(Q30909300)

27 June 2017

title

Solution structures of cyclic melanocortin agonists and antagonists by NMR. (English)

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27 June 2017

Jinfa Ying

1

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27 June 2017

Katalin E Kövér

2

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27 June 2017

Xuyuan Gu

3

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27 June 2017

Guoxia Han

4

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27 June 2017

Dev B Trivedi

5

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27 June 2017

Malcolm J Kavarana

6

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27 June 2017

Victor J Hruby

7

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27 June 2017

publication date

1 January 2003

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27 June 2017

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27 June 2017

volume

71

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27 June 2017

issue

6

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27 June 2017

page(s)

696-716

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The cloning of a family of genes that encode the melanocortin receptors

27 June 2017

cites work

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Role of melanocortinergic neurons in feeding and the agouti obesity syndrome

21 January 2018

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Targeted disruption of the melanocortin-4 receptor results in obesity in mice

21 January 2018

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Ac-nle-c[asp-his-dphe-arg-trp-lys]-nh2 induces penile erection via brain and spinal melanocortin receptors

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Exocrine gland dysfunction in MC5-R-deficient mice: evidence for coordinated regulation of exocrine gland function by melanocortin peptides

21 January 2018

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4-Norleucine, 7-D-phenylalanine-alpha-melanocyte-stimulating hormone: a highly potent alpha-melanotropin with ultralong biological activity

21 January 2018

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Stereochemical criteria for polypeptides and proteins. V. Conformation of a system of three linked peptide units

21 January 2018

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half-Cys4,half-Cys10-alpha-Melanocyte-stimulating hormone: a cyclic alpha-melanotropin exhibiting superagonist biological activity

21 January 2018

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Cyclic lactam alpha-melanotropin analogues of Ac-Nle4-cyclo[Asp5, D-Phe7,Lys10] alpha-melanocyte-stimulating hormone-(4-10)-NH2 with bulky aromatic amino acids at position 7 show high antagonist potency and selectivity at specific melanocortin recep

21 January 2018

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Novel cyclic templates of alpha-MSH give highly selective and potent antagonists/agonists for human melanocortin-3/4 receptors

21 January 2018

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Modeling of alpha-MSH conformations with implicit solvent.

21 January 2018

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Structure and dynamics of alpha-MSH using DRISM integral equation theory and stochastic dynamics.

21 January 2018

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1H-NMR studies on a potent and selective antagonist at human melanocortin receptor 4 (hMC-4R).

21 January 2018

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Design of a new peptidomimetic agonist for the melanocortin receptors based on the solution structure of the peptide ligand, Ac-Nle-cyclo[Asp-Pro-DPhe-Arg-Trp-Lys]-NH(2).

21 January 2018

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Torsion-angle molecular dynamics as a new efficient tool for NMR structure calculation.

21 January 2018

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Design and pharmacology of N-[(3R)-1,2,3,4-tetrahydroisoquinolinium- 3-ylcarbonyl]-(1R)-1-(4-chlorobenzyl)- 2-[4-cyclohexyl-4-(1H-1,2,4-triazol- 1-ylmethyl)piperidin-1-yl]-2-oxoethylamine (1), a potent, selective, melanocortin subtype-4 receptor ago

21 January 2018

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Simple, distortion-free homonuclear spectra of peptides and nucleic acids in water using excitation sculpting

21 January 2018

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ROESY with water flip back for high-field NMR of biomolecules

21 January 2018

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Application of phase sensitive two-dimensional correlated spectroscopy (COSY) for measurements of 1H-1H spin-spin coupling constants in proteins

21 January 2018

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Automated NOESY interpretation with ambiguous distance restraints: the refined NMR solution structure of the pleckstrin homology domain from beta-spectrin

21 January 2018

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Crystallography & NMR System: A New Software Suite for Macromolecular Structure Determination

21 January 2018

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Floating stereospecific assignment revisited: application to an 18 kDa protein and comparison with J-coupling data

21 January 2018

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Treatment of NOE constraints involving equivalent or nonstereoassigned protons in calculations of biomacromolecular structures

21 January 2018

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Three-dimensional solution structure of Escherichia coli periplasmic cyclophilin

21 January 2018

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Determination of three-dimensional structures of proteins from interproton distance data by hybrid distance geometry-dynamical simulated annealing calculations

21 January 2018

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Sampling and efficiency of metric matrix distance geometry: a novel partial metrization algorithm.

21 January 2018

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Influence of non-bonded parameters on the quality of NMR structures: a new force field for NMR structure calculation

21 January 2018

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VMD: visual molecular dynamics

21 January 2018

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Relationship between nuclear magnetic resonance chemical shift and protein secondary structure

21 January 2018

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The chemical shift index: a fast and simple method for the assignment of protein secondary structure through NMR spectroscopy

21 January 2018

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Peptide/protein structure analysis using the chemical shift index method: upfield alpha-CH values reveal dynamic helices and alpha L sites

21 January 2018

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'Random coil' 1H chemical shifts obtained as a function of temperature and trifluoroethanol concentration for the peptide series GGXGG.

21 January 2018

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Efforts toward deriving the CD spectrum of a 3(10) helix in aqueous medium

21 January 2018

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Analysis of main chain torsion angles in proteins: prediction of NMR coupling constants for native and random coil conformations

21 January 2018

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Determination of three-dimensional structures of proteins and nucleic acids in solution by nuclear magnetic resonance spectroscopy

21 January 2018

1 reference

The solution structure of eglin c based on measurements of many NOEs and coupling constants and its comparison with X‐ray structures

21 January 2018

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Chain reversals in proteins

21 January 2018

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The Protein Data Bank: a computer-based archival file for macromolecular structures

21 January 2018

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Folding of immunogenic peptide fragments of proteins in water solution. I. Sequence requirements for the formation of a reverse turn

21 January 2018

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Structure-activity studies of the melanocortin peptides: discovery of potent and selective affinity antagonists for the hMC3 and hMC4 receptors.

21 January 2018

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Raster3D: photorealistic molecular graphics

21 January 2018

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Turns in peptides and proteins

21 January 2018

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The importance of not saturating water in protein NMR. Application to sensitivity enhancement and NOE measurements

21 January 2018

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Improvement of z Filters and Purging Pulses by the Use of Zero-Quantum Dephasing in Inhomogeneous B1 or B0 Fields

21 January 2018

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Inactivation of the mouse melanocortin-3 receptor results in increased fat mass and reduced lean body mass

21 January 2018

1 reference

alpha-Melanotropin: the minimal active sequence in the frog skin bioassay

21 January 2018

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Alpha-melanotropin: the minimal active sequence in the lizard skin bioassay

21 January 2018

1 reference

Calcium-dependent prolonged effects on melanophores of [4-norleucine, 7-D-phenylalanine]-alpha-melanotropin

21 January 2018

1 reference

Potent and prolonged acting cyclic lactam analogues of alpha-melanotropin: design based on molecular dynamics

21 January 2018

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D-isomeric replacements within the 6-9 core sequence of Ac-[Nle4]-alpha-MSH4-11-NH2: a topological model for the solution conformation of alpha-melanotropin

21 January 2018

1 reference

Cyclic lactam analogues of Ac-[Nle4]alpha-MSH4-11-NH2

21 January 2018

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The space structures of α-melanotropin

21 January 2018

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Possible bioactive conformations of alpha-melanotropin

21 January 2018

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Solution structures of the melanocyte-stimulating hormones by two-dimensional NMR spectroscopy and dynamical simulated-annealing calculations

21 January 2018

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Type I beta-turn conformation is important for biological activity of the melanocyte-stimulating hormone analogues

21 January 2018

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Analysis of two-residue turns in proteins

21 January 2018

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Analogs of MTII, lactam derivatives of alpha-melanotropin, modified at the N-terminus, and their selectivity at human melanocortin receptors 3, 4, and 5

21 January 2018

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Gradient- and sensitivity-enhanced TOCSY experiments

21 January 2018

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Determining stereo-specific 1H nuclear magnetic resonance assignments from distance geometry calculations

21 January 2018

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Stereochemically restrained refinement of macromolecular structures

21 January 2018

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Amide proton temperature coefficients as hydrogen bond indicators in proteins

21 January 2018

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Hydrogen bonds in human ubiquitin reflected in temperature coefficients of amide protons

21 January 2018

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Nuclear magnetic resonance identification of "half-turn" and 3(10)-helix secondary structure in rabbit liver metallothionein-2

21 January 2018

1 reference

21 January 2018

Identifiers

DOI

10.1002/BIP.10596

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27 June 2017

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