(Q30420796)

21 June 2017

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22 October 2022

Development of chemical inhibitors of the SARS coronavirus: viral helicase as a potential target (English)

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21 June 2017

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Young-Sam Keum

1

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21 June 2017

Yong-Joo Jeong

series ordinal

2

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21 June 2017

language of work or name

English

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publication date

23 August 2012

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21 June 2017

15 November 2012

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22 October 2022

Biochemical Pharmacology

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21 June 2017

22 October 2022

84

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21 June 2017

issue

10

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21 June 2017

page(s)

1351-1358

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Polynucleotide modulation of the protease, nucleoside triphosphatase, and helicase activities of a hepatitis C virus NS3-NS4A complex isolated from transfected COS cells

21 June 2017

cites work

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12 December 2020

E. coli Rep oligomers are required to initiate DNA unwinding in vitro

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12 December 2020

Active disruption of an RNA-protein interaction by a DExH/D RNA helicase

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12 December 2020

The severe acute respiratory syndrome (SARS) coronavirus NTPase/helicase belongs to a distinct class of 5' to 3' viral helicases.

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12 December 2020

A steady-state and pre-steady-state kinetic analysis of the NTPase activity associated with the hepatitis C virus NS3 helicase domain

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12 December 2020

A Dimer of Escherichia coli UvrD is the active form of the helicase in vitro

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12 December 2020

Non-hexameric DNA helicases and translocases: mechanisms and regulation

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12 December 2020

Kinetic pathway of dTTP hydrolysis by hexameric T7 helicase-primase in the absence of DNA.

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12 December 2020

Uncoupling DNA translocation and helicase activity in PcrA: direct evidence for an active mechanism.

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12 December 2020

Multiple enzymatic activities associated with severe acute respiratory syndrome coronavirus helicase

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12 December 2020

The adamantane-derived bananins are potent inhibitors of the helicase activities and replication of SARS coronavirus.

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12 December 2020

Mechanism of ATP-dependent translocation of E.coli UvrD monomers along single-stranded DNA.

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12 December 2020

Strategies adopted and lessons learnt during the severe acute respiratory syndrome crisis in Singapore

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12 December 2020

Biochemical and kinetic characterization of the RNA helicase activity of eukaryotic initiation factor 4A

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12 December 2020

UvrD helicase, unlike Rep helicase, dismantles RecA nucleoprotein filaments in Escherichia coli.

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12 December 2020

Unique and conserved features of genome and proteome of SARS-coronavirus, an early split-off from the coronavirus group 2 lineage

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12 December 2020

Tertiary structure prediction of SARS coronavirus helicase

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12 December 2020

T7 DNA helicase: a molecular motor that processively and unidirectionally translocates along single-stranded DNA.

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12 December 2020

Interactions of bacteriophage T7 DNA primase/helicase protein with single-stranded and double-stranded DNAs

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12 December 2020

Severe acute respiratory syndrome (SARS)--paradigm of an emerging viral infection.

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12 December 2020

Increasing the Length of the Single-Stranded Overhang Enhances Unwinding of Duplex DNA by Bacteriophage T4 Dda Helicase†

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12 December 2020

A new RNA helicase isolated from HeLa cells that catalytically translocates in the 3' to 5' direction

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12 December 2020

Mechanism of dnaB protein action. II. ATP hydrolysis by dnaB protein dependent on single- or double-stranded DNA

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12 December 2020

SARS: systematic review of treatment effects

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12 December 2020

SARS coronavirus pathogenesis: host innate immune responses and viral antagonism of interferon

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12 December 2020

Evidence for a functional dimeric form of the PcrA helicase in DNA unwinding

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12 December 2020

Characterization of the reovirus lambda1 protein RNA 5'-triphosphatase activity

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12 December 2020

Inhibition of SARS coronavirus helicase by bismuth complexes.

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12 December 2020

Kinetic measurement of the step size of DNA unwinding by Escherichia coli UvrD helicase

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12 December 2020

Severe acute respiratory syndrome (SARS): over 100 days into the outbreak

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12 December 2020

Crystal structures of complexes of PcrA DNA helicase with a DNA substrate indicate an inchworm mechanism

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12 December 2020

DNA helicases in inherited human disorders

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12 December 2020

The Bloom's syndrome gene product is homologous to RecQ helicases

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12 December 2020

Exacerbated innate host response to SARS-CoV in aged non-human primates

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12 December 2020

Pre-steady-state DNA unwinding by bacteriophage T4 Dda helicase reveals a monomeric molecular motor

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12 December 2020

Investigation of the pharmacophore space of Severe Acute Respiratory Syndrome coronavirus (SARS-CoV) NTPase/helicase by dihydroxychromone derivatives.

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12 December 2020

Demonstration of unidirectional single-stranded DNA translocation by PcrA helicase: measurement of step size and translocation speed

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12 December 2020

Bismuth complexes inhibit the SARS coronavirus

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12 December 2020

Mechanisms of helicase-catalyzed DNA unwinding

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12 December 2020

The DExH protein NPH-II is a processive and directional motor for unwinding RNA

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12 December 2020

The hepatitis C viral NS3 protein is a processive DNA helicase with cofactor enhanced RNA unwinding

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12 December 2020

The development of the alpha-particle emitting radionuclides 212Bi and 213Bi, and their decay chain related radionuclides, for therapeutic applications

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12 December 2020

Isolation of inhibitory RNA aptamers against severe acute respiratory syndrome (SARS) coronavirus NTPase/Helicase.

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12 December 2020

Structure at 2.8 A resolution of F1-ATPase from bovine heart mitochondria

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12 December 2020

Bacillus stearothermophilus PcrA monomer is a single-stranded DNA translocase but not a processive helicase in vitro.

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12 December 2020

Cooperative translocation enhances the unwinding of duplex DNA by SARS coronavirus helicase nsP13.

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12 December 2020

Mechanisms and enzymes involved in SARS coronavirus genome expression

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12 December 2020

DNA synthesis provides the driving force to accelerate DNA unwinding by a helicase

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12 December 2020

Virus-encoded RNA helicases

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12 December 2020

An oligomeric form of E. coli UvrD is required for optimal helicase activity

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12 December 2020

The Escherichia coli RecQ helicase functions as a monomer

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12 December 2020

Structure and function of hexameric helicases.

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12 December 2020

The DNA-unwinding mechanism of the ring helicase of bacteriophage T7.

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12 December 2020

Identification of myricetin and scutellarein as novel chemical inhibitors of the SARS coronavirus helicase, nsP13.

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12 December 2020

Chromatin remodelling: the industrial revolution of DNA around histones

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12 December 2020

The functional interaction of the hepatitis C virus helicase molecules is responsible for unwinding processivity

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12 December 2020

The helicase-like domain of plant potexvirus replicase participates in formation of RNA 5' cap structure by exhibiting RNA 5'-triphosphatase activity

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12 December 2020

Large scale purification and biochemical characterization of T7 primase/helicase proteins. Evidence for homodimer and heterodimer formation

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12 December 2020

Crystal structure of T7 gene 4 ring helicase indicates a mechanism for sequential hydrolysis of nucleotides

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12 December 2020

Biochemical analysis of mutant T7 primase/helicase proteins defective in DNA binding, nucleotide hydrolysis, and the coupling of hydrolysis with DNA unwinding

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12 December 2020

Characterization of a novel coronavirus associated with severe acute respiratory syndrome

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12 December 2020

Characterization of the nucleoside triphosphate phosphohydrolase and helicase activities of the reovirus lambda1 protein

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12 December 2020

Flavonoids: antioxidants or signalling molecules?

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12 December 2020

Positional cloning of the Werner's syndrome gene

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12 December 2020

Enzymic Unwinding of DNA. 1. Purification and Characterization of a DNA-Dependent ATPase from Escherichia coli

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12 December 2020

Mechanisms of helicases

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12 December 2020

Mechanism of nucleic acid unwinding by SARS-CoV helicase.

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12 December 2020

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12 December 2020

The dTTPase mechanism of T7 DNA helicase resembles the binding change mechanism of the F1-ATPase

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12 December 2020

Structure and mechanism of helicases and nucleic acid translocases

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12 December 2020

The severe acute respiratory syndrome

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12 December 2020

DNA binding mediates conformational changes and metal ion coordination in the active site of PcrA helicase

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12 December 2020

Aryl diketoacids (ADK) selectively inhibit duplex DNA-unwinding activity of SARS coronavirus NTPase/helicase.

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12 December 2020

Development of antiviral therapy for severe acute respiratory syndrome.

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12 December 2020

Three dimensional model of severe acute respiratory syndrome coronavirus helicase ATPase catalytic domain and molecular design of severe acute respiratory syndrome coronavirus helicase inhibitors.

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12 December 2020

Plasma inflammatory cytokines and chemokines in severe acute respiratory syndrome.

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12 December 2020

The Genome sequence of the SARS-associated coronavirus

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12 December 2020

Functional properties of the predicted helicase of porcine reproductive and respiratory syndrome virus

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12 December 2020

10.1016/J.BCP.2012.08.012

Identifiers

DOI

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21 June 2017

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