(Q30350979)

20 June 2017

title

Recent advances in our understanding of protein conformational stability from a pharmaceutical perspective. (English)

1 reference

20 June 2017

Middaugh CR

1

1 reference

20 June 2017

Edwards KL

series ordinal

2

1 reference

20 June 2017

language of work or name

English

0 references

publication date

1 September 1998

1 reference

Expert Opinion on Investigational Drugs

20 June 2017

published in

1 reference

20 June 2017

volume

7

1 reference

20 June 2017

issue

9

1 reference

20 June 2017

page(s)

1493-1500

1 reference

Analysis of the effect of local interactions on protein stability.

20 June 2017

cites work

1 reference

https://api.crossref.org/works/10.1517%2F13543784.7.9.1493

Engineering enzymes for stability

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.7.9.1493

The denaturation and degradation of stable enzymes at high temperatures

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.7.9.1493

Hydrophobic core repacking and aromatic-aromatic interaction in the thermostable mutant of T4 lysozyme Ser 117-->Phe

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.7.9.1493

The crystal structure of a mutant protein with altered but improved hydrophobic core packing

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.7.9.1493

Design and structural analysis of an engineered thermostable chicken lysozyme

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.7.9.1493

Thermal stability determinants of chicken egg-white lysozyme core mutants: hydrophobicity, packing volume, and conserved buried water molecules

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.7.9.1493

Enhancement of protein stability by the combination of point mutations in T4 lysozyme is additive

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.7.9.1493

Potential use of additivity of mutational effects in simplifying protein engineering

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.7.9.1493

Contribution of individual side-chains to the stability of BPTI examined by alanine-scanning mutagenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.7.9.1493

Contribution of the hydrophobic effect to the stability of human lysozyme: calorimetric studies and X-ray structural analyses of the nine valine to alanine mutants

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.7.9.1493

Stabilization of human triosephosphate isomerase by improvement of the stability of individual alpha-helices in dimeric as well as monomeric forms of the protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.7.9.1493

Protein structural plasticity exemplified by insertion and deletion mutants in T4 lysozyme

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.7.9.1493

Evidence on close packing and cavities in proteins.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.7.9.1493

Stabilization of Escherichia coli ribonuclease HI by cavity-filling mutations within a hydrophobic core

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.7.9.1493

Structural and energetic responses to cavity-creating mutations in hydrophobic cores: observation of a buried water molecule and the hydrophilic nature of such hydrophobic cavities

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.7.9.1493

Mobile unnatural amino acid side chains in the core of staphylococcal nuclease

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.7.9.1493

Controlling topology and native-like behavior of de novo-designed peptides: design and characterization of antiparallel four-stranded coiled coils

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.7.9.1493

Prediction of the stability of protein mutants based on structural environment-dependent amino acid substitution and propensity tables

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.7.9.1493

Side-chain entropy and packing in proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.7.9.1493

Barriers to protein folding: formation of buried polar interactions is a slow step in acquisition of structure.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.7.9.1493

Core-packing constraints, hydrophobicity and protein design

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.7.9.1493

Importance of two buried salt bridges in the stability and folding pathway of barnase.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.7.9.1493

Contributions of the ionizable amino acids to the stability of staphylococcal nuclease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.7.9.1493

Engineering thermostability: lessons from thermophilic proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.7.9.1493

Kinetic role of electrostatic interactions in the unfolding of hyperthermophilic and mesophilic rubredoxins

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.7.9.1493

The optimization of protein-solvent interactions: thermostability and the role of hydrophobic and electrostatic interactions

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.7.9.1493

Structure of a hyperthermophilic tungstopterin enzyme, aldehyde ferredoxin oxidoreductase

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.7.9.1493

The complete genome of the hyperthermophilic bacterium Aquifex aeolicus

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.7.9.1493

An unusual route to thermostability disclosed by the comparison of Thermus thermophilus and Escherichia coli inorganic pyrophosphatases

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.7.9.1493

Crystal structures of CheY from Thermotoga maritima do not support conventional explanations for the structural basis of enhanced thermostability

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.7.9.1493

Structural features that stabilize halophilic malate dehydrogenase from an archaebacterium

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.7.9.1493

A procedure for the prediction of temperature-sensitive mutants of a globular protein based solely on the amino acid sequence

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.7.9.1493

Serial increase in the thermal stability of 3-isopropylmalate dehydrogenase from Bacillus subtilis by experimental evolution

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.7.9.1493

Amino-acid substitutions in a surface turn modulate protein stability

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.7.9.1493

Perturbations of the denatured state ensemble: modeling their effects on protein stability and folding kinetics

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.7.9.1493

Extreme stabilization of a thermolysin-like protease by an engineered disulfide bond

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.7.9.1493

Incorporation of tryptophan analogues into staphylococcal nuclease: stability toward thermal and guanidine-HCl induced unfolding

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.7.9.1493

A relationship between protein stability and protein function

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.7.9.1493

Minimizing a binding domain from protein A.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.7.9.1493

Structural Factors Contributing to the Hydrophobic Effect: The Partly Exposed Hydrophobic Minicore in Chymotrypsin Inhibitor 2

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.7.9.1493

10.1517/13543784.7.9.1493

21 January 2018

Identifiers

DOI

1 reference

20 June 2017

1 reference