(Q30479173)

9 November 2017

Activation of trypsinogen in large endocytic vacuoles of pancreatic acinar cells (English)

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9 November 2017

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2

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9 November 2017

6

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9 November 2017

Mark W Sherwood

1

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9 November 2017

Svetlana G Voronina

3

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9 November 2017

Stephanie L Barrow

4

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9 November 2017

Jonathan D Woodsmith

5

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9 November 2017

Ole H Petersen

7

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9 November 2017

Alexei V Tepikin

8

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9 November 2017

language of work or name

English

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publication date

15 March 2007

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9 November 2017

6

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Proceedings of the National Academy of Sciences of the United States of America

inferred from page(s)

published in

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9 November 2017

104

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9 November 2017

13

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9 November 2017

5674-5679

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Co-localization hypothesis: a mechanism for the intrapancreatic activation of digestive enzymes during the early phases of acute pancreatitis

9 November 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1838486

Microdomains of intracellular Ca2+: molecular determinants and functional consequences.

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1838486

Zymogen activation in a reconstituted pancreatic acinar cell system

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1838486

The tetra-aspartate motif in the activation peptide of human cationic trypsinogen is essential for autoactivation control but not for enteropeptidase recognition

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1838486

Pathophysiology of acute pancreatitis

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1838486

Serine protease inhibitor kazal type 1 mutations and pancreatitis

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1838486

Vacuolar ATPase regulates zymogen activation in pancreatic acini

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1838486

Zymogen granule exocytosis is characterized by long fusion pore openings and preservation of vesicle lipid identity

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1838486

Human anionic trypsinogen: properties of autocatalytic activation and degradation and implications in pancreatic diseases

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1838486

Calcium-dependent enzyme activation and vacuole formation in the apical granular region of pancreatic acinar cells

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1838486

Role of cathepsin B in intracellular trypsinogen activation and the onset of acute pancreatitis

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1838486

The role of intracellular calcium signaling in premature protease activation and the onset of pancreatitis.

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1838486

Early trypsinogen activation in acute pancreatitis.

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1838486

Calcium uptake via endocytosis with rapid release from acidifying endosomes.

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1838486

Chloroquine stabilizes pancreatic lysosomes and improves survival of mice with diet-induced acute pancreatitis

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1838486

Use of glycyl-L-phenylalanine 2-naphthylamide, a lysosome-disrupting cathepsin C substrate, to distinguish between lysosomes and prelysosomal endocytic vacuoles

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1838486

Gallstones and acute pancreatitis--mechanisms and mechanics

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1838486

Luminal endocytosis and intracellular targeting by acinar cells during early biliary pancreatitis in the opossum

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1838486

Gallstone migration as a cause of acute pancreatitis.

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1838486

Intracellular vacuoles in experimental acute pancreatitis in rats and mice are an acidified compartment

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1838486

Stabilization of exocytosis by dynamic F-actin coating of zymogen granules in pancreatic acini

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1838486

Effects of secretagogues and bile acids on mitochondrial membrane potential of pancreatic acinar cells: comparison of different modes of evaluating DeltaPsim

26 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1838486

Ethanol differentially regulates NF-kappaB activation in pancreatic acinar cells through calcium and protein kinase C pathways

26 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1838486

Cathepsin B inhibition prevents trypsinogen activation and reduces pancreatitis severity

26 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1838486

Transporter-mediated bile acid uptake causes Ca2+-dependent cell death in rat pancreatic acinar cells

26 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1838486

Presence of cathepsin B in the human pancreatic secretory pathway and its role in trypsinogen activation during hereditary pancreatitis

26 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1838486

Trypsin activity is not involved in premature, intrapancreatic trypsinogen activation

26 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1838486

Comparative in vitro studies on native and recombinant human cationic trypsins. Cathepsin B is a possible pathological activator of trypsinogen in pancreatitis.

26 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1838486

Sequential-replenishment mechanism of exocytosis in pancreatic acini

26 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1838486

Influence of chloroquine on diet-induced pancreatitis.

26 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1838486

Ethanol sensitizes NF-kappaB activation in pancreatic acinar cells through effects on protein kinase C-epsilon

26 November 2018

1 reference

12 December 2020

Supramaximal caerulein stimulation and ultrastructure of rat pancreatic acinar cell: early morphological changes during development of experimental pancreatitis

1 reference

12 December 2020

Intracellular transport of pancreatic zymogens during caerulein supramaximal stimulation

1 reference

12 December 2020

Possible lysosomal activation of pancreatic zymogens. Activation of both human trypsinogens by cathepsin B and spontaneous acid. Activation of human trypsinogen 1

1 reference

12 December 2020

Direct detection of premature protease activation in living pancreatic acinar cells

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12 December 2020

Intra-acinar cell activation of trypsinogen during caerulein-induced pancreatitis in rats

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12 December 2020

Alcohol and the pancreas

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12 December 2020

Codistribution of TAP and the granule membrane protein GRAMP-92 in rat caerulein-induced pancreatitis

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12 December 2020

Zymogen proteolysis within the pancreatic acinar cell is associated with cellular injury

1 reference

12 December 2020

Secretagogue-induced digestive enzyme activation and cell injury in rat pancreatic acini

1 reference

12 December 2020

The activation of trypsinogen by cathepsin B

1 reference

12 December 2020

1 reference

12 December 2020

Identifiers

DOI

10.1073/PNAS.0700951104

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9 November 2017

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9 November 2017

PubMed publication ID

17363470

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