(Q30426130)

15 August 2017

A novel B-domain O-glycoPEGylated FVIII (N8-GP) demonstrates full efficacy and prolonged effect in hemophilic mice models (English)

1 reference

15 August 2017

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Henning R Stennicke

1

1 reference

15 August 2017

Marianne Kjalke

2

1 reference

15 August 2017

Ditte M Karpf

3

1 reference

15 August 2017

Kristoffer W Balling

4

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15 August 2017

Peter B Johansen

5

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15 August 2017

Torben Elm

6

1 reference

15 August 2017

Kristine Øvlisen

7

1 reference

15 August 2017

Flemming Möller

8

1 reference

15 August 2017

Heidi L Holmberg

9

1 reference

15 August 2017

Charlotte N Gudme

10

1 reference

15 August 2017

Egon Persson

11

1 reference

15 August 2017

Ida Hilden

12

1 reference

15 August 2017

Hermann Pelzer

13

1 reference

15 August 2017

Henrik Rahbek-Nielsen

14

1 reference

15 August 2017

Christina Jespersgaard

15

1 reference

15 August 2017

Are Bogsnes

16

1 reference

15 August 2017

Anette A Pedersen

17

1 reference

15 August 2017

Anne K Kristensen

18

1 reference

15 August 2017

Bernd Peschke

19

1 reference

15 August 2017

Wendy Kappers

20

1 reference

15 August 2017

Frederik Rode

21

1 reference

15 August 2017

Lars Thim

22

1 reference

15 August 2017

Mikael Tranholm

23

1 reference

15 August 2017

Mirella Ezban

24

1 reference

15 August 2017

Eva H N Olsen

25

1 reference

15 August 2017

Søren E Bjørn

26

1 reference

15 August 2017

language of work or name

English

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publication date

18 January 2013

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15 August 2017

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15 August 2017

121

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15 August 2017

11

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15 August 2017

2108-2116

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Modification of an exposed loop in the C1 domain reduces immune responses to factor VIII in hemophilia A mice

15 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3596971

Safety and prolonged activity of recombinant factor VIII Fc fusion protein in hemophilia A patients

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3596971

Pioneering designs for recombinant coagulation factors

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3596971

Requirements for immune recognition and processing of factor VIII by antigen-presenting cells

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3596971

Polymer therapeutics as nanomedicines: new perspectives

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3596971

Rational design of a fully active, long-acting PEGylated factor VIII for hemophilia A treatment

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3596971

Purification and characterization of a new recombinant factor VIII (N8).

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3596971

Primary prophylaxis in children with haemophilia.

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3596971

Efficacy and safety of certolizumab pegol plus methotrexate in active rheumatoid arthritis: the RAPID 2 study. A randomised controlled trial

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3596971

The pharmacology of PEGylation: balancing PD with PK to generate novel therapeutics

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3596971

Prophylaxis versus episodic treatment to prevent joint disease in boys with severe hemophilia

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3596971

Prophylaxis in adults with haemophilia

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3596971

Monomeric Fc fusions: impact on pharmacokinetic and biological activity of protein therapeutics

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3596971

Cloning, expression and characterization of a sialidase gene from Arthrobacter ureafaciens

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3596971

Effect of pegylation on pharmaceuticals

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3596971

A mouse model of severe von Willebrand disease: defects in hemostasis and thrombosis

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3596971

Further characterization of factor VIII-deficient mice created by gene targeting: RNA and protein studies

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3596971

Shear-dependent changes in the three-dimensional structure of human von Willebrand factor

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3596971

NMR solution structure of the recombinant tick anticoagulant protein (rTAP), a factor Xa inhibitor from the tick Ornithodoros moubata

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3596971

NMR structure determination of tick anticoagulant peptide (TAP).

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3596971

Enzymatic Properties of Neuraminidases from Arthrobacter ureafaciens

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3596971

Uptake of blood coagulation factor VIII by dendritic cells is mediated via its C1 domain

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3596971

Pharmacokinetics and pharmacodynamics of a new recombinant FVIII (N8) in haemophilia A mice

26 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3596971

Bioequivalence between two serum-free recombinant factor VIII preparations (N8 and ADVATE®)--an open-label, sequential dosing pharmacokinetic study in patients with severe haemophilia A.

26 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3596971

Functional characteristics of N8, a new recombinant FVIII.

26 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3596971

A ferric chloride induced arterial injury model used as haemostatic effect model

26 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3596971

Generation and biochemical characterization of glycoPEGylated factor VIIa derivatives.

26 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3596971

Hemostatic effect of recombinant factor VIIa, NN1731 and recombinant factor VIII on needle-induced joint bleeding in hemophilia A mice

26 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3596971

VWF protects FVIII from endocytosis by dendritic cells and subsequent presentation to immune effectors.

26 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3596971

GlycoPEGylation of recombinant therapeutic proteins produced in Escherichia coli.

26 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3596971

The Light Chain of Factor VIII Comprises a Binding Site for Low Density Lipoprotein Receptor-related Protein

26 November 2018

1 reference

12 December 2020

PEG-modified biopharmaceuticals

1 reference

12 December 2020

Role of the low density lipoprotein-related protein receptor in mediation of factor VIII catabolism

1 reference

12 December 2020

Elevated plasma factor VIII in a mouse model of low-density lipoprotein receptor-related protein deficiency

1 reference

12 December 2020

10.1182/BLOOD-2012-01-407494

Identifiers

DOI

1 reference

15 August 2017

1 reference

15 August 2017

PubMed publication ID

23335368

1 reference