(Q30518054)

English

Zampanolide, a potent new microtubule-stabilizing agent, covalently reacts with the taxane luminal site in tubulin α,β-heterodimers and microtubules

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scholarly article

1 reference

Europe PubMed Central

11 August 2017

Zampanolide, a potent new microtubule-stabilizing agent, covalently reacts with the taxane luminal site in tubulin α,β-heterodimers and microtubules (English)

1 reference

Europe PubMed Central

11 August 2017

author name string

Jessica J Field

1

1 reference

Europe PubMed Central

11 August 2017

Benet Pera

2

1 reference

Europe PubMed Central

11 August 2017

Enrique Calvo

3

1 reference

Europe PubMed Central

11 August 2017

Angeles Canales

4

1 reference

Europe PubMed Central

11 August 2017

Didier Zurwerra

5

1 reference

Europe PubMed Central

11 August 2017

Chiara Trigili

6

1 reference

Europe PubMed Central

11 August 2017

Javier Rodríguez-Salarichs

7

1 reference

Europe PubMed Central

11 August 2017

Ruth Matesanz

8

1 reference

Europe PubMed Central

11 August 2017

Arun Kanakkanthara

9

1 reference

Europe PubMed Central

11 August 2017

St John Wakefield

10

1 reference

Europe PubMed Central

11 August 2017

A Jonathan Singh

11

1 reference

Europe PubMed Central

11 August 2017

Jesús Jiménez-Barbero

12

1 reference

Europe PubMed Central

11 August 2017

Peter Northcote

13

1 reference

Europe PubMed Central

11 August 2017

John H Miller

14

1 reference

Europe PubMed Central

11 August 2017

Juan Antonio López

15

1 reference

Europe PubMed Central

11 August 2017

Ernest Hamel

16

1 reference

Europe PubMed Central

11 August 2017

Isabel Barasoain

17

1 reference

Europe PubMed Central

11 August 2017

Karl-Heinz Altmann

18

1 reference

Europe PubMed Central

11 August 2017

José Fernando Díaz

19

1 reference

Europe PubMed Central

11 August 2017

language of work or name

1 reference

based on heuristic

inferred from title

publication date

1 June 2012

1 reference

Europe PubMed Central

11 August 2017

Chemistry and Biology

1 reference

Europe PubMed Central

11 August 2017

19

1 reference

Europe PubMed Central

11 August 2017

6

1 reference

Europe PubMed Central

11 August 2017

686-698

1 reference

Europe PubMed Central

11 August 2017

Insights into the interaction of discodermolide and docetaxel with tubulin. Mapping the binding sites of microtubule-stabilizing agents by using an integrated NMR and computational approach

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3383615

20 June 2018

Hallmarks of molecular action of microtubule stabilizing agents: effects of epothilone B, ixabepilone, peloruside A, and laulimalide on microtubule conformation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3383615

20 June 2018

Microtubule-binding agents: a dynamic field of cancer therapeutics

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3383615

20 June 2018

Molecular recognition of peloruside A by microtubules. The C24 primary alcohol is essential for biological activity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3383615

20 June 2018

Discovery and characterization of the laulimalide-microtubule binding mode by mass shift perturbation mapping

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3383615

20 June 2018

Synthesis of (-)-dactylolide and 13-desmethylene-(-)-dactylolide and their effects on tubulin

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3383615

20 June 2018

Optimization of taxane binding to microtubules: binding affinity dissection and incremental construction of a high-affinity analog of paclitaxel.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3383615

20 June 2018

The bound conformation of microtubule-stabilizing agents: NMR insights into the bioactive 3D structure of discodermolide and dictyostatin

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3383615

20 June 2018

Overcoming tumor drug resistance with high-affinity taxanes: a SAR study of C2-modified 7-acyl-10-deacetyl cephalomannines.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3383615

20 June 2018

Cyclostreptin binds covalently to microtubule pores and lumenal taxoid binding sites.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3383615

20 June 2018

NMR determination of the bioactive conformation of peloruside A bound to microtubules.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3383615

20 June 2018

Cyclostreptin (FR182877), an antitumor tubulin-polymerizing agent deficient in enhancing tubulin assembly despite its high affinity for the taxoid site

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3383615

20 June 2018

Refined structure of alpha beta-tubulin at 3.5 A resolution

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3383615

20 June 2018

Group epitope mapping by saturation transfer difference NMR to identify segments of a ligand in direct contact with a protein receptor

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3383615

20 June 2018

A new antimitotic substance, FR182877. I. Taxonomy, fermentation, isolation, physico-chemical properties and biological activities.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3383615

20 June 2018

Size-Distribution Analysis of Macromolecules by Sedimentation Velocity Ultracentrifugation and Lamm Equation Modeling

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3383615

20 June 2018

How Taxol stabilises microtubule structure.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3383615

20 June 2018

High-resolution model of the microtubule

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3383615

20 June 2018

Laulimalide and isolaulimalide, new paclitaxel-like microtubule-stabilizing agents.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3383615

20 June 2018

Taxol binds to polymerized tubulin in vitro

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3383615

20 June 2018

Probing the pore drug binding site of microtubules with fluorescent taxanes: evidence of two binding poses

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3383615

26 November 2018

Characterizing ligand-microtubule binding by competition methods.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3383615

26 November 2018

Structural Basis of the Activity of the Microtubule-Stabilizing Agent Epothilone A Studied by NMR Spectroscopy in Solution

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3383615

26 November 2018

The Tubulin-Bound Conformation of Discodermolide Derived by NMR Studies in Solution Supports a Common Pharmacophore Model for Epothilone and Discodermolide

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3383615

26 November 2018

Microtubule interactions with chemically diverse stabilizing agents: thermodynamics of binding to the paclitaxel site predicts cytotoxicity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3383615

26 November 2018

Macromolecular accessibility of fluorescent taxoids bound at a paclitaxel binding site in the microtubule surface.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3383615

26 November 2018

Macrolactonization via Ti(IV)-mediated epoxy-acid coupling: a total synthesis of (-)-dactylolide [and zampanolide].

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3383615

26 November 2018

The High-Resolution Solution Structure of Epothilone A Bound to Tubulin: An Understanding of the Structure–Activity Relationships for a Powerful Class of Antitumor Agents

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3383615

26 November 2018

Fast kinetics of Taxol binding to microtubules. Effects of solution variables and microtubule-associated proteins

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3383615

26 November 2018

The microtubule stabilizing agent laulimalide does not bind in the taxoid site, kills cells resistant to paclitaxel and epothilones, and may not require its epoxide moiety for activity.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3383615

26 November 2018

Thermodynamics of ligand-induced assembly of tubulin.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3383615

26 November 2018

Assembly of purified GDP-tubulin into microtubules induced by taxol and taxotere: reversibility, ligand stoichiometry, and competition.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3383615

26 November 2018

Molecular recognition of taxol by microtubules. Kinetics and thermodynamics of binding of fluorescent taxol derivatives to an exposed site

1 reference

https://pubmed.ncbi.nlm.nih.gov/22726683

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Derivation of Dihedral Angles from CH–CH Dipolar–Dipolar Cross-Correlated Relaxation Rates: A C–C Torsion Involving a Quaternary Carbon Atom in Epothilone A Bound to Tubulin

1 reference

https://pubmed.ncbi.nlm.nih.gov/22726683

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Accounting for ligand-protein interactions in the relaxation-matrix analysis of transferred nuclear Overhauser effects

1 reference

https://pubmed.ncbi.nlm.nih.gov/22726683

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Large scale purification of brain tubulin with the modified Weisenberg procedure

1 reference

https://pubmed.ncbi.nlm.nih.gov/22726683

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Microtubule-stabilizing activity of zampanolide, a potent macrolide isolated from the Tongan marine sponge Cacospongia mycofijiensis

1 reference

https://pubmed.ncbi.nlm.nih.gov/22726683

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Dactylolide, a New Cytotoxic Macrolide from the Vanuatu SpongeDactylospongia sp.

0 references

Identifiers

10.1016/J.CHEMBIOL.2012.05.008

1 reference

Europe PubMed Central

11 August 2017

1 reference

Europe PubMed Central

11 August 2017

1 reference

Europe PubMed Central

11 August 2017

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