(Q30491532)

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Homozygous missense N629D hERG (KCNH2) potassium channel mutation causes developmental defects in the right ventricle and its outflow tract and embryonic lethality.

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25 December 2019

Homozygous missense N629D hERG (KCNH2) potassium channel mutation causes developmental defects in the right ventricle and its outflow tract and embryonic lethality (English)

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25 December 2019

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25 December 2019

8

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25 December 2019

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25 December 2019

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Guo Qi Teng

1

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25 December 2019

Xian Zhao

2

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25 December 2019

James P Lees-Miller

3

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25 December 2019

F Russell Quinn

4

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25 December 2019

Pin Li

5

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25 December 2019

Derrick E Rancourt

6

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25 December 2019

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23 October 2008

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25 December 2019

Circulation Research

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25 December 2019

103

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25 December 2019

12

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25 December 2019

1483-1491

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25 December 2019

Doxazosin induces apoptosis of cells expressing hERG K+ channels.

1 reference

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Smad4 is required to regulate the fate of cranial neural crest cells

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Expression and significance of HERG protein in gastric cancer

1 reference

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Mesoderm progenitor cells of common origin contribute to the head musculature and the cardiac outflow tract

1 reference

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A case of long QT syndrome associated with familial occurrence of persistent patency of the arterial duct

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Applications for multifrequency ultrasound biomicroscopy in mice from implantation to adulthood.

1 reference

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20 June 2018

Role of glycosylation in cell surface expression and stability of HERG potassium channels

1 reference

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20 June 2018

Class III antiarrhythmics and phenytoin: teratogenicity due to embryonic cardiac dysrhythmia and reoxygenation damage

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Developmental toxicity in the pregnant rabbit by the class III antiarrhythmic drug sotalol

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Genotype and severity of long QT syndrome

1 reference

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20 June 2018

Inherited long QT syndromes: a paradigm for understanding arrhythmogenesis

1 reference

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20 June 2018

A variant of long QT syndrome manifested as fetal tachycardia and associated with ventricular septal defect

1 reference

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20 June 2018

Teratogenicity of the class III antiarrhythmic drug almokalant. Role of hypoxia and reactive oxygen species

1 reference

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20 June 2018

A signaling cascade involving endothelin-1, dHAND and msx1 regulates development of neural-crest-derived branchial arch mesenchyme

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2774899

20 June 2018

Multiple different missense mutations in the pore region of HERG in patients with long QT syndrome

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2774899

20 June 2018

HERG- and IRK-like inward rectifier currents are sequentially expressed during neuronal development of neural crest cells and their derivatives

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2774899

20 June 2018

Two isoforms of the mouse ether-a-go-go-related gene coassemble to form channels with properties similar to the rapidly activating component of the cardiac delayed rectifier K+ current

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2774899

20 June 2018

Regulation of cardiac mesodermal and neural crest development by the bHLH transcription factor, dHAND

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2774899

20 June 2018

Developmental changes in the delayed rectifier K+ channels in mouse heart.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2774899

20 June 2018

Hxt encodes a basic helix-loop-helix transcription factor that regulates trophoblast cell development

1 reference

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20 June 2018

Exogenous retinoic acid rapidly induces anterior ectopic expression of murine Hox-2 genes in vivo

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2774899

20 June 2018

Ca2+ influx-induced sarcoplasmic reticulum Ca2+ overload causes mitochondrial-dependent apoptosis in ventricular myocytes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2774899

26 November 2018

Post-hoc diagnosis of congenital long QT syndrome in patients with tetralogy of Fallot

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2774899

26 November 2018

Mutations in the HERG K+-ion channel: A novel link between long QT syndrome and sudden infant death syndrome

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2774899

26 November 2018

[K(+)](o)-dependent change in conformation of the HERG1 long QT mutation N629D channel results in partial reversal of the in vitro disease phenotype

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2774899

26 November 2018

Novel gain-of-function mechanism in K(+) channel-related long-QT syndrome: altered gating and selectivity in the HERG1 N629D mutant

1 reference

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Homozygous premature truncation of the HERG protein : the human HERG knockout

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2774899

26 November 2018

[Autosomal dominant Mendelian midline complex. Secundum atrial septal defect associated with cardiac and facial-thoracic defects. A familial case]

1 reference

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12 December 2020

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inferred from PubMed ID database lookup

Divergent expression of delayed rectifier K+ channel subunits during mouse heart development

1 reference

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inferred from PubMed ID database lookup

Molecular biology and cellular mechanisms of Brugada and long QT syndromes in infants and young children

1 reference

https://pubmed.ncbi.nlm.nih.gov/18948620

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inferred from PubMed ID database lookup

Prolonged repolarization and triggered activity induced by adenoviral expression of HERG N629D in cardiomyocytes derived from stem cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/18948620

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inferred from PubMed ID database lookup

Loss of Apaf-1 leads to partial rescue of the HAND2-null phenotype

1 reference

https://pubmed.ncbi.nlm.nih.gov/18948620

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Polytherapy with hERG-blocking antiepileptic drugs: increased risk for embryonic cardiac arrhythmia and teratogenicity

1 reference

https://pubmed.ncbi.nlm.nih.gov/18948620

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inferred from PubMed ID database lookup

An intrinsic timer that controls cell-cycle withdrawal in cultured cardiac myocytes

1 reference

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inferred from PubMed ID database lookup

Identifiers

10.1161/CIRCRESAHA.108.177055

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18948620%20AND%20SRC:MED&resulttype=core&format=json

25 December 2019

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18948620%20AND%20SRC:MED&resulttype=core&format=json

25 December 2019

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18948620%20AND%20SRC:MED&resulttype=core&format=json

25 December 2019

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