(Q30360830)

20 June 2017

title

Significance of local mobility in aggregation of beta-galactosidase lyophilized with trehalose, sucrose or stachyose. (English)

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20 June 2017

main subject

alpha,alpha-trehalose

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author name string

Sumie Yoshioka

1

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20 June 2017

Tamaki Miyazaki

2

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20 June 2017

Yukio Aso

3

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20 June 2017

Tohru Kawanishi

4

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20 June 2017

publication date

3 April 2007

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20 June 2017

published in

Pharmaceutical Research

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20 June 2017

volume

24

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20 June 2017

issue

9

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20 June 2017

page(s)

1660-1667

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Effect of glass transition temperature on the stability of lyophilized formulations containing a chimeric therapeutic monoclonal antibody

20 June 2017

cites work

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12 December 2020

Effect of polymer excipients on the enzyme activity of lyophilized bilirubin oxidase and beta-galactosidase formulations

1 reference

12 December 2020

Separation of freezing- and drying-induced denaturation of lyophilized proteins using stress-specific stabilization. II. Structural studies using infrared spectroscopy.

1 reference

12 December 2020

Mechanism of protein stabilization by sugars during freeze-drying and storage: native structure preservation, specific interaction, and/or immobilization in a glassy matrix?

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12 December 2020

Effect of sorbitol and residual moisture on the stability of lyophilized antibodies: Implications for the mechanism of protein stabilization in the solid state.

1 reference

12 December 2020

Usefulness of the Kohlrausch-Williams-Watts stretched exponential function to describe protein aggregation in lyophilized formulations and the temperature dependence near the glass transition temperature.

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12 December 2020

Inactivation and aggregation of beta-galactosidase in lyophilized formulation described by Kohlrausch-Williams-Watts stretched exponential function

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12 December 2020

Molecular mobility of protein in lyophilized formulations linked to the molecular mobility of polymer excipients, as determined by high resolution 13C solid-state NMR.

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12 December 2020

Determination of molecular mobility of lyophilized bovine serum albumin and gamma-globulin by solid-state 1H NMR and relation to aggregation-susceptibility

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12 December 2020

Softening temperature of lyophilized bovine serum albumin and gamma-globulin as measured by spin-spin relaxation time of protein protons

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12 December 2020

Correlations between molecular mobility and chemical stability during storage of amorphous pharmaceuticals

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12 December 2020

The effects of formulation variables on the stability of freeze-dried human growth hormone

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12 December 2020

Dependence of the molecular mobility and protein stability of freeze-dried gamma-globulin formulations on the molecular weight of dextran

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12 December 2020

The effect of the reconstitution medium on aggregation of lyophilized recombinant interleukin-2 and ribonuclease A.

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12 December 2020

The effect of excipients on the molecular mobility of lyophilized formulations, as measured by glass transition temperature and NMR relaxation-based critical mobility temperature

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12 December 2020

Optimization of lyophilization conditions for recombinant human interleukin-2 by dried-state conformational analysis using Fourier-transform infrared spectroscopy

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12 December 2020

10.1007/S11095-007-9296-2

Identifiers

DOI

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20 June 2017

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