(Q30726891)

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Ligand modulation of glial activation: cell permeable, small molecule inhibitors of serine-threonine protein kinases can block induction of interleukin 1 beta and nitric oxide synthase II.

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11 November 2019

Ligand modulation of glial activation: cell permeable, small molecule inhibitors of serine-threonine protein kinases can block induction of interleukin 1 beta and nitric oxide synthase II (English)

1 reference

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11 November 2019

Daniel Watterson

1

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11 November 2019

author name string

S Mirzoeva

2

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11 November 2019

L Guo

3

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11 November 2019

A Whyte

4

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11 November 2019

J J Bourguignon

5

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11 November 2019

M Hibert

6

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11 November 2019

J Haiech

7

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11 November 2019

L J Van Eldik

8

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11 November 2019

publication date

1 November 2001

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11 November 2019

Neurochemistry International

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11 November 2019

39

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11 November 2019

459-468

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11 November 2019

5-6

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11 November 2019

Beta-amyloid stimulation of inducible nitric-oxide synthase in astrocytes is interleukin-1beta- and tumor necrosis factor-alpha (TNFalpha)-dependent, and involves a TNFalpha receptor-associated factor- and NFkappaB-inducing kinase-dependent signalin

1 reference

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Amyloid beta-peptide stimulates nitric oxide production in astrocytes through an NFkappaB-dependent mechanism

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Inflammation and Alzheimer's disease

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Gene-regulating protein kinases as important anti-inflammatory targets

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Extracellular signal-regulated kinase and p38 subgroups of mitogen-activated protein kinases regulate inducible nitric oxide synthase and tumor necrosis factor-alpha gene expression in endotoxin-stimulated primary glial cultures

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7 January 2021

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Defining Ca2+/calmodulin-dependent protein kinase cascades in transcriptional regulation

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7 January 2021

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Blockade of p38 mitogen-activated protein kinase pathway inhibits inducible nitric-oxide synthase expression in mouse astrocytes

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Association of an interleukin 1 alpha polymorphism with Alzheimer's disease

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Staurosporine and K-252 compounds protect hippocampal neurons against amyloid beta-peptide toxicity and oxidative injury.

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Brain interleukin 1 and S-100 immunoreactivity are elevated in Down syndrome and Alzheimer disease

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7 January 2021

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Interleukin-1 expression in different plaque types in Alzheimer's disease: significance in plaque evolution.

1 reference

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7 January 2021

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Association of early-onset Alzheimer's disease with an interleukin-1? gene polymorphism

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7 January 2021

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Chronic neuroinflammation in rats reproduces components of the neurobiology of Alzheimer's disease

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Pharmacologically active pyridazine derivatives. Part 1.

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7 January 2021

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Glial-derived proteins activate cultured astrocytes and enhance beta amyloid-induced glial activation.

1 reference

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7 January 2021

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S100 beta stimulates inducible nitric oxide synthase activity and mRNA levels in rat cortical astrocytes.

1 reference

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7 January 2021

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S100beta induces neuronal cell death through nitric oxide release from astrocytes

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7 January 2021

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NSAIDs and incident Alzheimer’s disease. the Rotterdam study

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7 January 2021

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Critical amino acid residues of AIP, a highly specific inhibitory peptide of calmodulin-dependent protein kinase II.

1 reference

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7 January 2021

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Neurotrophic 3,9-bis[(alkylthio)methyl]-and-bis(alkoxymethyl)-K-252a derivatives

1 reference

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7 January 2021

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K-252a, a potent inhibitor of protein kinase C from microbial origin

1 reference

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7 January 2021

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K-252 compounds, novel and potent inhibitors of protein kinase C and cyclic nucleotide-dependent protein kinases

1 reference

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7 January 2021

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Inhibition of p38 MAP kinase as a therapeutic strategy

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7 January 2021

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Neuronal-glial interactions mediated by interleukin-1 enhance neuronal acetylcholinesterase activity and mRNA expression.

1 reference

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7 January 2021

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Identification of novel classes of protein kinase inhibitors using combinatorial peptide chemistry based on functional genomics knowledge

1 reference

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7 January 2021

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Oxidative stress hypothesis in Alzheimer's disease

1 reference

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7 January 2021

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Oxidative alterations in Alzheimer's disease.

1 reference

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7 January 2021

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K-252a induces tyrosine phosphorylation of the focal adhesion kinase and neurite outgrowth in human neuroblastoma SH-SY5Y cells.

1 reference

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7 January 2021

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Screening in a cell-based assay for inhibitors of microglial nitric oxide production reveals calmodulin-regulated protein kinases as potential drug discovery targets

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7 January 2021

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Glial cytokines in Alzheimer's disease: review and pathogenic implications

1 reference

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7 January 2021

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K-252a and staurosporine selectively block autophosphorylation of neurotrophin receptors and neurotrophin-mediated responses

1 reference

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7 January 2021

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Inhibition of the cellular actions of nerve growth factor by staurosporine and K252A results from the attenuation of the activity of the trk tyrosine kinase

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7 January 2021

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beta-Amyloid regulates gene expression of glial trophic substance S100 beta in C6 glioma and primary astrocyte cultures

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Cyclopentenone prostaglandins suppress activation of microglia: down-regulation of inducible nitric-oxide synthase by 15-deoxy-Delta12,14-prostaglandin J2

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Modulation of glial activation by astrocyte-derived protein S100B: differential responses of astrocyte and microglial cultures

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Rescue of hearing, auditory hair cells, and neurons by CEP-1347/KT7515, an inhibitor of c-Jun N-terminal kinase activation

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Confirmation of the genetic association of interleukin-1A with early onset sporadic Alzheimer's disease.

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1 reference

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1 reference

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Identifiers

10.1016/S0197-0186(01)00053-5

1 reference

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11 November 2019

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11 November 2019

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