(Q30886181)

English

Nonparametric expectation maximisation (NPEM) population pharmacokinetic analysis of caffeine disposition from sparse data in adult caucasians: systemic caffeine clearance as a biomarker for cytochrome P450 1A2 activity

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scholarly article

1 reference

Europe PubMed Central

PubMed publication ID

27 June 2017

Nonparametric expectation maximisation (NPEM) population pharmacokinetic analysis of caffeine disposition from sparse data in adult caucasians: systemic caffeine clearance as a biomarker for cytochrome P450 1A2 activity (English)

1 reference

Europe PubMed Central

PubMed publication ID

27 June 2017

0 references

pharmacokinetics

1 reference

based on heuristic

inferred from title

1 reference

based on heuristic

inferred from title

author name string

Dimiter Terziivanov

1

1 reference

Europe PubMed Central

PubMed publication ID

27 June 2017

Kristina Bozhinova

2

1 reference

Europe PubMed Central

PubMed publication ID

27 June 2017

Velislava Dimitrova

3

1 reference

Europe PubMed Central

PubMed publication ID

27 June 2017

Ivanka Atanasova

4

1 reference

Europe PubMed Central

PubMed publication ID

27 June 2017

language of work or name

1 reference

based on heuristic

inferred from title

publication date

1 January 2003

1 reference

Europe PubMed Central

PubMed publication ID

27 June 2017

Clinical Pharmacokinetics

1 reference

Europe PubMed Central

PubMed publication ID

27 June 2017

42

1 reference

Europe PubMed Central

PubMed publication ID

27 June 2017

15

1 reference

Europe PubMed Central

PubMed publication ID

27 June 2017

1393-1409

1 reference

Europe PubMed Central

PubMed publication ID

27 June 2017

https://scigraph.springernature.com/pub.10.2165/00003088-200342150-00006

0 references

Biochemical individuality and its implications for drug and carcinogen metabolism: recent insights from acetyltransferase and cytochrome P4501A2 phenotyping and genotyping in humans

1 reference

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Inter-individual differences in the metabolism of environmental toxicants: cytochrome P450 1A2 as a prototype

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Interaction between oral ciprofloxacin and caffeine in normal volunteers

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Testing for bimodality in frequency distributions of data suggesting polymorphisms of drug metabolism--histograms and probit plots

1 reference

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21 January 2018

Testing for bimodality in frequency distributions of data suggesting polymorphisms of drug metabolism--hypothesis testing

1 reference

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21 January 2018

A new, sensitive graphical method for detecting deviations from the normal distribution of drug responses: the NTV plot

1 reference

https://api.crossref.org/works/10.2165%2F00003088-200342150-00006

21 January 2018

Biomarkers and surrogate endpoints: preferred definitions and conceptual framework

1 reference

https://pubmed.ncbi.nlm.nih.gov/14674790

12 December 2020

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Biotransformation of caffeine, paraxanthine, theobromine and theophylline by cDNA-expressed human CYP1A2 and CYP2E1

1 reference

https://pubmed.ncbi.nlm.nih.gov/14674790

12 December 2020

based on heuristic

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A urinary metabolite ratio that reflects systemic caffeine clearance

1 reference

https://pubmed.ncbi.nlm.nih.gov/14674790

12 December 2020

based on heuristic

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4-quinolones inhibit biotransformation of caffeine

1 reference

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Quantitation of three-month intraindividual variability and influence of sex and menstrual cycle phase on CYP1A2, N-acetyltransferase-2, and xanthine oxidase activity determined with caffeine phenotyping

1 reference

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12 December 2020

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A distribution study of CYP1A2 phenotypes among smokers and non-smokers in a cohort of healthy Caucasian volunteers.

1 reference

https://pubmed.ncbi.nlm.nih.gov/14674790

12 December 2020

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Role of human cytochromes P450 in the metabolic activation of chemical carcinogens and toxins

1 reference

https://pubmed.ncbi.nlm.nih.gov/14674790

12 December 2020

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Caffeine metabolism before and after liver transplantation

1 reference

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12 December 2020

based on heuristic

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Caffeine disposition after oral doses

1 reference

https://pubmed.ncbi.nlm.nih.gov/14674790

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Human liver microsomal cytochrome P-450 enzymes involved in the bioactivation of procarcinogens detected by umu gene response in Salmonella typhimurium TA 1535/pSK1002.

1 reference

https://pubmed.ncbi.nlm.nih.gov/14674790

12 December 2020

based on heuristic

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Overnight salivary caffeine clearance: a liver function test suitable for routine use.

1 reference

https://pubmed.ncbi.nlm.nih.gov/14674790

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Variability in caffeine metabolism

1 reference

https://pubmed.ncbi.nlm.nih.gov/14674790

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The cytochrome P450 I gene family of microsomal hemoproteins and their role in the metabolic activation of chemicals

1 reference

https://pubmed.ncbi.nlm.nih.gov/14674790

12 December 2020

based on heuristic

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Racial and gender differences in N-acetyltransferase, xanthine oxidase, and CYP1A2 activities

1 reference

https://pubmed.ncbi.nlm.nih.gov/14674790

12 December 2020

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Simultaneous assessment of CYP3A4 and CYP1A2 activity in vivo with alprazolam and caffeine.

1 reference

https://pubmed.ncbi.nlm.nih.gov/14674790

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The P450 superfamily: update on new sequences, gene mapping, and recommended nomenclature

1 reference

https://pubmed.ncbi.nlm.nih.gov/14674790

12 December 2020

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Simple and reliable CYP1A2 phenotyping by the paraxanthine/caffeine ratio in plasma and in saliva.

1 reference

https://pubmed.ncbi.nlm.nih.gov/14674790

12 December 2020

based on heuristic

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Limitations of probit plots in pharmacogenetics: requirement of genetic analyses to test hypotheses based on graphical methods

1 reference

https://pubmed.ncbi.nlm.nih.gov/14674790

12 December 2020

based on heuristic

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The importance of modeling interoccasion variability in population pharmacokinetic analyses

1 reference

https://pubmed.ncbi.nlm.nih.gov/14674790

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Caffeine metabolism in a group of 67 patients with primary biliary cirrhosis.

1 reference

https://pubmed.ncbi.nlm.nih.gov/14674790

12 December 2020

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Pharmacokinetic variability of nimodipine disposition after single and multiple oral dosing to hypertensive renal failure patients: parametric and nonparametric population analysis

1 reference

https://pubmed.ncbi.nlm.nih.gov/14674790

12 December 2020

based on heuristic

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Human cytochrome P-450PA (P-450IA2), the phenacetin O-deethylase, is primarily responsible for the hepatic 3-demethylation of caffeine and N-oxidation of carcinogenic arylamines

1 reference

https://pubmed.ncbi.nlm.nih.gov/14674790

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Urinary caffeine metabolites in man. Age-dependent changes and pattern in various clinical situations

1 reference

https://pubmed.ncbi.nlm.nih.gov/14674790

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Variation of CYP1A2-dependent caffeine metabolism during menstrual cycle in healthy women.

1 reference

https://pubmed.ncbi.nlm.nih.gov/14674790

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Estimation of cytochrome P-450 CYP1A2 activity in 863 healthy Caucasians using a saliva-based caffeine test.

1 reference

https://pubmed.ncbi.nlm.nih.gov/14674790

12 December 2020

based on heuristic

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Nonparametric expectation maximization population modeling of ganciclovir.

1 reference

https://pubmed.ncbi.nlm.nih.gov/14674790

12 December 2020

based on heuristic

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The paraxanthine:caffeine ratio in serum or in saliva as a measure of CYP1A2 activity: when should the sample be obtained?

1 reference

https://pubmed.ncbi.nlm.nih.gov/14674790

12 December 2020

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Model-based, goal-oriented, individualised drug therapy. Linkage of population modelling, new 'multiple model' dosage design, bayesian feedback and individualised target goals

1 reference

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Rapid metabolic phenotypes for acetyltransferase and cytochrome P4501A2 and putative exposure to food-borne heterocyclic amines increase the risk for colorectal cancer or polyps.

1 reference

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12 December 2020

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Interindividual variations in human liver cytochrome P-450 enzymes involved in the oxidation of drugs, carcinogens and toxic chemicals: studies with liver microsomes of 30 Japanese and 30 Caucasians.

1 reference

https://pubmed.ncbi.nlm.nih.gov/14674790

12 December 2020

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Evaluation of caffeine as an in vivo probe for CYP1A2 using measurements in plasma, saliva, and urine

1 reference

https://pubmed.ncbi.nlm.nih.gov/14674790

12 December 2020

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Population pharmacokinetics of nortriptyline during monotherapy and during concomitant treatment with drugs that inhibit CYP2D6--an evaluation with the nonparametric maximum likelihood method

1 reference

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Caffeine urinary metabolite ratios as markers of enzyme activity: a theoretical assessment.

1 reference

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Some suggestions for measuring predictive performance

1 reference

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Dose-dependency of caffeine metabolism with repeated dosing

1 reference

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12 December 2020

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inferred from PubMed ID database lookup

Use of caffeine metabolite ratios to explore CYP1A2 and xanthine oxidase activities

1 reference

https://pubmed.ncbi.nlm.nih.gov/14674790

12 December 2020

based on heuristic

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Clinically significant pharmacokinetic interactions between dietary caffeine and medications

1 reference

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based on heuristic

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The use of caffeine for enzyme assays: a critical appraisal

1 reference

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12 December 2020

based on heuristic

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Determination of CYP1A2 and NAT2 phenotypes in human populations by analysis of caffeine urinary metabolites.

1 reference

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Quantitative assessment of caffeine partial clearances in man.

1 reference

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The absolute bioavailability of caffeine in man

1 reference

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A simple useful method for the determination of hepatic function in patients with liver cirrhosis using caffeine and its three major dimethylmetabolites

1 reference

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Caffeine as a metabolic probe: exploration of the enzyme-inducing effect of cigarette smoking

1 reference

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Expression of CYP1A1 and CYP1A2 genes in human liver

1 reference

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Stability and performance of a population pharmacokinetic model

1 reference

https://pubmed.ncbi.nlm.nih.gov/14674790

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Relationship between the severity of alcoholic liver cirrhosis and the metabolism of caffeine in 226 patients

1 reference

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based on heuristic

inferred from PubMed ID database lookup

Use of quantitative liver function tests--caffeine clearance and galactose elimination capacity--after orthotopic liver transplantation

1 reference

https://pubmed.ncbi.nlm.nih.gov/14674790

12 December 2020

based on heuristic

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Caffeine as a probe for CYP1A2 activity: potential influence of renal factors on urinary phenotypic trait measurements

1 reference

https://pubmed.ncbi.nlm.nih.gov/14674790

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Role of cytochrome P4501A2 in chemical carcinogenesis: implications for human variability in expression and enzyme activity.

1 reference

https://pubmed.ncbi.nlm.nih.gov/14674790

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Evaluation of pharmacokinetic methods used to estimate caffeine clearance and comparison with a Bayesian forecasting method

1 reference

https://pubmed.ncbi.nlm.nih.gov/14674790

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Population pharmacokinetics of ciprofloxacin in patients with liver impairments analyzed by NPEM2 algorithm--a retrospective study

1 reference

https://pubmed.ncbi.nlm.nih.gov/14674790

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Phenotyping of CYP1A2 in Japanese population by analysis of caffeine urinary metabolites: absence of mutation prescribing the phenotype in the CYP1A2 gene

1 reference

https://pubmed.ncbi.nlm.nih.gov/14674790

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.2165/00003088-200342150-00006

1 reference

Europe PubMed Central

PubMed publication ID

27 June 2017

Dimensions Publication ID

0 references

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

27 June 2017

ResearchGate publication ID

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