(Q30441412)

21 June 2017

1 reference

title

Obstructive nephropathy: towards biomarker discovery and gene therapy (English)

1 reference

21 June 2017

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0 references

obstructive nephropathy

1 reference

Robert L Chevalier

1

1 reference

21 June 2017

1 March 2006

1 reference

Nature Clinical Practice Nephrology

21 June 2017

1 reference

21 June 2017

2

1 reference

21 June 2017

3

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21 June 2017

157-168

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Chronic renal insufficiency in children: the 2001 Annual Report of the NAPRTCS.

21 June 2017

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEPH0098

7 January 2021

Congenital urinary tract obstruction: Proceedings of the State-Of-The-Art Strategic Planning Workshop—National Institutes of Health, Bethesda, Maryland, USA, 11–12 March 2002

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEPH0098

7 January 2021

Evidence that fibroblasts derive from epithelium during tissue fibrosis

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEPH0098

7 January 2021

Role of angiotensin II in chronic ureteral obstruction.

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEPH0098

7 January 2021

Paradigm shift from classic anatomic theories to contemporary cell biological views of CAKUT.

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEPH0098

7 January 2021

Rapid communication. Enalapril decreases nuclear factor kappa B activation in the kidney with ureteral obstruction

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEPH0098

7 January 2021

Obstructive nephropathy and renal fibrosis

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEPH0098

7 January 2021

Novel nuclear factor kappa B activation inhibitor prevents inflammatory injury in unilateral ureteral obstruction

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEPH0098

7 January 2021

Role of renin-angiotensin system and nuclear factor-kappaB in the obstructed kidney of rats with unilateral ureteral obstruction

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEPH0098

7 January 2021

Y-27632 prevents tubulointerstitial fibrosis in mouse kidneys with unilateral ureteral obstruction

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEPH0098

7 January 2021

Selectins mediate macrophage infiltration in obstructive nephropathy in newborn mice

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEPH0098

7 January 2021

P-selectin-dependent macrophage migration into the tubulointerstitium in unilateral ureteral obstruction

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEPH0098

7 January 2021

Cerebroside sulfotransferase deficiency ameliorates L-selectin-dependent monocyte infiltration in the kidney after ureteral obstruction

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEPH0098

7 January 2021

Role of leukocyte adhesion molecules in monocyte/ macrophage infiltration in weanling rats with unilateral ureteral obstruction

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEPH0098

7 January 2021

Distinct roles of Mac-1 and its counter-receptors in neonatal obstructive nephropathy

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEPH0098

7 January 2021

Effects of ICAM-1 antisense oligonucleotide on the tubulointerstitium in mice with unilateral ureteral obstruction

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEPH0098

7 January 2021

Genetically modified bone marrow-derived vehicle cells site specifically deliver an anti-inflammatory cytokine to inflamed interstitium of obstructive nephropathy

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEPH0098

7 January 2021

Gene therapy via blockade of monocyte chemoattractant protein-1 for renal fibrosis.

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEPH0098

7 January 2021

MCP-1 is up-regulated in unstressed and stressed HO-1 knockout mice: Pathophysiologic correlates

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEPH0098

7 January 2021

Reduced macrophage recruitment, proliferation, and activation in colony-stimulating factor-1-deficient mice results in decreased tubular apoptosis during renal inflammation

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEPH0098

7 January 2021

Blockade of CCR2 ameliorates progressive fibrosis in kidney.

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEPH0098

7 January 2021

Chemokine receptor CCR1 but not CCR5 mediates leukocyte recruitment and subsequent renal fibrosis after unilateral ureteral obstruction

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEPH0098

7 January 2021

A chemokine receptor CCR-1 antagonist reduces renal fibrosis after unilateral ureter ligation

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEPH0098

7 January 2021

A2A adenosine receptor agonist and PDE4 inhibition delays inflammation but fails to reduce injury in experimental obstructive nephropathy

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEPH0098

7 January 2021

Retinoid agonist isotretinoin ameliorates obstructive renal injury

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEPH0098

7 January 2021

Interstitial fibrosis of unilateral ureteral obstruction is exacerbated in kidneys of mice lacking the gene for inducible nitric oxide synthase

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEPH0098

7 January 2021

Liposome-mediated transfer of nitric oxide synthase gene improves renal function in ureteral obstruction in rats.

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEPH0098

7 January 2021

Promise for gene therapy in obstructive nephropathy

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEPH0098

7 January 2021

Obstructive uropathy in the mouse: role of osteopontin in interstitial fibrosis and apoptosis

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEPH0098

7 January 2021

CD44 deficiency increases tubular damage but reduces renal fibrosis in obstructive nephropathy.

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEPH0098

7 January 2021

Urokinase receptor modulates cellular and angiogenic responses in obstructive nephropathy.

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEPH0098

7 January 2021

Absence of angiotensin II type 1 receptor in bone marrow-derived cells is detrimental in the evolution of renal fibrosis

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEPH0098

7 January 2021

Ureteral obstruction in neonatal mice elicits segment-specific tubular cell responses leading to nephron loss.

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEPH0098

7 January 2021

Interaction of nitric oxide and transforming growth factor-beta1 induced by angiotensin II and mechanical stretch in rat renal tubular epithelial cells

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEPH0098

7 January 2021

Transforming growth factor-beta1 potentiates renal tubular epithelial cell death by a mechanism independent of Smad signaling

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEPH0098

7 January 2021

Antibody to transforming growth factor-beta ameliorates tubular apoptosis in unilateral ureteral obstruction

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEPH0098

7 January 2021

Cellular overexpression of heme oxygenase-1 up-regulates p21 and confers resistance to apoptosis

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEPH0098

7 January 2021

Mechanical deformation induced apoptosis in human proximal renal tubular epithelial cells is caspase dependent

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEPH0098

7 January 2021

Role of nitric oxide in renal tubular apoptosis of unilateral ureteral obstruction

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEPH0098

7 January 2021

Obstructive nephropathy in the neonatal rat is attenuated by epidermal growth factor

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEPH0098

7 January 2021

Renal tubulointerstitial injury from ureteral obstruction in the neonatal rat is attenuated by IGF-1.

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEPH0098

7 January 2021

Heparin-binding EGF-like growth factor is up-regulated in the obstructed kidney in a cell- and region-specific manner and acts to inhibit apoptosis

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEPH0098

7 January 2021

Epidermal growth factor potentiates renal cell death in hydronephrotic neonatal mice, but cell survival in rats

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEPH0098

7 January 2021

Macrophages induce apoptosis in proximal tubule cells

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEPH0098

7 January 2021

Unilateral ureteral obstruction impairs renal antioxidant enzyme activation during sodium depletion

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEPH0098

7 January 2021

Activation of ERK in renal fibrosis after unilateral ureteral obstruction: modulation by antioxidants.

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEPH0098

7 January 2021

Growth factor-mediated phosphorylation of proapoptotic BAD reduces tubule cell death in vitro and in vivo

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEPH0098

7 January 2021

Chronic ureteral obstruction in the rat suppresses renal tubular Bcl-2 and stimulates apoptosis

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEPH0098

7 January 2021

Hepatocyte growth factor gene therapy retards the progression of chronic obstructive nephropathy

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEPH0098

7 January 2021

Osteogenic protein-1 prevents renal fibrogenesis associated with ureteral obstruction.

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEPH0098

7 January 2021

The cyclin-dependent kinase inhibitor p27Kip1 safeguards against inflammatory injury

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEPH0098

7 January 2021

Absence of decorin adversely influences tubulointerstitial fibrosis of the obstructed kidney by enhanced apoptosis and increased inflammatory reaction

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEPH0098

7 January 2021

Reduced angiotensinogen expression attenuates renal interstitial fibrosis in obstructive nephropathy in mice

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEPH0098

7 January 2021

Effects of suppressing intrarenal angiotensinogen on renal transforming growth factor-beta1 expression in acute ureteral obstruction

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEPH0098

7 January 2021

In vivo bradykinin B2 receptor activation reduces renal fibrosis

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEPH0098

7 January 2021

Quantification of TGF-beta1 mRNA along rat nephron in obstructive nephropathy

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEPH0098

7 January 2021

Increased expression of TGF-beta1 but not of its receptors contributes to human obstructive nephropathy

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEPH0098

7 January 2021

Transforming growth factor-beta 1 antisense oligodeoxynucleotides block interstitial fibrosis in unilateral ureteral obstruction

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEPH0098

7 January 2021

Genetic programs of epithelial cell plasticity directed by transforming growth factor-beta

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEPH0098

7 January 2021

Down-regulation of Smad7 expression by ubiquitin-dependent degradation contributes to renal fibrosis in obstructive nephropathy in mice

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEPH0098

7 January 2021

Targeted disruption of TGF-β1/Smad3 signaling protects against renal tubulointerstitial fibrosis induced by unilateral ureteral obstruction

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEPH0098

7 January 2021

Smad3 deficiency attenuates renal fibrosis, inflammation,and apoptosis after unilateral ureteral obstruction.

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEPH0098

7 January 2021

Inhibition of renal fibrosis by gene transfer of inducible Smad7 using ultrasound-microbubble system in rat UUO model

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEPH0098

7 January 2021

Downregulation of Smad transcriptional corepressors SnoN and Ski in the fibrotic kidney: an amplification mechanism for TGF-beta1 signaling

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEPH0098

7 January 2021

Hepatocyte growth factor suppresses renal interstitial myofibroblast activation and intercepts Smad signal transduction

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEPH0098

7 January 2021

A novel mechanism by which hepatocyte growth factor blocks tubular epithelial to mesenchymal transition

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEPH0098

7 January 2021

Regulation of the mammalian cell cycle: a model of the G1-to-S transition

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEPH0098

7 January 2021

AT1A-mediated activation of kidney JNK1 and SMAD2 in obstructive uropathy: preservation of kidney tissue mass using candesartan

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEPH0098

7 January 2021

Hepatocyte growth factor gene therapy and angiotensin II blockade synergistically attenuate renal interstitial fibrosis in mice

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEPH0098

7 January 2021

Introduction of DNA enzyme for Egr-1 into tubulointerstitial fibroblasts by electroporation reduced interstitial alpha-smooth muscle actin expression and fibrosis in unilateral ureteral obstruction (UUO) rats

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEPH0098

7 January 2021

Obstructive uropathy in mice and humans: potential role for PDGF-D in the progression of tubulointerstitial injury

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEPH0098

7 January 2021

Role of connective tissue growth factor in profibrotic action of transforming growth factor-beta: a potential target for preventing renal fibrosis

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEPH0098

7 January 2021

Reduction in connective tissue growth factor by antisense treatment ameliorates renal tubulointerstitial fibrosis

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEPH0098

7 January 2021

The role of p38alpha mitogen-activated protein kinase activation in renal fibrosis

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEPH0098

7 January 2021

Plasminogen activator inhibitor-1 and tissue-type plasminogen activator are up-regulated during unilateral ureteral obstruction in adult rats

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEPH0098

7 January 2021

PAI-1 deficiency attenuates the fibrogenic response to ureteral obstruction

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEPH0098

7 January 2021

Multifunctionality of PAI-1 in fibrogenesis: evidence from obstructive nephropathy in PAI-1-overexpressing mice.

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEPH0098

7 January 2021

Disruption of tissue-type plasminogen activator gene in mice reduces renal interstitial fibrosis in obstructive nephropathy

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEPH0098

7 January 2021

Urokinase receptor deficiency accelerates renal fibrosis in obstructive nephropathy.

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEPH0098

7 January 2021

Cyclin kinase inhibitor p21CIP1/WAF1 limits interstitial cell proliferation following ureteric obstruction

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEPH0098

7 January 2021

Bone morphogenetic protein-7 improves renal fibrosis and accelerates the return of renal function

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEPH0098

7 January 2021

Kielin/chordin-like protein, a novel enhancer of BMP signaling, attenuates renal fibrotic disease

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEPH0098

7 January 2021

Connective-tissue growth factor (CTGF) modulates cell signalling by BMP and TGF-beta

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEPH0098

7 January 2021

Forestalling fibrosis

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEPH0098

7 January 2021

Biomarkers of congenital obstructive nephropathy: past, present and future

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEPH0098

7 January 2021

Role of endogenous nitric oxide in unilateral ureteropelvic junction obstruction in children.

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEPH0098

7 January 2021

The expression of epidermal growth factor and transforming growth factor-beta1 in the stenotic tissue of congenital pelvi-ureteric junction obstruction in children

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEPH0098

7 January 2021

MCP-1 and EGF renal expression and urine excretion in human congenital obstructive nephropathy

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEPH0098

7 January 2021

Urinary concentration and tissue messenger RNA expression of monocyte chemoattractant protein-1 as an indicator of the degree of hydronephrotic atrophy in partial ureteral obstruction

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEPH0098

7 January 2021

Factors associated with the outcomes of children with unilateral ureteropelvic junction obstruction.

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEPH0098

7 January 2021

Characterization of an animal model of spontaneous congenital unilateral obstructive uropathy by cDNA microarray analysis.

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEPH0098

7 January 2021

Perinatal obstructive nephropathy

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEPH0098

7 January 2021

Recovery following relief of unilateral ureteral obstruction in the neonatal rat.

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEPH0098

7 January 2021

Salutary role for angiotensin in partial urinary tract obstruction

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEPH0098

7 January 2021

Obstructive nephropathy: insights from genetically engineered animals

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEPH0098

7 January 2021

Gene therapy for renal diseases: its potential and limitation

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEPH0098

7 January 2021

Liposome-mediated gene therapy in the kidney

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEPH0098

7 January 2021

Identifiers

DOI

10.1038/NCPNEPH0098

1 reference

21 June 2017

1 reference

PubMed ID

16932414