion proteins in acute myeloid leukemia

1 reference

12 December 2020

AML with CBFB-MYH11 rearrangement demonstrate RAS pathway alterations in 92% of all cases including a high frequency of NF1 deletions

1 reference

12 December 2020

Polyvalent Interactions in Biological Systems: Implications for Design and Use of Multivalent Ligands and Inhibitors

1 reference

12 December 2020

CBF beta-SMMHC, expressed in M4Eo AML, reduced CBF DNA-binding and inhibited the G1 to S cell cycle transition at the restriction point in myeloid and lymphoid cells

1 reference

12 December 2020

Identifiers

DOI

10.1126/SCIENCE.AAA0314

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25678665%20AND%20SRC:MED&resulttype=core&format=json

2 June 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25678665%20AND%20SRC:MED&resulttype=core&format=json

2 June 2020

PubMed publication ID

25678665

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25678665%20AND%20SRC:MED&resulttype=core&format=json