(Q30583136)

English

Critical Role for an acidic amino acid region in platelet signaling by the HemITAM (hemi-immunoreceptor tyrosine-based activation motif) containing receptor CLEC-2 (C-type lectin receptor-2).

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scholarly article

1 reference

Europe PubMed Central

PMC publication ID

17 November 2017

Critical Role for an acidic amino acid region in platelet signaling by the HemITAM (hemi-immunoreceptor tyrosine-based activation motif) containing receptor CLEC-2 (C-type lectin receptor-2). (English)

1 reference

Europe PubMed Central

PMC publication ID

17 November 2017

1

1 reference

Europe PubMed Central

PMC publication ID

17 November 2017

Steve P. Watson

6

1 reference

Europe PubMed Central

PMC publication ID

17 November 2017

author name string

Uma Sinha

2

1 reference

Europe PubMed Central

PMC publication ID

17 November 2017

Anjali Pandey

3

1 reference

Europe PubMed Central

PMC publication ID

17 November 2017

Johannes A Eble

4

1 reference

Europe PubMed Central

PMC publication ID

17 November 2017

Christopher A O'Callaghan

5

1 reference

Europe PubMed Central

PMC publication ID

17 November 2017

language of work or name

0 references

publication date

21 December 2012

1 reference

Europe PubMed Central

PMC publication ID

17 November 2017

Journal of Biological Chemistry

1 reference

Europe PubMed Central

PMC publication ID

17 November 2017

288

1 reference

Europe PubMed Central

PMC publication ID

17 November 2017

7

1 reference

Europe PubMed Central

PMC publication ID

17 November 2017

5127-5135

1 reference

Europe PubMed Central

PMC publication ID

17 November 2017

Altered BCR signalling quality predisposes to autoimmune disease and a pre-diabetic state

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3576117

20 June 2018

CLEC-2 and Syk in the megakaryocytic/platelet lineage are essential for development.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3576117

20 June 2018

Syk-dependent phosphorylation of CLEC-2: a novel mechanism of hem-immunoreceptor tyrosine-based activation motif signaling

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3576117

20 June 2018

PRT-060318, a novel Syk inhibitor, prevents heparin-induced thrombocytopenia and thrombosis in a transgenic mouse model

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3576117

20 June 2018

Essential in vivo roles of the C-type lectin receptor CLEC-2: embryonic/neonatal lethality of CLEC-2-deficient mice by blood/lymphatic misconnections and impaired thrombus formation of CLEC-2-deficient platelets.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3576117

20 June 2018

Platelets regulate lymphatic vascular development through CLEC-2-SLP-76 signaling

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3576117

20 June 2018

Interaction of C-type lectin-like receptors NKp65 and KACL facilitates dedicated immune recognition of human keratinocytes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3576117

20 June 2018

The platelet receptor CLEC-2 is active as a dimer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3576117

20 June 2018

CLEC-2 is a phagocytic activation receptor expressed on murine peripheral blood neutrophils.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3576117

20 June 2018

G6b-B inhibits constitutive and agonist-induced signaling by glycoprotein VI and CLEC-2

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3576117

20 June 2018

CLEC9A is a novel activation C-type lectin-like receptor expressed on BDCA3+ dendritic cells and a subset of monocytes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3576117

20 June 2018

Cardiac malformations and myocardial abnormalities in podoplanin knockout mouse embryos: Correlation with abnormal epicardial development.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3576117

20 June 2018

Involvement of the snake toxin receptor CLEC-2, in podoplanin-mediated platelet activation, by cancer cells.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3576117

20 June 2018

The C-type lectin receptors CLEC-2 and Dectin-1, but not DC-SIGN, signal via a novel YXXL-dependent signaling cascade

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3576117

20 June 2018

The crystal structure and mutational binding analysis of the extracellular domain of the platelet-activating receptor CLEC-2.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3576117

20 June 2018

A novel Syk-dependent mechanism of platelet activation by the C-type lectin receptor CLEC-2.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3576117

20 June 2018

Dectin-1 activates Syk tyrosine kinase in a dynamic subset of macrophages for reactive oxygen production

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3576117

20 June 2018

Expression and function of Tec, Itk, and Btk in lymphocytes: evidence for a unique role for Tec

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3576117

20 June 2018

T1alpha, a lung type I cell differentiation gene, is required for normal lung cell proliferation and alveolus formation at birth

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3576117

20 June 2018

Regulation of blood and lymphatic vascular separation by signaling proteins SLP-76 and Syk.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3576117

20 June 2018

Cloning of human DECTIN-1, a novel C-type lectin-like receptor gene expressed on dendritic cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3576117

20 June 2018

alpha 2beta 1 integrin is not recognized by rhodocytin but is the specific, high affinity target of rhodocetin, an RGD-independent disintegrin and potent inhibitor of cell adhesion to collagen

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3576117

20 June 2018

Genetic evidence for differential coupling of Syk family kinases to the T-cell receptor: reconstitution studies in a ZAP-70-deficient Jurkat T-cell line

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3576117

20 June 2018

Regulation of T-cell antigen receptor signalling by Syk tyrosine protein kinase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3576117

20 June 2018

Modified phage peptide libraries as a tool to study specificity of phosphorylation and recognition of tyrosine containing peptides

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3576117

20 June 2018

c-rel regulation of IL-2 gene expression may be mediated through activation of AP-1.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3576117

20 June 2018

Differential intrinsic enzymatic activity of Syk and Zap-70 protein-tyrosine kinases

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3576117

20 June 2018

Catalytic specificity of phosphotyrosine kinases Blk, Lyn, c-Src and Syk as assessed by phage display

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3576117

20 June 2018

Reconstitution of B cell antigen receptor-induced signaling events in a nonlymphoid cell line by expressing the Syk protein-tyrosine kinase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3576117

20 June 2018

Analysis of Ig-alpha-tyrosine kinase interaction reveals two levels of binding specificity and tyrosine phosphorylated Ig-alpha stimulation of Fyn activity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3576117

20 June 2018

Molecular basis for interaction of the protein tyrosine kinase ZAP-70 with the T-cell receptor

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3576117

20 June 2018

Syk Mutation in Jurkat E6-derived Clones Results in Lack of p72syk Expression

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3576117

20 June 2018

Temporal regulation of non-transmembrane protein tyrosine kinase enzyme activity following T cell antigen receptor engagement

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3576117

20 June 2018

Association of the 72-kDa protein-tyrosine kinase PTK72 with the B cell antigen receptor

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3576117

20 June 2018

CLEC-2 activates Syk through dimerization

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M112.411462

21 January 2018

Phosphorylation of CLEC-2 is dependent on lipid rafts, actin polymerization, secondary mediators, and Rac.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M112.411462

21 January 2018

The novel Syk inhibitor R406 reveals mechanistic differences in the initiation of GPVI and CLEC-2 signaling in platelets.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M112.411462

21 January 2018

Syk and Slp-76 mutant mice reveal a cell-autonomous hematopoietic cell contribution to vascular development.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M112.411462

21 January 2018

Evaluation of the role of platelet integrins in fibronectin-dependent spreading and adhesion

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M112.411462

21 January 2018

Thermodynamic Study of the Binding of the Tandem-SH2 Domain of the Syk Kinase to a Dually Phosphorylated ITAM Peptide: Evidence for Two Conformers†

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M112.411462

21 January 2018

FcgammaRII tyrosine phosphorylation differs between FcgammaRII cross-linking and platelet-activating anti-platelet monoclonal antibodies

1 reference

https://pubmed.ncbi.nlm.nih.gov/23264619

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Phospholipase Cgamma2 is necessary for separation of blood and lymphatic vasculature in mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/23264619

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1074/JBC.M112.411462

1 reference

Europe PubMed Central

PMC publication ID

17 November 2017

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

17 November 2017

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

17 November 2017

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