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The actin-bundling protein palladin is an Akt1-specific substrate that regulates breast cancer cell migration
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scholarly article
1 reference
stated in
Europe PubMed Central
PMC publication ID
2872630
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20471940%20AND%20SRC:MED&resulttype=core&format=json
retrieved
2 February 2020
title
The actin-bundling protein palladin is an Akt1-specific substrate that regulates breast cancer cell migration
(English)
1 reference
stated in
Europe PubMed Central
PMC publication ID
2872630
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20471940%20AND%20SRC:MED&resulttype=core&format=json
retrieved
2 February 2020
main subject
breast cancer
1 reference
based on heuristic
inferred from title
cell migration
1 reference
based on heuristic
inferred from title
author
Yuet Ming Rebecca Chin
series ordinal
1
1 reference
stated in
Europe PubMed Central
PMC publication ID
2872630
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20471940%20AND%20SRC:MED&resulttype=core&format=json
retrieved
2 February 2020
author name string
Alex Toker
series ordinal
2
1 reference
stated in
Europe PubMed Central
PMC publication ID
2872630
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20471940%20AND%20SRC:MED&resulttype=core&format=json
retrieved
2 February 2020
publication date
1 May 2010
1 reference
stated in
Europe PubMed Central
PMC publication ID
2872630
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20471940%20AND%20SRC:MED&resulttype=core&format=json
retrieved
2 February 2020
published in
Molecular Cell
1 reference
stated in
Europe PubMed Central
PMC publication ID
2872630
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20471940%20AND%20SRC:MED&resulttype=core&format=json
retrieved
2 February 2020
volume
38
1 reference
stated in
Europe PubMed Central
PMC publication ID
2872630
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20471940%20AND%20SRC:MED&resulttype=core&format=json
retrieved
2 February 2020
issue
3
1 reference
stated in
Europe PubMed Central
PMC publication ID
2872630
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20471940%20AND%20SRC:MED&resulttype=core&format=json
retrieved
2 February 2020
page(s)
333-344
1 reference
stated in
Europe PubMed Central
PMC publication ID
2872630
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20471940%20AND%20SRC:MED&resulttype=core&format=json
retrieved
2 February 2020
cites work
Differential enhancement of breast cancer cell motility and metastasis by helical and kinase domain mutations of class IA phosphoinositide 3-kinase
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2872630
retrieved
14 July 2018
Insulin-modulated Akt subcellular localization determines Akt isoform-specific signaling
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2872630
retrieved
14 July 2018
Phosphorylation by Akt1 promotes cytoplasmic localization of Skp2 and impairs APCCdh1-mediated Skp2 destruction
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2872630
retrieved
14 July 2018
Integrins in cell migration--the actin connection
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2872630
retrieved
14 July 2018
Function of Akt/PKB signaling to cell motility, invasion and the tumor stroma in cancer.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2872630
retrieved
14 July 2018
Palladin contributes to invasive motility in human breast cancer cells
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2872630
retrieved
14 July 2018
mTOR-raptor binds and activates SGK1 to regulate p27 phosphorylation
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2872630
retrieved
14 July 2018
Comprehensive analysis of oncogenic effects of PIK3CA mutations in human mammary epithelial cells
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2872630
retrieved
14 July 2018
Palladin interacts with SH3 domains of SPIN90 and Src and is required for Src-induced cytoskeletal remodeling
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2872630
retrieved
14 July 2018
PHLPP and a second isoform, PHLPP2, differentially attenuate the amplitude of Akt signaling by regulating distinct Akt isoforms
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2872630
retrieved
14 July 2018
Polymerizing actin fibers position integrins primed to probe for adhesion sites
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2872630
retrieved
14 July 2018
Large-scale phosphorylation analysis of mouse liver
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2872630
retrieved
14 July 2018
Global, in vivo, and site-specific phosphorylation dynamics in signaling networks
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2872630
retrieved
14 July 2018
Only Akt1 is required for proliferation, while Akt2 promotes cell cycle exit through p21 binding.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2872630
retrieved
14 July 2018
Palladin binds to Eps8 and enhances the formation of dorsal ruffles and podosomes in vascular smooth muscle cells
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2872630
retrieved
14 July 2018
The evolution of phosphatidylinositol 3-kinases as regulators of growth and metabolism
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2872630
retrieved
14 July 2018
siRNA-based gene silencing reveals specialized roles of IRS-1/Akt2 and IRS-2/Akt1 in glucose and lipid metabolism in human skeletal muscle
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2872630
retrieved
14 July 2018
Mechanism of Akt1 inhibition of breast cancer cell invasion reveals a protumorigenic role for TSC2.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2872630
retrieved
14 July 2018
The proline-rich protein palladin is a binding partner for profilin
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2872630
retrieved
14 July 2018
Distinct roles of Akt1 and Akt2 in regulating cell migration and epithelial-mesenchymal transition
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2872630
retrieved
14 July 2018
Exploiting the PI3K/AKT pathway for cancer drug discovery
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2872630
retrieved
14 July 2018
Akt blocks breast cancer cell motility and invasion through the transcription factor NFAT
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2872630
retrieved
14 July 2018
Perturbations of the AKT signaling pathway in human cancer
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2872630
retrieved
14 July 2018
PIK3CA mutations correlate with hormone receptors, node metastasis, and ERBB2, and are mutually exclusive with PTEN loss in human breast carcinoma
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2872630
retrieved
14 July 2018
Recent advances in the protein kinase B signaling pathway
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2872630
retrieved
14 July 2018
Molecular analysis of the interaction between palladin and alpha-actinin
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2872630
retrieved
14 July 2018
Morphogenesis and oncogenesis of MCF-10A mammary epithelial acini grown in three-dimensional basement membrane cultures
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2872630
retrieved
14 July 2018
Overexpression of AKT2/protein kinase Bbeta leads to up-regulation of beta1 integrins, increased invasion, and metastasis of human breast and ovarian cancer cells
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2872630
retrieved
14 July 2018
Characterization of human palladin, a microfilament-associated protein
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2872630
retrieved
14 July 2018
AKT-1, -2, and -3 are expressed in both normal and tumor tissues of the lung, breast, prostate, and colon.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2872630
retrieved
14 July 2018
Peptide and protein library screening defines optimal substrate motifs for AKT/PKB.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2872630
retrieved
14 July 2018
Characterization of palladin, a novel protein localized to stress fibers and cell adhesions
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2872630
retrieved
14 July 2018
Differential regulation of glycogen synthase kinase 3beta by insulin and Wnt signaling
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2872630
retrieved
14 July 2018
ECM degradation assays for analyzing local cell invasion.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2872630
retrieved
26 November 2018
Akt1 ablation inhibits, whereas Akt2 ablation accelerates, the development of mammary adenocarcinomas in mouse mammary tumor virus (MMTV)-ErbB2/neu and MMTV-polyoma middle T transgenic mice
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2872630
retrieved
26 November 2018
Palladin regulates cell and extracellular matrix interaction through maintaining normal actin cytoskeleton architecture and stabilizing beta1-integrin.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2872630
retrieved
26 November 2018
Will kinase inhibitors have a dark side?
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2872630
retrieved
26 November 2018
Tumor cell sensitization to apoptotic stimuli by selective inhibition of specific Akt/PKB family members
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2872630
retrieved
26 November 2018
Identification and testing of a gene expression signature of invasive carcinoma cells within primary mammary tumors.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2872630
retrieved
26 November 2018
Activation of Akt-1 (PKB-alpha) can accelerate ErbB-2-mediated mammary tumorigenesis but suppresses tumor invasion
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2872630
retrieved
26 November 2018
Palladin is a novel binding partner for Ena/VASP family members.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2872630
retrieved
26 November 2018
Opposing Roles for Akt1 and Akt2 in Rac/Pak Signaling and Cell Migration
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/20471940
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Palladin is an actin cross-linking protein that uses immunoglobulin-like domains to bind filamentous actin
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/20471940
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Identifiers
DOI
10.1016/J.MOLCEL.2010.02.031
1 reference
stated in
Europe PubMed Central
PMC publication ID
2872630
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20471940%20AND%20SRC:MED&resulttype=core&format=json
retrieved
2 February 2020
PMC publication ID
2872630
1 reference
stated in
Europe PubMed Central
PMC publication ID
2872630
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20471940%20AND%20SRC:MED&resulttype=core&format=json
retrieved
2 February 2020
PubMed publication ID
20471940
1 reference
stated in
Europe PubMed Central
PMC publication ID
2872630
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20471940%20AND%20SRC:MED&resulttype=core&format=json
retrieved
2 February 2020
ResearchGate publication ID
44601164
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