(Q30482681)

English

Calcium signaling in brain mitochondria: interplay of malate aspartate NADH shuttle and calcium uniporter/mitochondrial dehydrogenase pathways

scientific article

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scholarly article

1 reference

Europe PubMed Central

PMC publication ID

15 November 2017

Calcium signaling in brain mitochondria: interplay of malate aspartate NADH shuttle and calcium uniporter/mitochondrial dehydrogenase pathways (English)

1 reference

Europe PubMed Central

PMC publication ID

15 November 2017

1 reference

based on heuristic

inferred from title

Laura Contreras

1

1 reference

Europe PubMed Central

PMC publication ID

15 November 2017

author name string

Jorgina Satrústegui

2

1 reference

Europe PubMed Central

PMC publication ID

15 November 2017

language of work or name

0 references

publication date

7 January 2009

1 reference

Europe PubMed Central

PMC publication ID

15 November 2017

Journal of Biological Chemistry

1 reference

Europe PubMed Central

PMC publication ID

15 November 2017

284

1 reference

Europe PubMed Central

PMC publication ID

15 November 2017

11

1 reference

Europe PubMed Central

PMC publication ID

15 November 2017

7091-7099

1 reference

Europe PubMed Central

PMC publication ID

15 November 2017

Superoxide flashes in single mitochondria

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2652317

20 June 2018

Impaired regulation of brain mitochondria by extramitochondrial Ca2+ in transgenic Huntington disease rats

1 reference

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20 June 2018

A transcriptome database for astrocytes, neurons, and oligodendrocytes: a new resource for understanding brain development and function

1 reference

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20 June 2018

A quantitative proteomic analysis of mitochondrial participation in p19 cell neuronal differentiation.

1 reference

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20 June 2018

Cellular pathways of energy metabolism in the brain: is glucose used by neurons or astrocytes?

1 reference

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20 June 2018

Mitochondrial transporters as novel targets for intracellular calcium signaling.

1 reference

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20 June 2018

Ca2+ Activation kinetics of the two aspartate-glutamate mitochondrial carriers, aralar and citrin: role in the heart malate-aspartate NADH shuttle

1 reference

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20 June 2018

Sustained neuronal activation raises oxidative metabolism to a new steady-state level: evidence from 1H NMR spectroscopy in the human visual cortex

1 reference

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20 June 2018

Biphasic regulation of mitochondrial Ca2+ uptake by cytosolic Ca2+ concentration

1 reference

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20 June 2018

Brain work and brain imaging

1 reference

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20 June 2018

The mitochondrial permeability transition from in vitro artifact to disease target

1 reference

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20 June 2018

Neuronal and astrocytic shuttle mechanisms for cytosolic-mitochondrial transfer of reducing equivalents: current evidence and pharmacological tools

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2652317

20 June 2018

Calcium and mitochondria

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2652317

20 June 2018

Recombinant expression of the Ca(2+)-sensitive aspartate/glutamate carrier increases mitochondrial ATP production in agonist-stimulated Chinese hamster ovary cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2652317

20 June 2018

Developmental changes in the Ca2+-regulated mitochondrial aspartate-glutamate carrier aralar1 in brain and prominent expression in the spinal cord.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2652317

20 June 2018

Voltage-dependent anion channels control the release of the superoxide anion from mitochondria to cytosol.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2652317

20 June 2018

D-Lactate transport and metabolism in rat liver mitochondria

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2652317

20 June 2018

Calcium signaling: a tale for all seasons

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2652317

20 June 2018

Citrin and aralar1 are Ca(2+)-stimulated aspartate/glutamate transporters in mitochondria

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2652317

20 June 2018

Altered activities of rat brain metabolic enzymes in electroconvulsive shock-induced seizures

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2652317

20 June 2018

Energy on demand

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2652317

20 June 2018

From calcium signaling to cell death: two conformations for the mitochondrial permeability transition pore. Switching from low- to high-conductance state

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2652317

20 June 2018

Developmental regulation of the alpha-glycerophosphate shuttle in porcine myocardium.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2652317

20 June 2018

Mitochondria are excitable organelles capable of generating and conveying electrical and calcium signals.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2652317

20 June 2018

Calcium activation of mitochondrial glycerol phosphate dehydrogenase restudied

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2652317

20 June 2018

Towards the molecular basis for the regulation of mitochondrial dehydrogenases by calcium ions

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2652317

20 June 2018

Glutamate uptake into astrocytes stimulates aerobic glycolysis: a mechanism coupling neuronal activity to glucose utilization

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2652317

20 June 2018

Transport of calcium by mitochondria

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2652317

20 June 2018

Evidence for electrogenic aspartate transport in rat liver mitochondria

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2652317

20 June 2018

Characterization of shuttle mechanisms for the transport of reducing equivalents into mitochondria

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2652317

20 June 2018

Mechanism of the Exchanges Catalysed by the Oxoglutarate Translocator of Rat-Heart Mitochondria. Kinetics of the External-Product Inhibition

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2652317

20 June 2018

The role of ADP in the modulation of the calcium-efflux pathway in rat brain mitochondria

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2652317

20 June 2018

A new generation of Ca2+ indicators with greatly improved fluorescence properties

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2652317

20 June 2018

Nonoxidative glucose consumption during focal physiologic neural activity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2652317

20 June 2018

Regulation of citric acid cycle by calcium

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2652317

20 June 2018

Sequence of the bovine 2-oxoglutarate/malate carrier protein: structural relationship to other mitochondrial transport proteins

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2652317

20 June 2018

Mechanisms by which mitochondria transport calcium

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2652317

20 June 2018

Role of calcium ions in regulation of mammalian intramitochondrial metabolism

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2652317

20 June 2018

Regulation of cytosolic free calcium concentration by intrasynaptic mitochondria

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2652317

20 June 2018

Regulation of mitochondrial glycerol-phosphate dehydrogenase by Ca2+ within electropermeabilized insulin-secreting cells (INS-1)

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2652317

20 June 2018

Calcium transport and proton electrochemical potential gradient in mitochondria from guinea-pig cerebral cortex and rat heart

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2652317

20 June 2018

Reconstruction of the α-glycerolphosphate shuttle using rat kidney mitochondria

1 reference

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20 June 2018

The effects of calcium ions and adenine nucleotides on the activity of pig heart 2-oxoglutarate dehydrogenase complex

1 reference

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20 June 2018

Essential role of aralar in the transduction of small Ca2+ signals to neuronal mitochondria.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M808066200

21 January 2018

Expression of three mitochondrial solute carriers, citrin, aralar1 and ornithine transporter, in relation to urea cycle in mice.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M808066200

21 January 2018

Expression of the aspartate/glutamate mitochondrial carriers aralar1 and citrin during development and in adult rat tissues.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M808066200

21 January 2018

Functional imaging of focal brain activation in conscious rats: impact of [(14)C]glucose metabolite spreading and release

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M808066200

21 January 2018

Generalized sensory stimulation of conscious rats increases labeling of oxidative pathways of glucose metabolism when the brain glucose-oxygen uptake ratio rises

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M808066200

21 January 2018

Reduced N-acetylaspartate levels in mice lacking aralar, a brain- and muscle-type mitochondrial aspartate-glutamate carrier

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M808066200

21 January 2018

Glutamate neurotoxicity in rat cerebellar granule cells involves cytochrome c release from mitochondria and mitochondrial shuttle impairment

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M808066200

21 January 2018

Influence of the Malate-Aspartate Shuttle on Oxidative Metabolism in Synaptosomes

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M808066200

21 January 2018

Mitochondrial alpha-ketoglutarate dehydrogenase complex generates reactive oxygen species.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M808066200

21 January 2018

The relationship between free and total calcium concentrations in the matrix of liver and brain mitochondria.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M808066200

21 January 2018

Species- and tissue-specific relationships between mitochondrial permeability transition and generation of ROS in brain and liver mitochondria of rats and mice.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M808066200

21 January 2018

Stimulation of alpha1-adrenoceptors in the rat medial prefrontal cortex increases the local in vivo 5-hydroxytryptamine release: reversal by antipsychotic drugs.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M808066200

21 January 2018

In situ fluorescence imaging of glutamate-evoked mitochondrial Na+ responses in astrocytes.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M808066200

21 January 2018

The regulation of brain mitochondrial calcium-ion transport. The role of ATP in the discrimination between kinetic and membrane-potential-dependent calcium-ion efflux mechanisms

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M808066200

21 January 2018

Requirement for aralar and its Ca2+-binding sites in Ca2+ signal transduction in mitochondria from INS-1 clonal beta-cells.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M808066200

21 January 2018

Deletion of glutamate dehydrogenase in beta-cells abolishes part of the insulin secretory response not required for glucose homeostasis.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M808066200

21 January 2018

Regulatory effects of 5'-deoxypyridoxal on glutamate dehydrogenase activity and insulin secretion in pancreatic islets

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M808066200

21 January 2018

Neural activity triggers neuronal oxidative metabolism followed by astrocytic glycolysis.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M808066200

21 January 2018

Glutamate receptor-dependent increments in lactate, glucose and oxygen metabolism evoked in rat cerebellum in vivo.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M808066200

21 January 2018

Metabolism of [1,6-(13)C]glucose and [U-(13)C]glutamine and depolarization induced GABA release in superfused mouse cerebral cortical mini-slices.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M808066200

21 January 2018

Glucose is necessary to maintain neurotransmitter homeostasis during synaptic activity in cultured glutamatergic neurons

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M808066200

21 January 2018

Cerebral pyruvate carboxylase flux is unaltered during bicuculline-seizures

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M808066200

21 January 2018

A gated pathway for electrophoretic Na+ fluxes in rat liver mitochondria. Regulation by surface Mg2+

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M808066200

21 January 2018

A new pathway for lactate production in the CNS.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2652317

26 November 2018

Limited transfer of cytosolic NADH into mitochondria at high cardiac workload

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2652317

26 November 2018

Neuronal uptake and metabolism of glycerol and the neuronal expression of mitochondrial glycerol‐3‐phosphate dehydrogenase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2652317

26 November 2018

Inhibition of Krebs cycle enzymes by hydrogen peroxide: A key role of [alpha]-ketoglutarate dehydrogenase in limiting NADH production under oxidative stress.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2652317

26 November 2018

Cerebral oxygen/glucose ratio is low during sensory stimulation and rises above normal during recovery: excess glucose consumption during stimulation is not accounted for by lactate efflux from or accumulation in brain tissue

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2652317

26 November 2018

Energy sources for glutamate neurotransmission in the retina: absence of the aspartate/glutamate carrier produces reliance on glycolysis in glia

1 reference

https://pubmed.ncbi.nlm.nih.gov/19129175

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mitochondrial transport proteins of the brain

1 reference

https://pubmed.ncbi.nlm.nih.gov/19129175

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The transcriptome and metabolic gene signature of protoplasmic astrocytes in the adult murine cortex

1 reference

https://pubmed.ncbi.nlm.nih.gov/19129175

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Characteristics of mitochondrial proton leak and control of oxidative phosphorylation in the major oxygen-consuming tissues of the rat

1 reference

https://pubmed.ncbi.nlm.nih.gov/19129175

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Lactate released by Müller glial cells is metabolized by photoreceptors from mammalian retina

1 reference

https://pubmed.ncbi.nlm.nih.gov/19129175

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Reducing equivalent shuttles in developing porcine myocardium: enhanced capacity in the newborn heart

1 reference

https://pubmed.ncbi.nlm.nih.gov/19129175

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Dehydrogenase regulation of metabolite oxidation and efflux from mitochondria in intact hearts

1 reference

https://pubmed.ncbi.nlm.nih.gov/19129175

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Energy-driven aspartate efflux from heart and liver mitochondria

1 reference

https://pubmed.ncbi.nlm.nih.gov/19129175

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Electrogenic characteristics of the mitochondrial glutamate-aspartate antiporter

1 reference

https://pubmed.ncbi.nlm.nih.gov/19129175

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Immunocytochemical localization of glycerol-3-phosphate dehydrogenase in rat oligodendrocytes

1 reference

https://pubmed.ncbi.nlm.nih.gov/19129175

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Ca2+ stimulation of rat liver mitochondrial glycerophosphate dehydrogenase

1 reference

https://pubmed.ncbi.nlm.nih.gov/19129175

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cytosolic free calcium levels increase with age in rat brain synaptosomes

1 reference

https://pubmed.ncbi.nlm.nih.gov/19129175

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Affinity chromatography purification of mitochondrial inner membrane proteins with calcium transport activity

1 reference

https://pubmed.ncbi.nlm.nih.gov/19129175

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Heterogeneity of mitochondrial matrix free ca2+: resolution of Ca2+ dynamics in individual mitochondria in situ

1 reference

https://pubmed.ncbi.nlm.nih.gov/19129175

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The mitochondrial Na+/Ca2+ exchanger plays a key role in the control of cytosolic Ca2+ oscillations

1 reference

https://pubmed.ncbi.nlm.nih.gov/19129175

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1074/JBC.M808066200

1 reference

Europe PubMed Central

PMC publication ID

15 November 2017

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

15 November 2017

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

15 November 2017

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