(Q30514021)

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Advances in establishment and analysis of three-dimensional tumor spheroid-based functional assays for target validation and drug evaluation

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scholarly article

1 reference

Europe PubMed Central

PMC publication ID

11 August 2017

Advances in establishment and analysis of three-dimensional tumor spheroid-based functional assays for target validation and drug evaluation (English)

1 reference

Europe PubMed Central

PMC publication ID

11 August 2017

1 reference

ORCID Public Data File 2021

author name string

Maria Vinci

1

1 reference

Europe PubMed Central

PMC publication ID

11 August 2017

Sharon Gowan

2

1 reference

Europe PubMed Central

PMC publication ID

11 August 2017

Frances Boxall

3

1 reference

Europe PubMed Central

PMC publication ID

11 August 2017

Lisa Patterson

4

1 reference

Europe PubMed Central

PMC publication ID

11 August 2017

Miriam Zimmermann

5

1 reference

Europe PubMed Central

PMC publication ID

11 August 2017

William Court

6

1 reference

Europe PubMed Central

PMC publication ID

11 August 2017

Cara Lomas

7

1 reference

Europe PubMed Central

PMC publication ID

11 August 2017

Marta Mendiola

8

1 reference

Europe PubMed Central

PMC publication ID

11 August 2017

David Hardisson

9

1 reference

Europe PubMed Central

PMC publication ID

11 August 2017

Suzanne A Eccles

10

1 reference

Europe PubMed Central

PMC publication ID

11 August 2017

publication date

22 March 2012

1 reference

Europe PubMed Central

PMC publication ID

11 August 2017

1 reference

Europe PubMed Central

PMC publication ID

11 August 2017

10

1 reference

Europe PubMed Central

PMC publication ID

11 August 2017

29

1 reference

Europe PubMed Central

PMC publication ID

11 August 2017

Glioma cell migration on three-dimensional nanofiber scaffolds is regulated by substrate topography and abolished by inhibition of STAT3 signaling.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3349530

20 June 2018

The development and characterization of a human mesothelioma in vitro 3D model to investigate immunotoxin therapy

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3349530

20 June 2018

3D models of epithelial-mesenchymal transition in breast cancer metastasis: high-throughput screening assay development, validation, and pilot screen

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3349530

20 June 2018

Morphological and cytoskeletal changes of pancreatic cancer cells in three-dimensional spheroidal culture

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3349530

20 June 2018

3D cell culture: a review of current approaches and techniques

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3349530

20 June 2018

The plasticity of cytoskeletal dynamics underlying neoplastic cell migration

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3349530

20 June 2018

Secretion of extracellular hsp90alpha via exosomes increases cancer cell motility: a role for plasminogen activation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3349530

20 June 2018

A comprehensive panel of three-dimensional models for studies of prostate cancer growth, invasion and drug responses

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3349530

20 June 2018

In situ protein expression in tumour spheres: development of an immunostaining protocol for confocal microscopy

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3349530

20 June 2018

Multicellular tumor spheroids: an underestimated tool is catching up again.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3349530

20 June 2018

Mechanisms of collective cell migration at a glance

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3349530

20 June 2018

Collective cell migration

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3349530

20 June 2018

Identification of gastric cancer stem cells using the cell surface marker CD44.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3349530

20 June 2018

Molecular and phenotypic characterisation of paediatric glioma cell lines as models for preclinical drug development

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3349530

20 June 2018

Spheroid-based drug screen: considerations and practical approach

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3349530

20 June 2018

Aurora kinases as prognostic biomarkers in ovarian carcinoma.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3349530

20 June 2018

Modelling tissues in 3D: the next future of pharmaco-toxicology and food research?

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3349530

20 June 2018

Invadopodia: at the cutting edge of tumour invasion.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3349530

20 June 2018

Brca1 breast tumors contain distinct CD44+/CD24- and CD133+ cells with cancer stem cell characteristics

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3349530

20 June 2018

Experimental anti-tumor therapy in 3-D: spheroids--old hat or new challenge?

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3349530

20 June 2018

Blocking heat shock protein-90 inhibits the invasive properties and hepatic growth of human colon cancer cells and improves the efficacy of oxaliplatin in p53-deficient colon cancer tumors in vivo

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3349530

20 June 2018

Diversity of cell-mediated adhesions in breast cancer spheroids.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3349530

20 June 2018

Engineering tumors with 3D scaffolds

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3349530

20 June 2018

The phosphatidylinositol 3-kinase inhibitor, PX-866, is a potent inhibitor of cancer cell motility and growth in three-dimensional cultures

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3349530

20 June 2018

The third dimension bridges the gap between cell culture and live tissue

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3349530

20 June 2018

Three-dimensional culture models of normal and malignant breast epithelial cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3349530

20 June 2018

The history of the angiogenic switch concept

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3349530

20 June 2018

Rapid generation of single-tumor spheroids for high-throughput cell function and toxicity analysis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3349530

20 June 2018

Drug penetration in solid tumours

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3349530

20 June 2018

Dominant-negative inhibition of the Axl receptor tyrosine kinase suppresses brain tumor cell growth and invasion and prolongs survival

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3349530

20 June 2018

Invadopodia: a guided tour.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3349530

20 June 2018

A microscale in vitro physiological model of the liver: predictive screens for drug metabolism and enzyme induction

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3349530

20 June 2018

The use of 3-D cultures for high-throughput screening: the multicellular spheroid model

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3349530

20 June 2018

Spheroid preparation from hanging drops: characterization of a model of brain tumor invasion.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3349530

20 June 2018

Three-dimensional in vitro tissue culture models of breast cancer-- a review.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3349530

20 June 2018

Prespecification and plasticity: shifting mechanisms of cell migration

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3349530

20 June 2018

Identification of a cancer stem cell in human brain tumors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3349530

20 June 2018

Microtumor growth initiates angiogenic sprouting with simultaneous expression of VEGF, VEGF receptor-2, and angiopoietin-2.

1 reference

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Characterization of ten newly-derived human head and neck squamous carcinoma cell lines with special reference to c-erbB proto-oncogene expression.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3349530

20 June 2018

Reversion of the malignant phenotype of human breast cells in three-dimensional culture and in vivo by integrin blocking antibodies

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3349530

20 June 2018

Tenascin mediates human glioma cell migration and modulates cell migration on fibronectin

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3349530

20 June 2018

Ten human carcinoma cell lines derived from squamous carcinomas of the head and neck

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3349530

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High drug attrition rates--where are we going wrong?

1 reference

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Microarrays for the scalable production of metabolically relevant tumour spheroids: a tool for modulating chemosensitivity traits.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3349530

26 November 2018

Genomic and expression profiling of glioblastoma stem cell-like spheroid cultures identifies novel tumor-relevant genes associated with survival.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3349530

26 November 2018

Compact spheroid formation by ovarian cancer cells is associated with contractile behavior and an invasive phenotype.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3349530

26 November 2018

The genomic profile of human malignant glioma is altered early in primary cell culture and preserved in spheroids.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3349530

26 November 2018

PLCgamma1 is essential for early events in integrin signalling required for cell motility

1 reference

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Three-dimensional culture of melanoma cells profoundly affects gene expression profile: a high density oligonucleotide array study.

1 reference

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26 November 2018

Pattern of self-organization in tumour systems: complex growth dynamics in a novel brain tumour spheroid model.

1 reference

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26 November 2018

Glucose transporter glut-1 expression correlates with tumor hypoxia and predicts metastasis-free survival in advanced carcinoma of the cervix

1 reference

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26 November 2018

Tumor-induced angiogenesis studied in confrontation cultures of multicellular tumor spheroids and embryoid bodies grown from pluripotent embryonic stem cells.

1 reference

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26 November 2018

Targeting angiogenesis inhibits tumor infiltration and expression of the pro-invasive protein SPARC.

1 reference

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26 November 2018

Cell culture: biology's new dimension

1 reference

https://pubmed.ncbi.nlm.nih.gov/22439642

12 December 2020

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Development of endothelial cell lines from embryonic stem cells: A tool for studying genetically manipulated endothelial cells in vitro

1 reference

https://pubmed.ncbi.nlm.nih.gov/22439642

12 December 2020

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Growth of multicell spheroids in tissue culture as a model of nodular carcinomas

1 reference

https://pubmed.ncbi.nlm.nih.gov/22439642

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Growing tissues in microgravity

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https://pubmed.ncbi.nlm.nih.gov/22439642

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Oxygenation and differentiation in multicellular spheroids of human colon carcinoma

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based on heuristic

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Identifiers

10.1186/1741-7007-10-29

1 reference

Europe PubMed Central

PMC publication ID

11 August 2017

Dimensions Publication ID

0 references

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

11 August 2017

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

11 August 2017

ResearchGate publication ID

0 references

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