(Q30512752)

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Regulator of G protein signaling 2 deficiency causes endothelial dysfunction and impaired endothelium-derived hyperpolarizing factor-mediated relaxation by dysregulating Gi/o signaling

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23 January 2020

Regulator of G protein signaling 2 deficiency causes endothelial dysfunction and impaired endothelium-derived hyperpolarizing factor-mediated relaxation by dysregulating Gi/o signaling (English)

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23 January 2020

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Rasna Sabharwal

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23 January 2020

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23 January 2020

Mark W Chapleau

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23 January 2020

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Patrick Osei-Owusu

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23 January 2020

Kevin M Kaltenbronn

3

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23 January 2020

Hans H Dietrich

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23 January 2020

Kendall J Blumer

7

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23 January 2020

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21 February 2012

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23 January 2020

Journal of Biological Chemistry

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23 January 2020

287

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23 January 2020

15

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23 January 2020

12541-12549

1 reference

Europe PubMed Central

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23 January 2020

Promoter Polymorphism of RGS2 Gene Is Associated with Change of Blood Pressure in Subjects with Antihypertensive Treatment: The Azelnidipine and Temocapril in Hypertensive Patients with Type 2 Diabetes Study

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3321003

20 June 2018

Renal actions of RGS2 control blood pressure

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3321003

20 June 2018

Endothelium-derived vasoactive factors and hypertension: possible roles in pathogenesis and as treatment targets

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3321003

20 June 2018

Endothelium-derived hyperpolarising factors and associated pathways: a synopsis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3321003

20 June 2018

Genetic ablation of calcium-independent phospholipase A(2)beta causes hypercontractility and markedly attenuates endothelium-dependent relaxation to acetylcholine

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3321003

20 June 2018

Receptor activity-modifying protein 1 increases baroreflex sensitivity and attenuates Angiotensin-induced hypertension.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3321003

20 June 2018

Cellular signaling and NO production

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3321003

20 June 2018

Accumulation of common polymorphisms is associated with development of hypertension: a 12-year follow-up from the Ohasama study.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3321003

20 June 2018

Structural Determinants of G-protein Subunit Selectivity by Regulator of G-protein Signaling 2 (RGS2)

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3321003

20 June 2018

RGS proteins: identifying new GAPs in the understanding of blood pressure regulation and cardiovascular function

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3321003

20 June 2018

Endothelium-derived hyperpolarizing factor mediated relaxations in pig coronary arteries do not involve Gi/o proteins

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3321003

20 June 2018

Hypertension and the absence of EDHF-mediated responses favour endothelium-dependent contractions in renal arteries of the rat.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3321003

20 June 2018

The RGS2 gene product from a candidate hypertension allele shows decreased plasma membrane association and inhibition of Gq.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3321003

20 June 2018

G12-G13-LARG-mediated signaling in vascular smooth muscle is required for salt-induced hypertension

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3321003

20 June 2018

N-terminal residues control proteasomal degradation of RGS2, RGS4, and RGS5 in human embryonic kidney 293 cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3321003

20 June 2018

How regulators of G protein signaling achieve selective regulation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3321003

20 June 2018

Cellular mechanisms that determine selective RGS protein regulation of G protein-coupled receptor signaling

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3321003

20 June 2018

RGS proteins have a signalling complex: interactions between RGS proteins and GPCRs, effectors, and auxiliary proteins

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3321003

20 June 2018

Genetic variations of regulator of G-protein signaling 2 in hypertensive patients and in the general population

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3321003

20 June 2018

Regulator of G-protein signaling-2 mediates vascular smooth muscle relaxation and blood pressure

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3321003

20 June 2018

Comparison of P 2 Receptor Subtypes Producing Dilation in Rat Intracerebral Arterioles

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3321003

20 June 2018

Hypertension and prolonged vasoconstrictor signaling in RGS2-deficient mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3321003

20 June 2018

EDHF: bringing the concepts together

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3321003

20 June 2018

cAMP facilitates EDHF-type relaxations in conduit arteries by enhancing electrotonic conduction via gap junctions.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3321003

20 June 2018

Regulation of T cell activation, anxiety, and male aggression by RGS2.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3321003

20 June 2018

G protein selectivity is a determinant of RGS2 function.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3321003

20 June 2018

The generation of nitric oxide by G protein-coupled receptors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3321003

20 June 2018

Dynamic regulation of RGS2 suggests a novel mechanism in G-protein signaling and neuronal plasticity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3321003

20 June 2018

A comparison of EDHF-mediated and anandamide-induced relaxations in the rat isolated mesenteric artery.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3321003

20 June 2018

RGS2/G0S8 is a selective inhibitor of Gqalpha function

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3321003

20 June 2018

Insulin enhances endothelial alpha2-adrenergic vasorelaxation by a pertussis toxin mechanism

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3321003

20 June 2018

G proteins and endothelium-dependent relaxations

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3321003

20 June 2018

Pharmacology of pertussis toxin B-oligomer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3321003

20 June 2018

Stimulation of alpha 2 adrenoceptors dilates the rat middle cerebral artery

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3321003

20 June 2018

Intracellular calcium, currents, and stimulus-response coupling in endothelial cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3321003

20 June 2018

Pertussis toxin inhibits endothelium-dependent relaxations to certain agonists in porcine coronary arteries.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3321003

20 June 2018

Natural course of the impairment of endothelium-dependent relaxations after balloon endothelium removal in porcine coronary arteries. Possible dysfunction of a pertussis toxin-sensitive G protein

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3321003

20 June 2018

Endothelium-dependent and BRL 34915-induced vasodilatation in rat isolated perfused mesenteric arteries: role of G-proteins, K+ and calcium channels

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3321003

20 June 2018

Pertussis toxin inhibits contractions but not endothelium-dependent relaxations of rabbit pulmonary artery in response to acetylcholine and other agonists

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3321003

20 June 2018

Loss of endothelial pertussis toxin-sensitive G protein function in atherosclerotic porcine coronary arteries

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3321003

20 June 2018

Endothelial dysfunction

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M111.332130

21 January 2018

Genetic deficit of SK3 and IK1 channels disrupts the endothelium-derived hyperpolarizing factor vasodilator pathway and causes hypertension

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M111.332130

21 January 2018

Polymorphisms and haplotypes of the regulator of G protein signaling-2 gene in normotensives and hypertensives.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M111.332130

21 January 2018

Fine tuning of blood pressure by the regulator of G protein signaling (RGS) 2.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M111.332130

21 January 2018

Association of genetic variations of regulator of G-protein signaling 2 with hypertension in the general Xinjiang Kazakh population

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M111.332130

21 January 2018

RGS2 expression and aldosterone: renin ratio modulate response to drug therapy in hypertensive patients.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M111.332130

21 January 2018

Regulator of G protein signalling 2 ameliorates angiotensin II-induced hypertension in mice

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M111.332130

21 January 2018

Sympathetic nerve traffic and circulating norepinephrine levels in RGS2-deficient mice.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M111.332130

21 January 2018

RGS2 is a mediator of nitric oxide action on blood pressure and vasoconstrictor signaling.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M111.332130

21 January 2018

Temporal Cre-mediated recombination exclusively in endothelial cells using Tie2 regulatory elements

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M111.332130

21 January 2018

Autonomic nervous system and blood pressure regulation in RGS2-deficient mice

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M111.332130

21 January 2018

Alterations in EDHF-type relaxation and phosphodiesterase activity in mesenteric arteries from diabetic rats

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M111.332130

21 January 2018

Porcine coronary arteries with regenerated endothelium have a reduced endothelium-dependent responsiveness to aggregating platelets and serotonin

1 reference

https://pubmed.ncbi.nlm.nih.gov/22354966

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Coupling of muscarinic m1, m2 and m3 acetylcholine receptors, expressed in Chinese hamster ovary cells, to pertussis toxin-sensitive/insensitive guanine nucleotide-binding proteins

1 reference

https://pubmed.ncbi.nlm.nih.gov/22354966

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mechanisms underlying the impaired EDHF-type relaxation response in mesenteric arteries from Otsuka Long-Evans Tokushima Fatty (OLETF) rats

1 reference

https://pubmed.ncbi.nlm.nih.gov/22354966

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Calcium-activated potassium channel and connexin expression in small mesenteric arteries from eNOS-deficient (eNOS-/-) and eNOS-expressing (eNOS+/+) mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/22354966

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inhibition of endothelium-dependent relaxations by phorbol myristate acetate in canine coronary arteries: role of a pertussis toxin-sensitive G-protein

1 reference

https://pubmed.ncbi.nlm.nih.gov/22354966

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

RGS proteins: Swiss army knives in seven-transmembrane domain receptor signaling networks

1 reference

https://pubmed.ncbi.nlm.nih.gov/22354966

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Pertussis toxin reduces endothelium-dependent and independent responses to alpha-2- adrenergic stimulation in systemic canine arteries and veins

1 reference

https://pubmed.ncbi.nlm.nih.gov/22354966

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Vanadate causes synthesis of endothelium-derived NO via pertussis toxin-sensitive G protein in pigs

1 reference

https://pubmed.ncbi.nlm.nih.gov/22354966

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The role of Gi proteins in reduced vasorelaxation response to beta-adrenoceptor agonists in rat aorta during maturation

1 reference

https://pubmed.ncbi.nlm.nih.gov/22354966

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1074/JBC.M111.332130

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22354966%20AND%20SRC:MED&resulttype=core&format=json

23 January 2020

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22354966%20AND%20SRC:MED&resulttype=core&format=json

23 January 2020

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22354966%20AND%20SRC:MED&resulttype=core&format=json

23 January 2020

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