(Q30936725)

English

Comparison of the use of liver models for predicting drug clearance using in vitro kinetic data from hepatic microsomes and isolated hepatocytes

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scholarly article

1 reference

Europe PubMed Central

PubMed publication ID

27 June 2017

Comparison of the use of liver models for predicting drug clearance using in vitro kinetic data from hepatic microsomes and isolated hepatocytes (English)

1 reference

Europe PubMed Central

PubMed publication ID

27 June 2017

author name string

Kiyomi Ito

1

1 reference

Europe PubMed Central

PubMed publication ID

27 June 2017

J Brian Houston

2

1 reference

Europe PubMed Central

PubMed publication ID

27 June 2017

publication date

1 May 2004

1 reference

Europe PubMed Central

PubMed publication ID

27 June 2017

Pharmaceutical Research

1 reference

Europe PubMed Central

PubMed publication ID

27 June 2017

21

1 reference

Europe PubMed Central

PubMed publication ID

27 June 2017

5

1 reference

Europe PubMed Central

PubMed publication ID

27 June 2017

785-792

1 reference

Europe PubMed Central

PubMed publication ID

27 June 2017

Sigmoidal kinetics of CYP3A substrates: an approach for scaling dextromethorphan metabolism in hepatic microsomes and isolated hepatocytes to predict in vivo clearance in rat

1 reference

https://pubmed.ncbi.nlm.nih.gov/15180335

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Determination of hepatic blood flow in the rat using sequential infusions of indocyanine green or galactose

1 reference

https://pubmed.ncbi.nlm.nih.gov/15180335

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Regional drug delivery II: relationship between drug targeting index and pharmacokinetic parameters for three non-steroidal anti-inflammatory drugs using the rat air pouch model of inflammation.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15180335

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Kinetics of drug metabolism in rat liver slices: IV. Comparison of ethoxycoumarin clearance by liver slices, isolated hepatocytes, and hepatic microsomes from rats pretreated with known modifiers of cytochrome P-450 activity

1 reference

https://pubmed.ncbi.nlm.nih.gov/15180335

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Prediction of human clearance of twenty-nine drugs from hepatic microsomal intrinsic clearance data: An examination of in vitro half-life approach and nonspecific binding to microsomes.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15180335

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Induction of propranolol metabolism by the azo dye sudan III in rats

1 reference

https://pubmed.ncbi.nlm.nih.gov/15180335

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Scaling factors to relate drug metabolic clearance in hepatic microsomes, isolated hepatocytes, and the intact liver: studies with induced livers involving diazepam.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15180335

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Role of pharmacokinetics and metabolism in drug discovery and development

1 reference

https://pubmed.ncbi.nlm.nih.gov/15180335

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Utility of in vitro drug metabolism data in predicting in vivo metabolic clearance

1 reference

https://pubmed.ncbi.nlm.nih.gov/15180335

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Complications in the estimation of hepatic blood flow in vivo by pharmacokinetic parameters. The area under the curve after the concomitant intravenous and intraperitoneal (or intraportal) administration of acetaminophen in the rat

1 reference

https://pubmed.ncbi.nlm.nih.gov/15180335

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Some suggestions for measuring predictive performance

1 reference

https://pubmed.ncbi.nlm.nih.gov/15180335

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Correlation between in-vitro microsomal enzyme activity and whole organ hepatic elimination kinetics: analysis with a dispersion model

1 reference

https://pubmed.ncbi.nlm.nih.gov/15180335

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The prediction of human pharmacokinetic parameters from preclinical and in vitro metabolism data.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15180335

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Species differences in the metabolism of a potent HIV-1 reverse transcriptase inhibitor L-738,372. In vivo and in vitro studies in rats, dogs, monkeys, and human

1 reference

https://pubmed.ncbi.nlm.nih.gov/15180335

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Disposition of azole antifungal agents. I. Nonlinearities in ketoconazole clearance and binding in rat liver

1 reference

https://pubmed.ncbi.nlm.nih.gov/15180335

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Species differences in the pharmacokinetics and metabolism of indinavir, a potent human immunodeficiency virus protease inhibitor.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15180335

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Prediction of species differences (rats, dogs, humans) in the in vivo metabolic clearance of YM796 by the liver from in vitro data.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15180335

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Comparison of the hepatic uptake clearances of fifteen drugs with a wide range of membrane permeabilities in isolated rat hepatocytes and perfused rat livers

1 reference

https://pubmed.ncbi.nlm.nih.gov/15180335

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A carrier-protein receptor is not a prerequisite for avid hepatic elimination of highly bound compounds: a study of propranolol elimination by the isolated perfused rat liver

1 reference

https://pubmed.ncbi.nlm.nih.gov/15180335

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Prediction of hepatic clearance from microsomes, hepatocytes, and liver slices

1 reference

https://pubmed.ncbi.nlm.nih.gov/15180335

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Hepatic and intestinal metabolism of indinavir, an HIV protease inhibitor, in rat and human microsomes. Major role of CYP3A

1 reference

https://pubmed.ncbi.nlm.nih.gov/15180335

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Prediction of human hepatic clearance from in vivo animal experiments and in vitro metabolic studies with liver microsomes from animals and humans.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15180335

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Integration of in vitro data into allometric scaling to predict hepatic metabolic clearance in man: application to 10 extensively metabolized drugs

1 reference

https://pubmed.ncbi.nlm.nih.gov/15180335

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1023/B:PHAM.0000026429.12114.7D

1 reference

Europe PubMed Central

PubMed publication ID

27 June 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

27 June 2017

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