(Q30414092)

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Blocking metabotropic glutamate receptor subtype 7 (mGlu7) via the Venus flytrap domain (VFTD) inhibits amygdala plasticity, stress, and anxiety-related behavior

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Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24596089%20AND%20SRC:MED&resulttype=core&format=json

9 March 2020

Blocking metabotropic glutamate receptor subtype 7 (mGlu7) via the Venus flytrap domain (VFTD) inhibits amygdala plasticity, stress, and anxiety-related behavior (English)

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24596089%20AND%20SRC:MED&resulttype=core&format=json

9 March 2020

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9 March 2020

13

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9 March 2020

Christine E Gee

1

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9 March 2020

Klemens Kaupmann

5

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9 March 2020

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Daniel Peterlik

2

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9 March 2020

Christoph Neuhäuser

3

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9 March 2020

Rochdi Bouhelal

4

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9 March 2020

Grit Laue

6

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9 March 2020

Nicole Uschold-Schmidt

7

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9 March 2020

Dominik Feuerbach

8

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9 March 2020

Kaspar Zimmermann

9

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9 March 2020

Silvio Ofner

10

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9 March 2020

Herman van der Putten

12

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9 March 2020

Ivo Vranesic

14

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9 March 2020

Ralf Glatthar

15

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9 March 2020

Peter J Flor

16

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9 March 2020

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4 March 2014

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9 March 2020

Journal of Biological Chemistry

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9 March 2020

289

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9 March 2020

16

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9 March 2020

10975-10987

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9 March 2020

Minireview: Nutrient sensing by G protein-coupled receptors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4036238

20 June 2018

ADX71743, a potent and selective negative allosteric modulator of metabotropic glutamate receptor 7: in vitro and in vivo characterization

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4036238

20 June 2018

Critical analysis of the successes and failures of homology models of G protein-coupled receptors.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4036238

20 June 2018

Neural substrates for the distinct effects of presynaptic group III metabotropic glutamate receptors on extinction of contextual fear conditioning in mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4036238

20 June 2018

Orthosteric versus allosteric GPCR activation: the great challenge of group-III mGluRs

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4036238

20 June 2018

Gastrin-releasing peptide signaling plays a limited and subtle role in amygdala physiology and aversive memory

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4036238

20 June 2018

Metabotropic glutamate receptors: from the workbench to the bedside

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4036238

20 June 2018

Receptor activity modifying proteins and their potential as drug targets

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4036238

20 June 2018

The metabotropic glutamate receptor mGlu7 activates phospholipase C, translocates munc-13-1 protein, and potentiates glutamate release at cerebrocortical nerve terminals

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4036238

20 June 2018

Metabotropic glutamate receptor 7: at the interface of cognition and emotion

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4036238

20 June 2018

Effects of a novel metabotropic glutamate receptor 7 negative allosteric modulator, 6-(4-methoxyphenyl)-5-methyl-3-pyridin-4-ylisoxazonolo[4,5-c]pyridin-4(5H)-one (MMPIP), on the central nervous system in rodents.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4036238

20 June 2018

Context-dependent pharmacology exhibited by negative allosteric modulators of metabotropic glutamate receptor 7

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4036238

20 June 2018

Group III mGluR7 and mGluR8 in the amygdala differentially modulate nocifensive and affective pain behaviors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4036238

20 June 2018

Galpha-subunits differentially alter the conformation and agonist affinity of kappa-opioid receptors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4036238

20 June 2018

Target-cell-dependent plasticity within the mossy fibre-CA3 circuit reveals compartmentalized regulation of presynaptic function at divergent release sites

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4036238

20 June 2018

Activation of the mGlu7 receptor elicits antidepressant-like effects in mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4036238

20 June 2018

Expression, purification, crystallization and preliminary X-ray analysis of the ligand-binding domain of metabotropic glutamate receptor 7

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4036238

20 June 2018

In vitro pharmacological characterization of novel isoxazolopyridone derivatives as allosteric metabotropic glutamate receptor 7 antagonists.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4036238

20 June 2018

Structures of the extracellular regions of the group II/III metabotropic glutamate receptors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4036238

20 June 2018

mGluR7 undergoes rapid internalization in response to activation by the allosteric agonist AMN082.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4036238

20 June 2018

Concomitant deficits in working memory and fear extinction are functionally dissociated from reduced anxiety in metabotropic glutamate receptor 7-deficient mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4036238

20 June 2018

A selective metabotropic glutamate receptor 7 agonist: activation of receptor signaling via an allosteric site modulates stress parameters in vivo

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4036238

20 June 2018

Metabotropic glutamate receptor subtype 7 ablation causes dysregulation of the HPA axis and increases hippocampal BDNF protein levels: implications for stress-related psychiatric disorders

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4036238

20 June 2018

International Union of Pharmacology. XLVI. G protein-coupled receptor list.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4036238

20 June 2018

(-)-PHCCC, a positive allosteric modulator of mGluR4: characterization, mechanism of action, and neuroprotection.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4036238

20 June 2018

Antidepressant and anxiolytic-like effects in mice lacking the group III metabotropic glutamate receptor mGluR7

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4036238

20 June 2018

Evolution, structure, and activation mechanism of family 3/C G-protein-coupled receptors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4036238

20 June 2018

Closure of the Venus flytrap module of mGlu8 receptor and the activation process: Insights from mutations converting antagonists into agonists

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4036238

20 June 2018

Assessing antidepressant activity in rodents: recent developments and future needs

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4036238

20 June 2018

Structural views of the ligand-binding cores of a metabotropic glutamate receptor complexed with an antagonist and both glutamate and Gd3+.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4036238

20 June 2018

Increased seizure susceptibility in mice lacking metabotropic glutamate receptor 7

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4036238

20 June 2018

Unveiling the functions of presynaptic metabotropic glutamate receptors in the central nervous system

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4036238

20 June 2018

Structural basis of glutamate recognition by a dimeric metabotropic glutamate receptor

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4036238

20 June 2018

Animal models of depression: utility for transgenic research

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4036238

20 June 2018

2-Methyl-6-(phenylethynyl)-pyridine (MPEP), a potent, selective and systemically active mGlu5 receptor antagonist

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4036238

20 June 2018

(R,S)-4-phosphonophenylglycine, a potent and selective group III metabotropic glutamate receptor agonist, is anticonvulsive and neuroprotective in vivo

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4036238

20 June 2018

Molecular tinkering of G protein-coupled receptors: an evolutionary success

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4036238

20 June 2018

CPCCOEt, a noncompetitive metabotropic glutamate receptor 1 antagonist, inhibits receptor signaling without affecting glutamate binding

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4036238

20 June 2018

Metabotropic glutamate receptor subtype 7 ablation causes deficit in fear response and conditioned taste aversion

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4036238

20 June 2018

Cloning and stable expression of the mGluR1b subtype of human metabotropic receptors and pharmacological comparison with the mGluR5a subtype

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4036238

20 June 2018

A novel splice variant of a metabotropic glutamate receptor, human mGluR7b

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4036238

20 June 2018

Molecular cloning, functional expression and pharmacological characterization of the human metabotropic glutamate receptor type 4

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4036238

20 June 2018

Selective activation of metabotropic G-protein-coupled glutamate 7 receptor elicits anxiolytic-like effects in mice by modulating GABAergic neurotransmission.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M113.542654

21 January 2018

Differential roles of mGlu(7) and mGlu(8) in amygdala-dependent behavior and physiology.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M113.542654

21 January 2018

Adult siRNA-induced knockdown of mGlu7 receptors reduces anxiety in the mouse.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M113.542654

21 January 2018

mGluR7 facilitates extinction of aversive memories and controls amygdala plasticity.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M113.542654

21 January 2018

The metabotropic glutamate receptor 7 allosteric modulator AMN082: a monoaminergic agent in disguise?

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M113.542654

21 January 2018

Isoxazolopyridone derivatives as allosteric metabotropic glutamate receptor 7 antagonists.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M113.542654

21 January 2018

The agonist selectivity of a class III metabotropic glutamate receptor, human mGluR4a, is determined by the N-terminal extracellular domain

2 references

https://api.crossref.org/works/10.1074%2FJBC.M113.542654

21 January 2018

https://pubmed.ncbi.nlm.nih.gov/24596089

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Presynaptic induction of heterosynaptic associative plasticity in the mammalian brain

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M113.542654

21 January 2018

Relationship between exposure and nonspecific binding of thirty-three central nervous system drugs in mice.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M113.542654

21 January 2018

Behavioural consequences of two chronic psychosocial stress paradigms: anxiety without depression.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M113.542654

21 January 2018

Adrenal insufficiency and colonic inflammation after a novel chronic psycho-social stress paradigm in mice: implications and mechanisms.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M113.542654

21 January 2018

Pharmacological interference with metabotropic glutamate receptor subtype 7 but not subtype 5 differentially affects within- and between-session extinction of Pavlovian conditioned fear.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M113.542654

21 January 2018

Induction mechanisms for L-LTP at thalamic input synapses to the lateral amygdala: requirement of mGluR5 activation

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M113.542654

21 January 2018

mGluR7 is a metaplastic switch controlling bidirectional plasticity of feedforward inhibition.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M113.542654

21 January 2018

Compartmentalized Ca(2+) channel regulation at divergent mossy-fiber release sites underlies target cell-dependent plasticity.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M113.542654

21 January 2018

Molecular basis for the differential agonist affinities of group III metabotropic glutamate receptors

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M113.542654

21 January 2018

Deficits in acquisition and extinction of conditioned responses in mGluR7 knockout mice

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M113.542654

21 January 2018

The group I metabotropic glutamate receptor mGluR5 is required for fear memory formation and long-term potentiation in the lateral amygdala.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4036238

26 November 2018

Conditioned and unconditional components of post-shock freezing.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4036238

26 November 2018

Functional coupling of a human retinal metabotropic glutamate receptor (hmGluR6) to bovine rod transducin and rat Go in an in vitro reconstitution system

1 reference

https://pubmed.ncbi.nlm.nih.gov/24596089

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Exploration of structure-based drug design opportunities for mGluRs

1 reference

https://pubmed.ncbi.nlm.nih.gov/24596089

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1074/JBC.M113.542654

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24596089%20AND%20SRC:MED&resulttype=core&format=json

9 March 2020

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24596089%20AND%20SRC:MED&resulttype=core&format=json

9 March 2020

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24596089%20AND%20SRC:MED&resulttype=core&format=json

9 March 2020

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