(Q30317935)

14 September 2017

Inhibitors of the NAD(+)-Dependent Protein Desuccinylase and Demalonylase Sirt5 (English)

1 reference

14 September 2017

7

1 reference

14 September 2017

8

1 reference

14 September 2017

9

1 reference

14 September 2017

Benjamin Maurer

1

1 reference

14 September 2017

Tobias Rumpf

2

1 reference

14 September 2017

Michael Scharfe

3

1 reference

14 September 2017

Diana A Stolfa

4

1 reference

14 September 2017

Martin L Schmitt

5

1 reference

14 September 2017

Wenjuan He

6

1 reference

14 September 2017

language of work or name

1 reference

6 October 2012

1 reference

ACS Medicinal Chemistry Letters

14 September 2017

1 reference

14 September 2017

3

1 reference

14 September 2017

12

1 reference

14 September 2017

1050-1053

1 reference

Thiosuccinyl peptides as Sirt5-specific inhibitors

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4025838

Old enzymes, new tricks: sirtuins are NAD(+)-dependent de-acylases

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4025838

Sirt5 is a NAD-dependent protein lysine demalonylase and desuccinylase

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4025838

Plasmodium falciparum Sir2A Preferentially Hydrolyzes Medium and Long Chain Fatty Acyl Lysine

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4025838

Repairing split ends: SIRT6, mono-ADP ribosylation and DNA repair.

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4025838

The first identification of lysine malonylation substrates and its regulatory enzyme

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4025838

Inhibitors to understand molecular mechanisms of NAD(+)-dependent deacetylases (sirtuins).

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4025838

Structural Insights into Intermediate Steps in the Sir2 Deacetylation Reaction

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4025838

Structure-activity studies on splitomicin derivatives as sirtuin inhibitors and computational prediction of binding mode

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4025838

Structural basis of inhibition of the human NAD+-dependent deacetylase SIRT5 by suramin

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4025838

Adenosine mimetics as inhibitors of NAD+-dependent histone deacetylases, from kinase to sirtuin inhibition

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4025838

SIRT4 inhibits glutamate dehydrogenase and opposes the effects of calorie restriction in pancreatic beta cells

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4025838

Antitumor activity of a small-molecule inhibitor of human silent information regulator 2 enzymes

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4025838

In vitro assays for the determination of histone deacetylase activity

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4025838

Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespan

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4025838

Identification of a class of small molecule inhibitors of the sirtuin family of NAD-dependent deacetylases by phenotypic screening

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4025838

An enzymatic activity in the yeast Sir2 protein that is essential for gene silencing

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4025838

Characterization of five human cDNAs with homology to the yeast SIR2 gene: Sir2-like proteins (sirtuins) metabolize NAD and may have protein ADP-ribosyltransferase activity

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4025838

Mechanism-based inhibition of Sir2 deacetylases by thioacetyl-lysine peptide

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4025838

Discovery of indoles as potent and selective inhibitors of the deacetylase SIRT1.

26 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4025838

Subtype selective substrates for histone deacetylases

26 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4025838

Substrates for efficient fluorometric screening employing the NAD-dependent sirtuin 5 lysine deacylase (KDAC) enzyme

26 November 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/24900427

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Nepsilon-thioacetyl-lysine: a multi-facet functional probe for enzymatic protein lysine Nepsilon-deacetylation

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/24900427

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1021/ML3002709

1 reference

14 September 2017

1 reference

14 September 2017

PubMed publication ID

24900427

1 reference