(Q30870481)

27 June 2017

title

Why does threonine, and not serine, function as the active site nucleophile in proteasomes? (English)

1 reference

27 June 2017

Kisselev AF

1

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27 June 2017

Songyang Z

series ordinal

2

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27 June 2017

Goldberg AL

series ordinal

3

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27 June 2017

language of work or name

English

0 references

publication date

1 May 2000

1 reference

Journal of Biological Chemistry

27 June 2017

published in

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27 June 2017

volume

275

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27 June 2017

issue

20

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27 June 2017

page(s)

14831-14837

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Inhibitors of the proteasome block the degradation of most cell proteins and the generation of peptides presented on MHC class I molecules

27 June 2017

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Conformational constraints in protein degradation by the 20S proteasome

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An archaebacterial ATPase, homologous to ATPases in the eukaryotic 26 S proteasome, activates protein breakdown by 20 S proteasomes

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Cleavage motifs of the yeast 20S proteasome beta subunits deduced from digests of enolase 1.

21 January 2018

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Primary structure of the Thermoplasma proteasome and its implications for the structure, function, and evolution of the multicatalytic proteinase

21 January 2018

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A protein catalytic framework with an N-terminal nucleophile is capable of self-activation

21 January 2018

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Structure of the allosteric regulatory enzyme of purine biosynthesis

21 January 2018

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Histone mRNA in Xenopus laevis ovaries: identification of the H4 messenger

21 January 2018

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Three-dimensional structure of Escherichia coli asparagine synthetase B: a short journey from substrate to product

21 January 2018

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Effects of site-directed mutations on processing and activities of penicillin G acylase from Escherichia coli ATCC 11105

21 January 2018

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Penicillin acylase has a single-amino-acid catalytic centre

21 January 2018

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Three-dimensional structure of human lysosomal aspartylglucosaminidase

21 January 2018

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HslV-HslU: A novel ATP-dependent protease complex in Escherichia coli related to the eukaryotic proteasome

21 January 2018

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Proteasome from Thermoplasma acidophilum: a threonine protease

21 January 2018

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The active sites of the eukaryotic 20 S proteasome and their involvement in subunit precursor processing

21 January 2018

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Autocatalytic subunit processing couples active site formation in the 20S proteasome to completion of assembly

21 January 2018

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Identification of the yeast 20S proteasome catalytic centers and subunit interactions required for active-site formation

21 January 2018

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Contribution of proteasomal beta-subunits to the cleavage of peptide substrates analyzed with yeast mutants

21 January 2018

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Inhibition of proteasome activities and subunit-specific amino-terminal threonine modification by lactacystin

21 January 2018

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Structure of 20S proteasome from yeast at 2.4 A resolution

21 January 2018

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Reactions of [14C]-3,4-dichloroisocoumarin with subunits of pituitary and spleen multicatalytic proteinase complexes (proteasomes).

21 January 2018

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Covalent modification of the active site threonine of proteasomal beta subunits and the Escherichia coli homolog HslV by a new class of inhibitors

21 January 2018

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The catalytic sites of 20S proteasomes and their role in subunit maturation: a mutational and crystallographic study

21 January 2018

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Eukaryotic 20S proteasome catalytic subunit propeptides prevent active site inactivation by N-terminal acetylation and promote particle assembly

21 January 2018

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Structure and function of the 20S proteasome and of its regulatory complexes

21 January 2018

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Autocatalytic processing of the 20S proteasome

21 January 2018

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A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding

21 January 2018

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Calculation of protein extinction coefficients from amino acid sequence data

21 January 2018

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Catalytic mechanism of the 20S proteasome of Thermoplasma acidophilum revealed by X-ray crystallography

21 January 2018

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Mechanistic studies on the inactivation of the proteasome by lactacystin: a central role for clasto-lactacystin beta-lactone

21 January 2018

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Epoxomicin, a potent and selective proteasome inhibitor, exhibits in vivo antiinflammatory activity

21 January 2018

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Recognition of the polyubiquitin proteolytic signal

21 January 2018

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Proteasome inhibitors: valuable new tools for cell biologists

21 January 2018

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New insights on the specificity of penicillin acylase.

21 January 2018

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Crystal structures of Flavobacterium glycosylasparaginase. An N-terminal nucleophile hydrolase activated by intramolecular proteolysis

21 January 2018

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Processive degradation of proteins and other catalytic properties of the proteasome from Thermoplasma acidophilum

21 January 2018

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Range of sizes of peptide products generated during degradation of different proteins by archaeal proteasomes

21 January 2018

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The sizes of peptides generated from protein by mammalian 26 and 20 S proteasomes. Implications for understanding the degradative mechanism and antigen presentation

21 January 2018

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Critical elements in proteasome assembly

21 January 2018

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Proteasome β-type subunits: unequal roles of propeptides in core particle maturation and a hierarchy of active site function

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.275.20.14831

Site-directed mutagenesis of essential residues involved in the mechanism of bacterial glycosylasparaginase

21 January 2018

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Human polyomavirus BK and immunogenicity of mammalian DNA: a conceptual framework

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.275.20.14831

Proteasome active sites allosterically regulate each other, suggesting a cyclical bite-chew mechanism for protein breakdown

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.275.20.14831

Fluorescamine: A Reagent for Assay of Amino Acids, Peptides, Proteins, and Primary Amines in the Picomole Range

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.275.20.14831

Kinetic studies of the branched chain amino acid preferring peptidase activity of the 20S proteasome: development of a continuous assay and inhibition by tripeptide aldehydes and clasto-lactacystin beta-lactone

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.275.20.14831

21 January 2018

Identifiers

DOI

10.1074/JBC.275.20.14831

1 reference

27 June 2017

1 reference