(Q30429980)

English

Calpain mediates pulmonary vascular remodeling in rodent models of pulmonary hypertension, and its inhibition attenuates pathologic features of disease

scientific article

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scholarly article

1 reference

Europe PubMed Central

PMC publication ID

7 September 2017

Calpain mediates pulmonary vascular remodeling in rodent models of pulmonary hypertension, and its inhibition attenuates pathologic features of disease (English)

1 reference

Europe PubMed Central

PMC publication ID

7 September 2017

arterial hypertension

1 reference

based on heuristic

inferred from title

pulmonary hypertension

1 reference

based on heuristic

inferred from title

microvasculature remodeling

1 reference

based on heuristic

inferred from title

6

1 reference

Europe PubMed Central

PMC publication ID

7 September 2017

author name string

Wanli Ma

1

1 reference

Europe PubMed Central

PMC publication ID

7 September 2017

Weihong Han

2

1 reference

Europe PubMed Central

PMC publication ID

7 September 2017

Peter A Greer

3

1 reference

Europe PubMed Central

PMC publication ID

7 September 2017

Rubin M Tuder

4

1 reference

Europe PubMed Central

PMC publication ID

7 September 2017

Haroldo A Toque

5

1 reference

Europe PubMed Central

PMC publication ID

7 September 2017

R William Caldwell

7

1 reference

Europe PubMed Central

PMC publication ID

7 September 2017

Yunchao Su

8

1 reference

Europe PubMed Central

PMC publication ID

7 September 2017

language of work or name

0 references

publication date

17 October 2011

1 reference

Europe PubMed Central

PMC publication ID

7 September 2017

Journal of Clinical Investigation

1 reference

Europe PubMed Central

PMC publication ID

7 September 2017

121

1 reference

Europe PubMed Central

PMC publication ID

7 September 2017

11

1 reference

Europe PubMed Central

PMC publication ID

7 September 2017

4548-4566

1 reference

Europe PubMed Central

PMC publication ID

7 September 2017

describes a project that uses

1 reference

Europe PubMed Central

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC3204840/fullTextXML

based on heuristic

inferred from PubMed Central ID database lookup

Intracrine signaling mechanisms of activin A and TGF-β.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3204840

20 June 2018

The calpain inhibitor calpeptin prevents bleomycin-induced pulmonary fibrosis in mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3204840

20 June 2018

Two distinct regions of latency-associated peptide coordinate stability of the latent transforming growth factor-beta1 complex

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3204840

20 June 2018

Role of epidermal growth factor receptor in ovine fetal pulmonary vascular remodeling following exposure to high altitude long-term hypoxia

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3204840

20 June 2018

Animal models of pulmonary arterial hypertension: the hope for etiological discovery and pharmacological cure.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3204840

20 June 2018

Pathology of pulmonary arterial hypertension

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3204840

20 June 2018

Identification of c-Src tyrosine kinase substrates in platelet-derived growth factor receptor signaling

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3204840

20 June 2018

Inflammation, growth factors, and pulmonary vascular remodeling

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3204840

20 June 2018

Rosiglitazone attenuates chronic hypoxia-induced pulmonary hypertension in a mouse model

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3204840

20 June 2018

Endocytic regulation of TGF-beta signaling

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3204840

20 June 2018

An ezrin/calpain/PI3K/AMPK/eNOSs1179 signaling cascade mediating VEGF-dependent endothelial nitric oxide production

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3204840

20 June 2018

Calpain small-1 modulates Akt/FoxO3A signaling and apoptosis through PP2A.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3204840

20 June 2018

Molecular pathogenesis of pulmonary arterial hypertension

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3204840

20 June 2018

Activation of TGF-beta within cultured hepatocytes and in liver injury leads to intracrine signaling with expression of connective tissue growth factor

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3204840

20 June 2018

Role of the TGF-beta/Alk5 signaling pathway in monocrotaline-induced pulmonary hypertension

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3204840

20 June 2018

Pathobiology of pulmonary hypertension

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3204840

20 June 2018

Nicotine, lung and cancer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3204840

20 June 2018

Endothelin-1 mediates hypoxia-induced increases in vascular collagen in the newborn mouse lung

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3204840

20 June 2018

Sequential degradation of alphaII and betaII spectrin by calpain in glutamate or maitotoxin-stimulated cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3204840

20 June 2018

Hypoxia-induced pulmonary vascular remodeling: cellular and molecular mechanisms

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3204840

20 June 2018

Calpain-2 regulation of VEGF-mediated angiogenesis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3204840

20 June 2018

Calpain inhibitor MDL28170 modulates Abeta formation by inhibiting the formation of intermediate Abeta46 and protecting Abeta from degradation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3204840

20 June 2018

Tumor metastasis in an orthotopic murine model of head and neck cancer: possible role of TGF-beta 1 secreted by the tumor cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3204840

20 June 2018

Reversal of experimental pulmonary hypertension by PDGF inhibition

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3204840

20 June 2018

Regulating cell migration: calpains make the cut.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3204840

20 June 2018

Involvement of calpain-calpastatin in cigarette smoke-induced inhibition of lung endothelial nitric oxide synthase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3204840

20 June 2018

Overexpression of calpastatin inhibits L8 myoblast fusion

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3204840

20 June 2018

Androgens repress the expression of the angiogenesis inhibitor thrombospondin-1 in normal and neoplastic prostate

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3204840

20 June 2018

Differential compartmentalization of the calpain/calpastatin network with the endoplasmic reticulum and Golgi apparatus

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3204840

20 June 2018

Interaction of calpastatin with calpain: a review

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3204840

20 June 2018

Cellular and molecular pathobiology of pulmonary arterial hypertension

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3204840

20 June 2018

Cigarette smoke extract inhibits angiogenesis of pulmonary artery endothelial cells: the role of calpain

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3204840

20 June 2018

Structure, activation, and biology of calpain

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3204840

20 June 2018

The calpain system

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3204840

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3204840

20 June 2018

Cutting to the chase: calpain proteases in cell motility

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3204840

20 June 2018

The structure of calpain.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3204840

20 June 2018

Membrane proximal ERK signaling is required for M-calpain activation downstream of epidermal growth factor receptor signaling.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3204840

20 June 2018

Molecular characterization of human tensin

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3204840

20 June 2018

Disruption of the murine calpain small subunit gene, Capn4: calpain is essential for embryonic development but not for cell growth and division

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3204840

20 June 2018

Role of basal calcium in the EGF activation of MAP kinases

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3204840

20 June 2018

Hypoxia-specific upregulation of calpain activity and gene expression in pulmonary artery endothelial cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3204840

20 June 2018

Thrombospondin-1 is a major activator of TGF-beta1 in vivo

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3204840

20 June 2018

Cell-associated activation of latent transforming growth factor-beta by calpain

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3204840

20 June 2018

PDGF-stimulated calcium influx changes during in vitro cell transformation.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3204840

20 June 2018

Tenascin-C, proliferation and subendothelial fibronectin in progressive pulmonary vascular disease.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3204840

20 June 2018

Intracellular demonstration of active TGFbeta1 in B cells and plasma cells of autoimmune mice. IgG-bound TGFbeta1 suppresses neutrophil function and host defense against Staphylococcus aureus infection

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3204840

20 June 2018

Calpain: novel family members, activation, and physiologic function

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3204840

20 June 2018

Reperfusion of Rat Heart After Brief Ischemia Induces Proteolysis of Calspectin (Nonerythroid Spectrin or Fodrin) by Calpain

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3204840

20 June 2018

Polyamines and epidermal growth factor in monocrotaline-induced pulmonary hypertension

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3204840

20 June 2018

TGF-beta activity protects against inflammatory aortic aneurysm progression and complications in angiotensin II-infused mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3204840

26 November 2018

Biphasic effects of selective inhibition of transforming growth factor beta1 activin receptor-like kinase on LPS-induced lung injury

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3204840

26 November 2018

Effects of rho-kinase inhibition on pulmonary hypertension, lung growth, and structure in neonatal rats chronically exposed to hypoxia

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3204840

26 November 2018

Role of epidermal growth factor inhibition in experimental pulmonary hypertension.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3204840

26 November 2018

Growth factors and interleukin-6 across the lung circulation in pulmonary hypertension.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3204840

26 November 2018

Calpain expression and activity during lens fiber cell differentiation.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3204840

26 November 2018

Altered bone morphogenetic protein and transforming growth factor-beta signaling in rat models of pulmonary hypertension: potential for activin receptor-like kinase-5 inhibition in prevention and progression of disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3204840

26 November 2018

Activin-like kinase 5 (ALK5) mediates abnormal proliferation of vascular smooth muscle cells from patients with familial pulmonary arterial hypertension and is involved in the progression of experimental pulmonary arterial hypertension induced by mo

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3204840

26 November 2018

Conditional disruption of ubiquitous calpains in the mouse.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3204840

26 November 2018

Use of recombinant calpain-2 siRNA adenovirus to assess calpain-2 modulation of lung endothelial cell migration and proliferation.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3204840

26 November 2018

Ubiquitous calpains promote both apoptosis and survival signals in response to different cell death stimuli.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3204840

26 November 2018

Dominant negative mutation of the TGF-beta receptor blocks hypoxia-induced pulmonary vascular remodeling.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3204840

26 November 2018

Epidermal growth factor receptor blockade mediates smooth muscle cell apoptosis and improves survival in rats with pulmonary hypertension

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3204840

26 November 2018

Calpain inhibition decreases endothelin-1 levels and pulmonary hypertension after cardiopulmonary bypass with deep hypothermic circulatory arrest

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3204840

26 November 2018

Protective effect of MDL28170 against thioacetamide-induced acute liver failure in mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3204840

26 November 2018

Calpain inhibition decreases the growth rate of mammalian cell colonies

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3204840

26 November 2018

Regional distribution and time-course of calpain activation following kainate-induced seizure activity in adult rat brain.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3204840

26 November 2018

Role of calpain in hypoxic inhibition of nitric oxide synthase activity in pulmonary endothelial cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/22005303

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Alterations of growth factor transcripts in rat lungs during development of monocrotaline-induced pulmonary hypertension

1 reference

https://pubmed.ncbi.nlm.nih.gov/22005303

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Excess collagen in hypertensive pulmonary arteries decreases vascular distensibility

1 reference

https://pubmed.ncbi.nlm.nih.gov/22005303

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Hepatocellular carcinoma cells resist necrosis during anoxia by preventing phospholipase-mediated calpain activation

1 reference

https://pubmed.ncbi.nlm.nih.gov/22005303

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Active collagen synthesis by pulmonary arteries in pulmonary hypertension complicated by congenital diaphragmatic hernia

1 reference

https://pubmed.ncbi.nlm.nih.gov/22005303

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Impaired transforming growth factor-beta signaling in idiopathic pulmonary arterial hypertension

1 reference

https://pubmed.ncbi.nlm.nih.gov/22005303

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

PTEN as a new agent in the fight against fibrogenesis

1 reference

https://pubmed.ncbi.nlm.nih.gov/22005303

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Flow cytometric measurement of calpain activity in living cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/22005303

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1172/JCI57734

1 reference

Europe PubMed Central

PMC publication ID

7 September 2017

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

7 September 2017

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

7 September 2017

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