(Q3062781)

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P30542

G protein-coupled receptor

1 reference

Transporter Classification Database ID

9.A.14.3.4

hierarchical database ID heuristic

2 October 2019

based on heuristic

GPCR, rhodopsin-like, 7TM, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

13 November 2019

1 reference

13 November 2019

G-protein beta/gamma-subunit complex binding

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30542

signal transducer activity

1 reference

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P30542&geneProductId=UniProtKB:P30542

purine nucleoside binding

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30542

protein heterodimerization activity

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30542

phospholipase C activity

1 reference

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P30542&geneProductId=UniProtKB:P30542

heterotrimeric G-protein binding

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30542

G protein-coupled receptor binding

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30542

heat shock protein binding

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30542

neurotransmitter receptor activity involved in regulation of presynaptic cytosolic calcium ion concentration

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30542

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30542

postsynaptic membrane

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30542

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30542

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30542

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30542

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30542

integral component of plasma membrane

1 reference

8 April 2019

Cloning and functional characterization of a human A1 adenosine receptor

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30542

presynaptic active zone

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30542

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30542

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30542

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30542

basolateral plasma membrane

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30542

endoplasmic reticulum

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30542

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30542

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30542

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30542

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30542

5 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30542

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30542

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30542

8 April 2019

Mutation in ADORA1 identified as likely cause of early-onset parkinsonism and cognitive dysfunction.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30542

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30542

integral component of postsynaptic membrane

IDA

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30542

integral component of presynaptic membrane

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30542

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30542

negative regulation of circadian sleep/wake cycle, non-REM sleep

biological process

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30542

positive regulation of nucleoside transport

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30542

positive regulation of epidermal growth factor-activated receptor activity

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30542

G protein-coupled adenosine receptor signaling pathway

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30542

negative regulation of neurotrophin production

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30542

negative regulation of glutamate secretion

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30542

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30542

negative regulation of acute inflammatory response

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30542

adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30542

regulation of sensory perception of pain

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30542

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30542

positive regulation of protein dephosphorylation

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30542

negative regulation of blood pressure

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30542

negative regulation of heart contraction

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30542

protein targeting to membrane

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30542

positive regulation of potassium ion transport

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30542

regulation of glomerular filtration

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30542

1 reference

8 April 2019

Adenosine stimulates DNA fragmentation in human thymocytes by Ca(2+)-mediated mechanisms

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30542

positive regulation of peptide secretion

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30542

negative regulation of apoptotic process

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30542

nervous system development

1 reference

8 April 2019

Reduced density of adenosine A1 receptors and preserved coupling of adenosine A1 receptors to G proteins in Alzheimer hippocampus: a quantitative autoradiographic study

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30542

detection of temperature stimulus involved in sensory perception of pain

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30542

regulation of respiratory gaseous exchange by nervous system process

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30542

lipid catabolic process

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30542

negative regulation of circadian sleep/wake cycle, sleep

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30542

positive regulation of blood pressure

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30542

negative regulation of synaptic transmission, GABAergic

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30542

negative regulation of renal sodium excretion

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30542

excitatory postsynaptic potential

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30542

1 reference

8 April 2019

Human mononuclear phagocytes express adenosine A1 receptors. A novel mechanism for differential regulation of Fc gamma receptor function

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30542

relaxation of vascular associated smooth muscle

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30542

apoptotic signaling pathway

1 reference

8 April 2019

Adenosine stimulates DNA fragmentation in human thymocytes by Ca(2+)-mediated mechanisms

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30542

regulation of cardiac muscle contraction

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30542

negative regulation of long-term synaptic depression

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30542

temperature homeostasis

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30542

Human mononuclear phagocytes express adenosine A1 receptors. A novel mechanism for differential regulation of Fc gamma receptor function

inflammatory response

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30542

negative regulation of mucus secretion

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30542

negative regulation of hormone secretion

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30542

negative regulation of lipid catabolic process

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30542

negative regulation of inflammatory response

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30542

negative regulation of leukocyte migration

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30542

negative regulation of synaptic transmission, glutamatergic

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30542

negative regulation of cell population proliferation

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30542

negative regulation of cardiac muscle contraction

1 reference

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P30542&geneProductId=UniProtKB:P30542

G protein-coupled receptor signaling pathway

4 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30542

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30542

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30542

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30542

positive regulation of systemic arterial blood pressure

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30542

negative regulation of systemic arterial blood pressure

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30542

positive regulation of lipid catabolic process

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30542

fatty acid homeostasis

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30542

triglyceride homeostasis

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30542

negative regulation of long-term synaptic potentiation

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30542

positive regulation of neuron death

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30542

regulation of cardiac muscle cell contraction

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30542

regulation of presynaptic cytosolic calcium ion concentration

1 reference

8 April 2019

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30542

physically interacts with

1 reference

2844

17 August 2016

1 reference

3289

17 August 2016

1 reference

5596

17 August 2016

2 references

374

17 August 2016

379

17 August 2016

1 reference

375

17 August 2016

1 reference

380

8-cyclopentyltheophylline

17 August 2016

has use

antagonist

1 reference

385

17 August 2016

1 reference

407

17 August 2016

1 reference

384

8-cyclopentyl-1,3-dipropylxanthine

17 August 2016

has use

antagonist

1 reference

386

17 August 2016

isobutylmethylxanthine

has use

antagonist

1 reference

388

17 August 2016

1 reference

5608

17 August 2016

1 reference

5614

17 August 2016

1 reference

5604

17 August 2016

1 reference

3283

17 August 2016

1 reference

403

17 August 2016

1 reference

413

17 August 2016

1 reference

405

17 August 2016

1 reference

14 August 2023

https://platform.opentargets.org/drug/CHEMBL477

1 reference

14 August 2023

https://platform.opentargets.org/drug/CHEMBL440115

1 reference

14 August 2023

https://platform.opentargets.org/drug/CHEMBL3545011

1 reference

14 August 2023

https://platform.opentargets.org/drug/CHEMBL392149

1 reference

14 August 2023

https://platform.opentargets.org/drug/CHEMBL414157

Gene Atlas image

PBB GE ADORA1 216220 s at fs.png
732 × 530; 12 KB

0 references

has part(s)

GPCR, rhodopsin-like, 7TM

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P30542

Identifiers

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

13 November 2019

1 reference

1 reference

1 reference

1 reference

1 reference

1 reference

1 reference

28 October 2013

ScienceDirect topic ID

agricultural-and-biological-sciences/adenosine-a1-receptor

0 references

Transporter Classification Database ID

9.A.14.3.4

2 references

Transporter Classification database

13 March 2020

Transporter Classification database