(Q30788870)

26 June 2017

title

NMR techniques for characterization of ligand binding: utility for lead generation and optimization in drug discovery (English)

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26 June 2017

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Moore JM

1

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26 June 2017

publication date

1 January 1999

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26 June 2017

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26 June 2017

volume

51

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26 June 2017

issue

3

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26 June 2017

page(s)

221-243

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NMR spectroscopy in structure-based drug design

26 June 2017

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NMR screening in drug discovery.

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Discovering high-affinity ligands for proteins: SAR by NMR

21 January 2018

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Screening mixtures for biological activity by NMR.

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The SHAPES strategy: an NMR-based approach for lead generation in drug discovery.

21 January 2018

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The properties of known drugs. 1. Molecular frameworks

21 January 2018

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Significant conformational changes in an antigenic carbohydrate epitope upon binding to a monoclonal antibody

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Virtual screening—an overview

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The structural basis for the specificity of pyridinylimidazole inhibitors of p38 MAP kinase

21 January 2018

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SB 203580 is a specific inhibitor of a MAP kinase homologue which is stimulated by cellular stresses and interleukin-1

21 January 2018

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The two-dimensional transferred nuclear Overhauser effect: theory and practice

21 January 2018

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The design and development of an immunosuppressive drug, mycophenolate mofetil

21 January 2018

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Mycophenolic acid and thiazole adenine dinucleotide inhibition of Tritrichomonas foetus inosine 5'-monophosphate dehydrogenase: implications on enzyme mechanism

21 January 2018

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Conformational changes and stabilization of inosine 5'-monophosphate dehydrogenase associated with ligand binding and inhibition by mycophenolic acid

21 January 2018

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Inhibition of IMPDH by mycophenolic acid: dissection of forward and reverse pathways using capillary electrophoresis

21 January 2018

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Structure and mechanism of inosine monophosphate dehydrogenase in complex with the immunosuppressant mycophenolic acid

21 January 2018

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Probing the active site of human IMP dehydrogenase using halogenated purine riboside 5'-monophosphates and covalent modification reagents

21 January 2018

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Inosine 5'-phosphate dehydrogenase. Kinetic mechanism and evidence for selective reaction of the 6-chloro analog of inosine 5'-phosphate with a cysteine residue at the inosine 5'-phosphate site

21 January 2018

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Solution structure of FK506 bound to FKBP-12

21 January 2018

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Practical applications of time-averaged restrained molecular dynamics to ligand-receptor systems: FK506 bound to the Q50R,A95H,K98I triple mutant of FKBP-13.

21 January 2018

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Atomic structures of the human immunophilin FKBP-12 complexes with FK506 and rapamycin

21 January 2018

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Identification of solvent-exposed regions of an FK-506 analog, ascomycin, bound to FKBP using a paramagnetic probe.

21 January 2018

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NMR studies of an FK-506 analog, [U-13C]ascomycin, bound to FK-506-binding protein

21 January 2018

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Atomic structure of FKBP-FK506, an immunophilin-immunosuppressant complex

21 January 2018

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Calcineurin is a common target of cyclophilin-cyclosporin A and FKBP-FK506 complexes

21 January 2018

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Molecular cloning of a membrane-associated human FK506- and rapamycin-binding protein, FKBP-13

21 January 2018

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Mixture Analysis in Combinatorial Chemistry. Application of Diffusion-Resolved NMR Spectroscopy

21 January 2018

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Isotope-Filtered Affinity NMR

21 January 2018

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Solution structure of FK506 bound to the R42K, H87V double mutant of FKBP-12

21 January 2018

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Conformation of two non-immunosuppressive FK506 analogs when bound to FKBP by isotope-filtered NMR

21 January 2018

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15N NMR relaxation studies of the FK506 binding protein: backbone dynamics of the uncomplexed receptor

21 January 2018

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15N NMR relaxation studies of the FK506 binding protein: dynamic effects of ligand binding and implications for calcineurin recognition

21 January 2018

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FK506 binding protein mutational analysis. Defining the surface residue contributions to stability of the calcineurin co-complex

21 January 2018

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10.1002/(SICI)1097-0282(1999)51:3<221::AID-BIP5>3.0.CO;2-9

21 January 2018

Identifiers

DOI

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26 June 2017

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