(Q30956877)

27 June 2017

The amino terminus targets the mixed lineage leukemia (MLL) protein to the nucleolus, nuclear matrix and mitotic chromosomal scaffolds (English)

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27 June 2017

Caslini C

1

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27 June 2017

Alarcòn AS

2

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27 June 2017

Hess JL

3

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27 June 2017

Tanaka R

4

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27 June 2017

Murti KG

5

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27 June 2017

Biondi A

6

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27 June 2017

1 November 2000

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27 June 2017

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27 June 2017

14

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27 June 2017

11

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27 June 2017

1898-1908

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The mixed lineage leukemia (MLL) protein involved in 11q23 translocations contains a domain that binds cruciform DNA and scaffold attachment region (SAR) DNA.

27 June 2017

1 reference

12 December 2020

Human acute leukemia cell line with the t(4;11) chromosomal rearrangement exhibits B lineage and monocytic characteristics.

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12 December 2020

Chimeric MLL products with a Ras binding cytoplasmic protein AF6 involved in t(6;11) (q27;q23) leukemia localize in the nucleus

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12 December 2020

Localization of topoisomerase II in mitotic chromosomes

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12 December 2020

Chromosomal translocations in benign tumors: the HMGI proteins

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12 December 2020

Rearrangement of the MLL gene in acute lymphoblastic and acute myeloid leukemias with 11q23 chromosomal translocations

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12 December 2020

Analysis of the murine All-1 gene reveals conserved domains with human ALL-1 and identifies a motif shared with DNA methyltransferases

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12 December 2020

A serine/proline-rich protein is fused to HRX in t(4;11) acute leukemias

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12 December 2020

Localization of adenovirus-encoded DNA replication proteins in the nucleus by immunogold electron microscopy

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12 December 2020

11q23 translocations split the "AT-hook" cruciform DNA-binding region and the transcriptional repression domain from the activation domain of the mixed-lineage leukemia (MLL) gene

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12 December 2020

Metaphase chromosome structure. Involvement of topoisomerase II

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12 December 2020

Altered Hox expression and segmental identity in Mll-mutant mice

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12 December 2020

The Drosophila trithorax protein binds to specific chromosomal sites and is co-localized with Polycomb at many sites

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12 December 2020

Transformation of axial skeleton due to overexpression of bmi-1 in transgenic mice

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12 December 2020

SARs are cis DNA elements of chromosome dynamics: synthesis of a SAR repressor protein.

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12 December 2020

The A.T-DNA-binding domain of mammalian high mobility group I chromosomal proteins. A novel peptide motif for recognizing DNA structure

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12 December 2020

Involvement of a homolog of Drosophila trithorax by 11q23 chromosomal translocations in acute leukemias

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12 December 2020

DNA methyltransferase Dnmt1 associates with histone deacetylase activity

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12 December 2020

The leukemia-associated-protein (LAP) domain, a cysteine-rich motif, is present in a wide range of proteins, including MLL, AF10, and MLLT6 proteins

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12 December 2020

Identification of MLL and chimeric MLL gene products involved in 11q23 translocation and possible mechanisms of leukemogenesis by MLL truncation.

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12 December 2020

The trithorax gene, a trans-acting regulator of the bithorax complex in Drosophila, encodes a protein with zinc-binding domains

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12 December 2020

Preferential, cooperative binding of DNA topoisomerase II to scaffold-associated regions

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12 December 2020

AF4 encodes a ubiquitous protein that in both native and MLL-AF4 fusion types localizes to subnuclear compartments

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12 December 2020

Identification of Bmi1-interacting proteins as constituents of a multimeric mammalian polycomb complex

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12 December 2020

A human acute lymphoblastic leukemia line with the T(4;11) translocation as a model of minimal residual disease in SCID mice

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12 December 2020

Scaffold-associated regions: cis-acting determinants of chromatin structural loops and functional domains

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12 December 2020

Nuclear punctate distribution of ALL-1 is conferred by distinct elements at the N terminus of the protein

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12 December 2020

Truncated and chimeric HMGI-C genes induce neoplastic transformation of NIH3T3 murine fibroblasts

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12 December 2020

Sequence analysis of the breakpoint cluster region in the ALL-1 gene involved in acute leukemia.

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12 December 2020

Childhood acute lymphoblastic leukemia with chromosomal breakpoints at 11q23.

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12 December 2020

Metaphase chromosome structure: bands arise from a differential folding path of the highly AT-rich scaffold

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12 December 2020

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12 December 2020

Tight control of gene expression in mammalian cells by tetracycline-responsive promoters

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12 December 2020

The Drosophila trithorax gene encodes a chromosomal protein and directly regulates the region-specific homeotic gene fork head.

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12 December 2020

Acute mixed-lineage leukemia t(4;11)(q21;q23) generates an MLL-AF4 fusion product

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12 December 2020

Identification of a gene, MLL, that spans the breakpoint in 11q23 translocations associated with human leukemias

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12 December 2020

An Mll-AF9 fusion gene made by homologous recombination causes acute leukemia in chimeric mice: a method to create fusion oncogenes

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12 December 2020

Detection of ALL-1/AF4 fusion transcript by reverse transcription-polymerase chain reaction for diagnosis and monitoring of acute leukemias with the t(4;11) translocation

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12 December 2020

A trithorax-like gene is interrupted by chromosome 11q23 translocations in acute leukaemias

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12 December 2020

The oncogenic capacity of HRX-ENL requires the transcriptional transactivation activity of ENL and the DNA binding motifs of HRX.

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12 December 2020

Topoisomerase II is a structural component of mitotic chromosome scaffolds.

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12 December 2020

The HRX proto-oncogene product is widely expressed in human tissues and localizes to nuclear structures

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12 December 2020

The Drosophila Polycomb-group gene Enhancer of zeste contains a region with sequence similarity to trithorax

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12 December 2020

Core filaments of the nuclear matrix

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12 December 2020

The t(4;11) chromosome translocation of human acute leukemias fuses the ALL-1 gene, related to Drosophila trithorax, to the AF-4 gene

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12 December 2020

The human ALL-1/MLL/HRX antigen is predominantly localized in the nucleus of resting and proliferating peripheral blood mononuclear cells.

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12 December 2020

Secondary acute myeloid leukemia in children treated for acute lymphoid leukemia

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12 December 2020

Disruption of the architectural factor HMGI-C: DNA-binding AT hook motifs fused in lipomas to distinct transcriptional regulatory domains

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12 December 2020

Mammalian Trithorax and polycomb-group homologues are antagonistic regulators of homeotic development

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12 December 2020

Recurrent rearrangements in the high mobility group protein gene, HMGI-C, in benign mesenchymal tumours

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12 December 2020

Protein kinase C associates with intermediate filaments and stress fibers

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12 December 2020

ALL-1 partial duplication in acute leukemia

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12 December 2020

Propagating memory of transcriptional states

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12 December 2020

Studies on scaffold attachment sites and their relation to genome function

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12 December 2020

A component of the transcriptional repressor MeCP1 shares a motif with DNA methyltransferase and HRX proteins

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12 December 2020

Cloning of ALL-1, the locus involved in leukemias with the t(4;11)(q21;q23), t(9;11)(p22;q23), and t(11;19)(q23;p13) chromosome translocations

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12 December 2020

Domains with transcriptional regulatory activity within the ALL1 and AF4 proteins involved in acute leukemia

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12 December 2020

AT-hook motifs identified in a wide variety of DNA-binding proteins

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12 December 2020

MLLT3 gene on 9p22 involved in t(9;11) leukemia encodes a serine/proline rich protein homologous to MLLT1 on 19p13.

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12 December 2020

Nuclear matrix. Isolation and characterization of a framework structure from rat liver nuclei

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12 December 2020

The structure of histone-depleted metaphase chromosomes

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12 December 2020

The PHD finger: implications for chromatin-mediated transcriptional regulation

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12 December 2020

Transcriptional silencing of homeotic genes in Drosophila

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12 December 2020

Cytogenetics of childhood acute nonlymphocytic leukemia

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12 December 2020

The amino terminus of the mixed lineage leukemia protein (MLL) promotes cell cycle arrest and monocytic differentiation

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12 December 2020

Tumorigenesis in mice with a fusion of the leukaemia oncogene Mll and the bacterial lacZ gene.

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12 December 2020

Identifiers

DOI

10.1038/SJ.LEU.2401933

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Dimensions Publication ID

27 June 2017

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