(Q30428760)

21 June 2017

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title

Understanding and manipulating O6-methylguanine-DNA methyltransferase expression (English)

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21 June 2017

Pieper RO

1

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21 June 2017

language of work or name

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1 January 1997

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Pharmacology & Therapeutics

21 June 2017

published in

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21 June 2017

volume

74

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21 June 2017

issue

3

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21 June 2017

page(s)

285-297

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DNA synthesis with methylated poly(dC-dG) templates. Evidence for a competitive nature to miscoding by

21 June 2017

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8-Substituted O6-benzylguanine, substituted 6(4)-(benzyloxy)pyrimidine, and related derivatives as inactivators of human O6-alkylguanine-DNA alkyltransferase.

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O6-Alkylguanine-DNA alkyltransferase content in synchronised human cancer cells

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Defective repair of alkylated DNA by human tumour and SV40-transformed human cell strains

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Human tumor cell strains defective in the repair of alkylation damage.

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7 January 2021

Comparison of the inactivation of mammalian and bacterial O6-alkylguanine-DNA alkyltransferases by O6-benzylguanine and O6-methylguanine

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7 January 2021

The prevention of thymic lymphomas in transgenic mice by human O6-alkylguanine-DNA alkyltransferase

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DNA cross-linking and monoadduct repair in nitrosourea-treated human tumour cells

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7 January 2021

Inducibility of the DNA repair gene encoding O6-methylguanine-DNA methyltransferase in mammalian cells by DNA-damaging treatments

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7 January 2021

CpG islands in vertebrate genomes

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7 January 2021

O6 alkylguanine-DNA alkyltransferase activity in human myeloid cells

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7 January 2021

The Biological Actions and Therapeutic Applications of the B-Chloroethyl Amines and Sulfides

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Activation of human O6-alkylguanine-DNA alkyltransferase by DNA

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7 January 2021

Repair of O6-methylguanine, O6-ethylguanine, O6-isopropylguanine and O4-methylthymine in synthetic oligodeoxynucleotides by Escherichia coli ada gene O6-alkylguanine-DNA-alkyltransferase

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7 January 2021

Augmentation of adriamycin, melphalan, and cisplatin cytotoxicity in drug-resistant and -sensitive human ovarian carcinoma cell lines by buthionine sulfoximine mediated glutathione depletion.

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Characterization of the promoter region of the human O6-methylguanine-DNA methyltransferase gene

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Identification of a 59 bp enhancer located at the first exon/intron boundary of the human O6-methylguanine DNA methyltransferase gene

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7 January 2021

Expression and cloning of complementary DNA for a human enzyme that repairs O6-methylguanine in DNA.

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7 January 2021

A polymorphism at codon 160 of human O6 methylguanine-DNA methyltransferase gene in young patients with adult type cancers and functional assay

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7 January 2021

Methylation of the oestrogen receptor CpG island links ageing and neoplasia in human colon

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7 January 2021

Alteration of arginine-128 to alanine abolishes the ability of human O6-alkylguanine-DNA alkyltransferase to repair methylated DNA but has no effect on its reaction with O6-benzylguanine

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7 January 2021

HhaI methyltransferase flips its target base out of the DNA helix

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7 January 2021

The role of mRNA stability and transcription in O6-methylguanine DNA methyltransferase (MGMT) expression in Mer+ human tumor cells

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7 January 2021

Induction of O6-methylguanine-DNA-methyltransferase and N3-methyladenine-DNA-glycosylase in human cells exposed to DNA-damaging agents

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7 January 2021

The nuclear targeting and nuclear retention properties of a human DNA repair protein O6-methylguanine-DNA methyltransferase are both required for its nuclear localization: the possible implications

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7 January 2021

Specific amino acid sequences required for O6-methylguanine-DNA methyltransferase activity: analyses of three residues at or near the methyl acceptor site

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7 January 2021

The Modes of Decomposition of 1,3-Bis(2-chloroethyl)-1-nitrosourea and Related Compounds

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7 January 2021

Structural features of substituted purine derivatives compatible with depletion of human O6-alkylguanine-DNA alkyltransferase

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7 January 2021

Organization and expression of the human gene for O6-methylguanine-DNA methyltransferase

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7 January 2021

Chromosomal localization of human O6-methylguanine-DNA methyltransferase (MGMT) gene by in situ hybridization

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7 January 2021

Use of antibodies to human O6-alkylguanine-DNA alkyltransferase to study the content of this protein in cells treated with O6-benzylguanine or N-methyl-N'-nitro-N-nitrosoguanidine

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7 January 2021

Comparison of O-6-methylguanine DNA methyltransferase (MGMT) mRNA levels in Mer+ and Mer- human tumor cell lines containing the MGMT gene by the polymerase chain reaction technique

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7 January 2021

Methylation of CpG island transcription factor binding sites is unnecessary for aberrant silencing of the human MGMT gene

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7 January 2021

Localization of methylation sites in the human O6-methylguanine-DNA methyltransferase promoter: correlation with gene suppression

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7 January 2021

A comparative study of the biochemical properties of human and mouse recombinant O6-methylguanine-DNA methyltransferases

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7 January 2021

Isolation and partial characterization of murine O6-alkylguanine-DNA-alkyltransferase: comparative sequence and structural properties

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7 January 2021

Incision at O6-methylguanine:thymine mispairs in DNA by extracts of human cells

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7 January 2021

Ubiquitination-dependent proteolysis of O6-methylguanine-DNA methyltransferase in human and murine tumor cells following inactivation with O6-benzylguanine or 1,3-bis(2-chloroethyl)-1-nitrosourea

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7 January 2021

Gene amplification affecting O(6)-alkylguanine-DNA alkyltransferase activity is not detected in nitrosourea resistant or sensitive human cell lines

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7 January 2021

Inactive O6-methylguanine-DNA methyltransferase in human cells

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7 January 2021

Pretreatment of human colon tumor cells with DNA methylating agents inhibits their ability to repair chloroethyl monoadducts.

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7 January 2021

10.1016/S0163-7258(97)00003-X

Identifiers

DOI

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21 June 2017

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