(Q30907499)

English

Induction of granzyme B expression in T-cell receptor/CD28-stimulated human regulatory T cells is suppressed by inhibitors of the PI3K-mTOR pathway

scientific article

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scholarly article

1 reference

Europe PubMed Central

PMC publication ID

14 October 2017

Induction of granzyme B expression in T-cell receptor/CD28-stimulated human regulatory T cells is suppressed by inhibitors of the PI3K-mTOR pathway (English)

1 reference

Europe PubMed Central

PMC publication ID

14 October 2017

author name string

Olga V Efimova

1

1 reference

Europe PubMed Central

PMC publication ID

14 October 2017

Todd W Kelley

2

1 reference

Europe PubMed Central

PMC publication ID

14 October 2017

publication date

22 November 2009

1 reference

Europe PubMed Central

PMC publication ID

14 October 2017

1 reference

Europe PubMed Central

PMC publication ID

14 October 2017

10

1 reference

Europe PubMed Central

PMC publication ID

14 October 2017

59

1 reference

Europe PubMed Central

PMC publication ID

14 October 2017

https://scigraph.springernature.com/pub.10.1186/1471-2172-10-59

0 references

Differential responses of human regulatory T cells (Treg) and effector T cells to rapamycin

1 reference

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28 July 2018

Transplantation survival is maintained by granzyme B+ regulatory cells and adaptive regulatory T cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2784757

28 July 2018

CD28 costimulation is essential for human T regulatory expansion and function

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2784757

28 July 2018

The AKT-mTOR axis regulates de novo differentiation of CD4+Foxp3+ cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2784757

28 July 2018

Differential impact of mammalian target of rapamycin inhibition on CD4+CD25+Foxp3+ regulatory T cells compared with conventional CD4+ T cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2784757

28 July 2018

Adoptive T cell therapy for cancer in the clinic

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2784757

28 July 2018

Natural regulatory T cells: mechanisms of suppression

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2784757

28 July 2018

Induction of granzyme B and T cell cytotoxic capacity by IL-2 or IL-15 without antigens: multiclonal responses that are extremely lytic if triggered and short-lived after cytokine withdrawal

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2784757

28 July 2018

PTEN inhibits IL-2 receptor-mediated expansion of CD4+ CD25+ Tregs

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2784757

28 July 2018

CD127 expression inversely correlates with FoxP3 and suppressive function of human CD4+ T reg cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2784757

28 July 2018

A novel NF-kappaB binding site controls human granzyme B gene transcription

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2784757

28 July 2018

Activated CD4+CD25+ T cells selectively kill B lymphocytes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2784757

28 July 2018

Cutting edge: contact-mediated suppression by CD4+CD25+ regulatory cells involves a granzyme B-dependent, perforin-independent mechanism

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2784757

28 July 2018

Human T regulatory cells can use the perforin pathway to cause autologous target cell death

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2784757

28 July 2018

Distinct IL-2 receptor signaling pattern in CD4+CD25+ regulatory T cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2784757

28 July 2018

Large-scale in vitro expansion of polyclonal human CD4(+)CD25high regulatory T cells.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2784757

28 July 2018

Conversion of peripheral CD4+CD25- naive T cells to CD4+CD25+ regulatory T cells by TGF-beta induction of transcription factor Foxp3

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2784757

28 July 2018

Ulcerative colitis-like disease in mice with a disrupted interleukin-2 gene

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2784757

28 July 2018

Generalized autoimmune disease in interleukin-2-deficient mice is triggered by an uncontrolled activation and proliferation of CD4+ T cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2784757

28 July 2018

In vitro expansion improves in vivo regulation by CD4+CD25+ regulatory T cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2784757

25 November 2018

The influence of immuosuppressive therapy on the development of CD4+CD25+ T cells after renal transplantation.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2784757

25 November 2018

Granzyme B and perforin are important for regulatory T cell-mediated suppression of tumor clearance

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2784757

25 November 2018

TGF-beta1 modulates Foxp3 expression and regulatory activity in distinct CD4+ T cell subsets.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2784757

25 November 2018

IL-2 is essential for TGF-beta to convert naive CD4+CD25- cells to CD25+Foxp3+ regulatory T cells and for expansion of these cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2784757

25 November 2018

Targeting acute allograft rejection by immunotherapy with ex vivo-expanded natural CD4+ CD25+ regulatory T cells.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2784757

25 November 2018

IL-2 receptor beta-dependent STAT5 activation is required for the development of Foxp3+ regulatory T cells.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2784757

25 November 2018

Altered activation of AKT is required for the suppressive function of human CD4+CD25+ T regulatory cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2784757

25 November 2018

Rapamycin does not induce anergy but inhibits expansion and differentiation of alloreactive human T cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2784757

25 November 2018

Transfer of regulatory T cells generated ex vivo modifies graft rejection through induction of tolerogenic CD4+CD25+ cells in the recipient.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2784757

25 November 2018

Rapamycin selectively expands CD4+CD25+FoxP3+ regulatory T cells.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2784757

25 November 2018

Differential expression of granzymes A and B in human cytotoxic lymphocyte subsets and T regulatory cells

1 reference

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Clinical use of rapamycin in renal allograft recipients identifies its relevant toxicity profile and raises unsolved questions: a Single-Center experience

1 reference

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25 November 2018

Alcohol Consumption Decreases IL-2-Induced NF-kappaB Activity in Enriched NK Cells from C57BL/6 Mice

1 reference

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25 November 2018

The potential of human regulatory T cells generated ex vivo as a treatment for lupus and other chronic inflammatory diseases

1 reference

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25 November 2018

Immunologic self-tolerance maintained by CD25+CD4+ naturally anergic and suppressive T cells: induction of autoimmune disease by breaking their anergic/suppressive state

1 reference

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25 November 2018

Ex vivo-expanded natural CD4+CD25+ regulatory T cells synergize with host T-cell depletion to promote long-term survival of allografts

1 reference

https://pubmed.ncbi.nlm.nih.gov/19930596

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Deregulated T cell activation and autoimmunity in mice lacking interleukin-2 receptor beta

1 reference

https://pubmed.ncbi.nlm.nih.gov/19930596

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Calcineurin inhibitors, but not rapamycin, reduce percentages of CD4+CD25+FOXP3+ regulatory T cells in renal transplant recipients

1 reference

https://pubmed.ncbi.nlm.nih.gov/19930596

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

IL-2Rbeta links IL-2R signaling with Foxp3 expression

1 reference

https://pubmed.ncbi.nlm.nih.gov/19930596

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Adoptive transfusion of ex vivo donor alloantigen-stimulated CD4(+)CD25(+) regulatory T cells ameliorates rejection of DA-to-Lewis rat liver transplantation

1 reference

https://pubmed.ncbi.nlm.nih.gov/19930596

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1186/1471-2172-10-59

1 reference

Europe PubMed Central

PMC publication ID

14 October 2017

Dimensions Publication ID

0 references

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

14 October 2017

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

14 October 2017

ResearchGate publication ID

0 references

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