(Q30441976)

21 June 2017

title

Mechanisms of disease: the role of GRK4 in the etiology of essential hypertension and salt sensitivity (English)

1 reference

21 June 2017

main subject

arterial hypertension

1 reference

inferred from title

essential hypertension

1 reference

Robin A Felder

1

1 reference

21 June 2017

Pedro A Jose

series ordinal

2

1 reference

21 June 2017

publication date

1 November 2006

1 reference

Nature Clinical Practice Nephrology

21 June 2017

published in

1 reference

21 June 2017

volume

2

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21 June 2017

issue

11

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21 June 2017

page(s)

637-650

1 reference

The Seventh Report of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure<SUBTITLE>The JNC 7 Report</SUBTITLE>

21 June 2017

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Proximal tubular angiotensin II levels and renal functional responses to AT1 receptor blockade in nonclipped kidneys of Goldblatt hypertensive rats

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Analysis of arterial pressure regulating systems in renal post-transplantation hypertension

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Impaired renal D(1)-like and D(2)-like dopamine receptor interaction in the spontaneously hypertensive rat.

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7 January 2021

G protein-coupled receptors form stable complexes with inwardly rectifying potassium channels and adenylyl cyclase

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7 January 2021

D2-like receptor-mediated inhibition of Na+-K+-ATPase activity is dependent on the opening of K+ channels

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7 January 2021

Genome scan for blood pressure in Dutch dyslipidemic families reveals linkage to a locus on chromosome 4p.

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7 January 2021

Dopamine and the kidney: a role in hypertension?

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7 January 2021

Na+-independent transporters, LAT-2 and b0,+, exchange L-DOPA with neutral and basic amino acids in two clonal renal cell lines

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7 January 2021

The dopamine precursor L-dihydroxyphenylalanine is transported by the amino acid transporters rBAT and LAT2 in renal cortex

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7 January 2021

Renalase is a novel, soluble monoamine oxidase that regulates cardiac function and blood pressure

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7 January 2021

Effect of inhibition of MAO and COMT on intrarenal dopamine and serotonin and on renal function

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7 January 2021

Reduced natriuretic response to acute sodium loading in COMT gene deleted mice

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https://api.crossref.org/works/10.1038%2FNCPNEPH0301

7 January 2021

Intrarenal dopamine production and distribution in the rat. Physiological control of sodium excretion

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https://api.crossref.org/works/10.1038%2FNCPNEPH0301

7 January 2021

Deficiency of renal dopaminergic-dependent natriuretic response to acute sodium load in black salt-sensitive subjects in contrast to salt-resistant subjects

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https://api.crossref.org/works/10.1038%2FNCPNEPH0301

7 January 2021

High urinary dopa and low urinary dopamine-to-dopa ratio in salt-sensitive hypertension

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7 January 2021

Peripheral dopamine synthesis and metabolism in spontaneously hypertensive rats

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7 January 2021

Increased urinary dopamine excretion in young patients with essential hypertension

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7 January 2021

Over-expression of renal LAT1 and LAT2 and enhanced L-DOPA uptake in SHR immortalized renal proximal tubular cells.

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https://api.crossref.org/works/10.1038%2FNCPNEPH0301

7 January 2021

Gene-targeting studies of the renin-angiotensin system: mechanisms of hypertension and cardiovascular disease

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https://api.crossref.org/works/10.1038%2FNCPNEPH0301

7 January 2021

Tissue-specific regulation of type 1 angiotensin II receptor mRNA levels in the rat.

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEPH0301

7 January 2021

The effect of dopamine receptor blockade on natriuresis is dependent on the degree of hypervolemia

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEPH0301

7 January 2021

Effect of dopamine D3 receptor blockade on renal function and glomerular size in diabetic rats

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEPH0301

7 January 2021

Role of the D1A dopamine receptor in the pathogenesis of genetic hypertension

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEPH0301

7 January 2021

Disruption of the dopamine D3 receptor gene produces renin-dependent hypertension

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEPH0301

7 January 2021

Renal dopamine receptors in health and hypertension.

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEPH0301

7 January 2021

Dopamine regulation of renal Na+,K(+)-ATPase activity is lacking in Dahl salt-sensitive rats

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEPH0301

7 January 2021

Differential human renal tubular responses to dopamine type 1 receptor stimulation are determined by blood pressure status

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEPH0301

7 January 2021

Dopamine-1 receptor coupling defect in renal proximal tubule cells in hypertension

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEPH0301

7 January 2021

On the role of renal alpha-adrenergic receptors in spontaneously hypertensive rats

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEPH0301

7 January 2021

Defective dopamine-1 receptor adenylate cyclase coupling in the proximal convoluted tubule from the spontaneously hypertensive rat

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEPH0301

7 January 2021

Defective D1-like receptor-mediated inhibition of the Cl-/HCO3- exchanger in immortalized SHR proximal tubular epithelial cells

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEPH0301

7 January 2021

Dopamine fails to inhibit renal tubular sodium pump in hypertensive rats

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEPH0301

7 January 2021

Interaction of angiotensin II type 1 and D5 dopamine receptors in renal proximal tubule cells

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEPH0301

7 January 2021

Perturbation of D1 dopamine and AT1 receptor interaction in spontaneously hypertensive rats

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEPH0301

7 January 2021

alpha 2-Adrenoceptors potentiate angiotensin II- and vasopressin-induced renal vasoconstriction in spontaneously hypertensive rats

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEPH0301

7 January 2021

Gialpha3 protein-coupled dopamine D3 receptor-mediated inhibition of renal NHE3 activity in SHR proximal tubular cells is a PLC-PKC-mediated event.

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEPH0301

7 January 2021

Enhanced activation of RhoA by angiotensin II in SHR preglomerular microvascular smooth muscle cells

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEPH0301

7 January 2021

Redox-dependent signalling by angiotensin II and vascular remodelling in hypertension

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEPH0301

7 January 2021

Gq-coupled receptor agonists mediate cardiac hypertrophy via the vasculature

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https://api.crossref.org/works/10.1038%2FNCPNEPH0301

7 January 2021

G protein polymorphisms in hypertension, atherosclerosis, and diabetes

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEPH0301

7 January 2021

D(1) dopamine receptor regulation of NHE3 during development in spontaneously hypertensive rats

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEPH0301

7 January 2021

Regulation of Blood Pressure by Dopamine Receptors

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEPH0301

7 January 2021

Renal dopamine-1 receptors in hypertensive inbred rat strains with and without hyperactivity

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEPH0301

7 January 2021

Salt intake and sensitivity of intestinal and renal Na+-K+ atpase to inhibition by dopamine in spontaneous hypertensive and Wistar-Kyoto rats

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEPH0301

7 January 2021

Impaired renal vascular response to a D1-like receptor agonist but not to an ACE inhibitor in conscious spontaneously hypertensive rats

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEPH0301

7 January 2021

Defective G protein activation of the cAMP pathway in rat kidney during genetic hypertension

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEPH0301

7 January 2021

Aberrant D1 and D3 dopamine receptor transregulation in hypertension

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEPH0301

7 January 2021

Fenoldopam: a selective peripheral dopamine-receptor agonist for the treatment of severe hypertension

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEPH0301

7 January 2021

Elevated renal cortical calmodulin-dependent protein kinase activity and blood pressure

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEPH0301

7 January 2021

Alteration of association of agonist-activated renal D1(A) dopamine receptors with G proteins in proximal tubules of the spontaneously hypertensive rat

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEPH0301

7 January 2021

Dopamine(1) receptor, G(salpha), and Na(+)-H(+) exchanger interactions in the kidney in hypertension

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEPH0301

7 January 2021

Dopamine inhibits renal Na+:HCO3- cotransporter in rabbits and normotensive rats but not in spontaneously hypertensive rats

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEPH0301

7 January 2021

The 14-3-3 protein translates the NA+,K+-ATPase {alpha}1-subunit phosphorylation signal into binding and activation of phosphoinositide 3-kinase during endocytosis

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEPH0301

7 January 2021

Intracellular Na+ regulates dopamine and angiotensin II receptors availability at the plasma membrane and their cellular responses in renal epithelia

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEPH0301

7 January 2021

Altered subcellular distribution of Na+,K+-ATPase in proximal tubules in young spontaneously hypertensive rats

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEPH0301

7 January 2021

Hypertension-linked mutation in the adducin alpha-subunit leads to higher AP2-mu2 phosphorylation and impaired Na+,K+-ATPase trafficking in response to GPCR signals and intracellular sodium

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEPH0301

7 January 2021

ACE and α-Adducin Polymorphism as Markers of Individual Response to Diuretic Therapy

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEPH0301

7 January 2021

New strategies for identifying gene-gene interactions in hypertension

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEPH0301

7 January 2021

[Ca2+]i determines the effects of protein kinases A and C on activity of rat renal Na+,K+-ATPase

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEPH0301

7 January 2021

Dual signaling regulated by calcyon, a D1 dopamine receptor interacting protein

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEPH0301

7 January 2021

Dopamine D3 receptor-mediated inhibition of Na+/H+ exchanger activity in normotensive and spontaneously hypertensive rat proximal tubular epithelial cells

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEPH0301

7 January 2021

D3 dopamine receptor directly interacts with D1 dopamine receptor in immortalized renal proximal tubule cells

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEPH0301

7 January 2021

Dopamine D1 receptor gene polymorphism is associated with essential hypertension

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEPH0301

7 January 2021

Kidney angiotensin II receptors and converting enzyme in neonatal and adult Wistar-Kyoto and spontaneously hypertensive rats.

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEPH0301

7 January 2021

Potentiation by enalaprilat of fenoldopam-evoked natriuresis is due to blockade of intrarenal production of angiotensin-II in rats

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEPH0301

7 January 2021

Bromocriptine regulates angiotensin II response on sodium pump in proximal tubules

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEPH0301

7 January 2021

Rat strain effects of AT1 receptor activation on D1 dopamine receptors in immortalized renal proximal tubule cells

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEPH0301

7 January 2021

Dopamine decreases expression of type-1 angiotensin II receptors in renal proximal tubule

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEPH0301

7 January 2021

Meta-analysis of genome-wide scans for hypertension and blood pressure in Caucasians shows evidence of susceptibility regions on chromosomes 2 and 3

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEPH0301

7 January 2021

The role of phosphorylation in D1 dopamine receptor desensitization: evidence for a novel mechanism of arrestin association

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEPH0301

7 January 2021

The D1 dopamine receptor is constitutively phosphorylated by G protein-coupled receptor kinase 4

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEPH0301

7 January 2021

Differential regulation of dopamine D1A receptor responsiveness by various G protein-coupled receptor kinases

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEPH0301

7 January 2021

G protein-coupled receptor kinase 4 gene variants in human essential hypertension

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEPH0301

7 January 2021

Regulation of G protein-coupled receptor kinases and arrestins during receptor desensitization

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEPH0301

7 January 2021

Pathophysiological roles of G-protein-coupled receptor kinases

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEPH0301

7 January 2021

Non-visual GRKs: are we seeing the whole picture?

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEPH0301

7 January 2021

Rat G protein-coupled receptor kinase GRK4: identification, functional expression, and differential tissue distribution of two splice variants

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEPH0301

7 January 2021

G-Protein-coupled receptor kinase activity in hypertension : increased vascular and lymphocyte G-protein receptor kinase-2 protein expression.

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEPH0301

7 January 2021

The impact of blunted beta-adrenergic responsiveness on growth regulatory pathways in hypertension

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEPH0301

7 January 2021

Vascular-targeted overexpression of G protein-coupled receptor kinase-2 in transgenic mice attenuates beta-adrenergic receptor signaling and increases resting blood pressure

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEPH0301

7 January 2021

Vascular smooth muscle overexpression of G protein-coupled receptor kinase 5 elevates blood pressure, which segregates with sex and is dependent on Gi-mediated signaling

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEPH0301

7 January 2021

G Protein-coupled Receptor Kinase 5 in Cultured Vascular Smooth Muscle Cells and Rat Aorta

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEPH0301

7 January 2021

Characterization of the G Protein-coupled Receptor Kinase GRK4

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEPH0301

7 January 2021

Dopaminergic supersensitivity in G protein-coupled receptor kinase 6-deficient mice

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEPH0301

7 January 2021

The G protein-coupled receptor kinase 4 gene affects blood pressure in young normotensive twins

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEPH0301

7 January 2021

Desensitization of human renal D1 dopamine receptors by G protein-coupled receptor kinase 4

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEPH0301

7 January 2021

Are we beta-ARKing up the wrong tree? Casein kinase 1 alpha provides an additional pathway for GPCR phosphorylation

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEPH0301

7 January 2021

Monoclonal antibodies reveal receptor specificity among G-protein-coupled receptor kinases

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEPH0301

7 January 2021

Regulation of G-protein-coupled receptor kinase subtypes by calcium sensor proteins

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEPH0301

7 January 2021

Association of the alpha-adducin locus with essential hypertension

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEPH0301

7 January 2021

Autosomal genome scan for loci linked to blood pressure levels and trends since childhood: the Bogalusa Heart Study

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEPH0301

7 January 2021

Association between the alpha-adducin gene and hypertension in the HyperGEN Study

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEPH0301

7 January 2021

Mice lacking D5 dopamine receptors have increased sympathetic tone and are hypertensive

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEPH0301

7 January 2021

Functional genomics of the dopaminergic system in hypertension

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEPH0301

7 January 2021

The role of phosphorylation/dephosphorylation in agonist-induced desensitization of D1 dopamine receptor function: evidence for a novel pathway for receptor dephosphorylation.

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEPH0301

7 January 2021

Relevance of dopamine signals anchoring dynamin-2 to the plasma membrane during Na+,K+-ATPase endocytosis

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEPH0301

7 January 2021

Renal protein phosphatase 2A activity and spontaneous hypertension in rats

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEPH0301

7 January 2021

Regulation of dopamine D-receptor activation in vivo by protein phosphatase 2B (calcineurin).

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEPH0301

7 January 2021

Phosphorylated Mr 32,000 dopamine- and cAMP-regulated phosphoprotein inhibits Na+,K(+)-ATPase activity in renal tubule cells

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEPH0301

7 January 2021

Amelioration of genetic hypertension by suppression of renal G protein-coupled receptor kinase type 4 expression

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEPH0301

7 January 2021

Association of G-protein-coupled receptor kinase 4 haplotypes, but not HSD3B1 or PTP1B polymorphisms, with essential hypertension

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEPH0301

7 January 2021

Association study with 33 single-nucleotide polymorphisms in 11 candidate genes for hypertension in Chinese

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEPH0301

7 January 2021

Single-nucleotide polymorphisms for diagnosis of salt-sensitive hypertension

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEPH0301

7 January 2021

Embryonic-endometrial interactions at implantation in humans

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEPH0301

7 January 2021

Identifiers

DOI

10.1038/NCPNEPH0301

1 reference

21 June 2017

1 reference