(Q30423526)

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The gating mechanism of the bacterial mechanosensitive channel MscL revealed by molecular dynamics simulations: from tension sensing to channel opening

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scholarly article

1 reference

Europe PubMed Central

PMC publication ID

9 October 2017

The gating mechanism of the bacterial mechanosensitive channel MscL revealed by molecular dynamics simulations: from tension sensing to channel opening (English)

1 reference

Europe PubMed Central

PMC publication ID

9 October 2017

molecular dynamics simulation

0 references

author name string

Yasuyuki Sawada

1

1 reference

Europe PubMed Central

PMC publication ID

9 October 2017

Masaki Murase

2

1 reference

Europe PubMed Central

PMC publication ID

9 October 2017

Masahiro Sokabe

3

1 reference

Europe PubMed Central

PMC publication ID

9 October 2017

publication date

1 July 2012

1 reference

Europe PubMed Central

PMC publication ID

9 October 2017

1 reference

Europe PubMed Central

PMC publication ID

9 October 2017

6

1 reference

Europe PubMed Central

PMC publication ID

9 October 2017

4

1 reference

Europe PubMed Central

PMC publication ID

9 October 2017

317-331

1 reference

Europe PubMed Central

PMC publication ID

9 October 2017

describes a project that uses

molecular dynamics simulation

1 reference

based on heuristic

inferred from title

All-atom empirical potential for molecular modeling and dynamics studies of proteins

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3508910

20 June 2018

Membrane tension, lipid adaptation, conformational changes, and energetics in MscL gating

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3508910

20 June 2018

Release of content through mechano-sensitive gates in pressurized liposomes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3508910

20 June 2018

Gating-associated conformational changes in the mechanosensitive channel MscL.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3508910

20 June 2018

Gating of the mechanosensitive channel protein MscL: the interplay of membrane and protein

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3508910

20 June 2018

Mechanosensitive membrane channels in action

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3508910

20 June 2018

New insights of membrane environment effects on MscL channel mechanics from theoretical approaches.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3508910

20 June 2018

Dual-color fluorescence-burst analysis to probe protein efflux through the mechanosensitive channel MscL.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3508910

20 June 2018

Disulfide trapping the mechanosensitive channel MscL into a gating-transition state.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3508910

20 June 2018

Molecular dynamics study of MscL interactions with a curved lipid bilayer.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3508910

20 June 2018

Assessment of potential stimuli for mechano-dependent gating of MscL: effects of pressure, tension, and lipid headgroups

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3508910

20 June 2018

Gain-of-function mutations reveal expanded intermediate states and a sequential action of two gates in MscL

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3508910

20 June 2018

Lipid bilayer pressure profiles and mechanosensitive channel gating

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3508910

20 June 2018

Loss-of-function mutations at the rim of the funnel of mechanosensitive channel MscL

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3508910

20 June 2018

Gating of MscL Studied by Steered Molecular Dynamics

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3508910

20 June 2018

Generation and evaluation of a large mutational library from the Escherichia coli mechanosensitive channel of large conductance, MscL: implications for channel gating and evolutionary design

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3508910

20 June 2018

Open-state disulfide crosslinking between Mycobacterium tuberculosis mechanosensitive channel subunits

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3508910

20 June 2018

Simulation of MscL gating in a bilayer under stress.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3508910

20 June 2018

Open channel structure of MscL and the gating mechanism of mechanosensitive channels.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3508910

20 June 2018

A large iris-like expansion of a mechanosensitive channel protein induced by membrane tension

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3508910

20 June 2018

Conformational pathways in the gating of Escherichia coli mechanosensitive channel

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3508910

20 June 2018

Gating the bacterial mechanosensitive channel MscL invivo.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3508910

20 June 2018

Molecular dynamics simulations of wild-type and mutant forms of the Mycobacterium tuberculosis MscL channel

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3508910

20 June 2018

Structural models of the MscL gating mechanism

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3508910

20 June 2018

Chemically charging the pore constriction opens the mechanosensitive channel MscL.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3508910

20 June 2018

Structural determinants of MscL gating studied by molecular dynamics simulations

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3508910

20 June 2018

Molecular basis of mechanotransduction in living cells.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3508910

20 June 2018

The gating mechanism of the large mechanosensitive channel MscL

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3508910

20 June 2018

Mesoscopic undulations and thickness fluctuations in lipid bilayers from molecular dynamics simulations

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3508910

20 June 2018

Correlating a protein structure with function of a bacterial mechanosensitive channel

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3508910

20 June 2018

Contributions of the different extramembranous domains of the mechanosensitive ion channel MscL to its response to membrane tension.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3508910

20 June 2018

Is the protein/lipid hydrophobic matching principle relevant to membrane organization and functions?

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3508910

20 June 2018

Hydrophilicity of a single residue within MscL correlates with increased channel mechanosensitivity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3508910

20 June 2018

Protection of Escherichia coli cells against extreme turgor by activation of MscS and MscL mechanosensitive channels: identification of genes required for MscS activity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3508910

20 June 2018

Energetic and spatial parameters for gating of the bacterial large conductance mechanosensitive channel, MscL

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3508910

20 June 2018

Structure of the MscL homolog from Mycobacterium tuberculosis: a gated mechanosensitive ion channel

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3508910

20 June 2018

One face of a transmembrane helix is crucial in mechanosensitive channel gating

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3508910

20 June 2018

Estimation of the pore size of the large-conductance mechanosensitive ion channel of Escherichia coli.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3508910

20 June 2018

HOLE: a program for the analysis of the pore dimensions of ion channel structural models

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3508910

20 June 2018

The lateral pressure profile in membranes: a physical mechanism of general anesthesia

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3508910

20 June 2018

Single residue substitutions that change the gating properties of a mechanosensitive channel in Escherichia coli

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3508910

20 June 2018

VMD: visual molecular dynamics

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3508910

20 June 2018

Models of lipid-protein interactions in membranes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3508910

20 June 2018

Purification and functional reconstitution of the recombinant large mechanosensitive ion channel (MscL) of Escherichia coli.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3508910

20 June 2018

A large-conductance mechanosensitive channel in E. coli encoded by mscL alone

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3508910

20 June 2018

Mattress model of lipid-protein interactions in membranes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3508910

20 June 2018

Quantitative video microscopy of patch clamped membranes stress, strain, capacitance, and stretch channel activation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3508910

20 June 2018

Particle mesh Ewald: An N⋅log(N) method for Ewald sums in large systems

1 reference

https://api.crossref.org/works/10.4161%2FCHAN.21895

21 January 2018

Lipid properties and the orientation of aromatic residues in OmpF, influenza M2, and alamethicin systems: molecular dynamics simulations

1 reference

https://api.crossref.org/works/10.4161%2FCHAN.21895

21 January 2018

Exploring the role of C-H....pi interactions on the structural stability of single chain "all-alpha" proteins.

1 reference

https://api.crossref.org/works/10.4161%2FCHAN.21895

21 January 2018

Hydration properties of mechanosensitive channel pores define the energetics of gating

1 reference

https://api.crossref.org/works/10.4161%2FCHAN.21895

21 January 2018

Identifiers

10.4161/CHAN.21895

1 reference

Europe PubMed Central

PMC publication ID

9 October 2017

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

9 October 2017

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

9 October 2017

ResearchGate publication ID

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