(Q31016741)

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Simultaneous blockade of both the epidermal growth factor receptor and the insulin-like growth factor receptor signaling pathways in cancer cells with a fully human recombinant bispecific antibody.

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20 December 2019

Simultaneous blockade of both the epidermal growth factor receptor and the insulin-like growth factor receptor signaling pathways in cancer cells with a fully human recombinant bispecific antibody (English)

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:14576153%20AND%20SRC:MED&resulttype=core&format=json

20 December 2019

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20 December 2019

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Dan Lu

1

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20 December 2019

Haifan Zhang

2

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20 December 2019

Dale Ludwig

3

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20 December 2019

Anita Persaud

4

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20 December 2019

Xenia Jimenez

5

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20 December 2019

Douglas Burtrum

6

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20 December 2019

Paul Balderes

7

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20 December 2019

Peter Bohlen

9

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20 December 2019

Larry Witte

10

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20 December 2019

Zhenping Zhu

11

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20 December 2019

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23 October 2003

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20 December 2019

Journal of Biological Chemistry

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20 December 2019

279

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20 December 2019

4

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20 December 2019

2856-2865

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20 December 2019

Clinical trials of antibody therapy

1 reference

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The insulin-like growth factor-I receptor signaling pathways are important for tumorigenesis and inhibition of apoptosis

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Overview of epidermal growth factor receptor biology and its role as a therapeutic target in human neoplasia

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The EGFR family and its ligands in human cancer. signalling mechanisms and therapeutic opportunities

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21 January 2018

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Role of an anti-epidermal growth factor receptor in treating cancer

1 reference

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21 January 2018

Status of epidermal growth factor receptor antagonists in the biology and treatment of cancer

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21 January 2018

Targeting epidermal growth factor receptor: novel therapeutics in the management of cancer

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21 January 2018

Insulin-like growth factor receptor-1 as an anti-cancer target: blocking transformation and inducing apoptosis

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21 January 2018

Immunotherapeutic perspective for bispecific antibodies

1 reference

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21 January 2018

A large non-immunized human Fab fragment phage library that permits rapid isolation and kinetic analysis of high affinity antibodies

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21 January 2018

Selection of high affinity human neutralizing antibodies to VEGFR2 from a large antibody phage display library for antiangiogenesis therapy

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21 January 2018

Tailoring in vitro selection for a picomolar affinity human antibody directed against vascular endothelial growth factor receptor 2 for enhanced neutralizing activity

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21 January 2018

High-level expression of a recombinant antibody from myeloma cells using a glutamine synthetase gene as an amplifiable selectable marker

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21 January 2018

Di-diabody: a novel tetravalent bispecific antibody molecule by design

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21 January 2018

Regulation of survival signals from the insulin-like growth factor-I receptor

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21 January 2018

Insulin-like growth factor (IGF)-I rescues breast cancer cells from chemotherapy-induced cell death--proliferative and anti-apoptotic effects

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21 January 2018

Insulin-like growth factor-I receptor signaling and resistance to trastuzumab (Herceptin).

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21 January 2018

Expression of receptors for epidermal growth factor and insulin-like growth factor I by ZR-75-1 human breast cancer cell variants is inversely related: the effect of steroid hormones on insulin-like growth factor I receptor expression

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21 January 2018

The anti-proliferative effect of suramin towards tamoxifen-sensitive and resistant human breast cancer cell lines in relation to expression of receptors for epidermal growth factor and insulin-like growth factor-I: growth stimulation in the presence

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New protein engineering approaches to multivalent and bispecific antibody fragments

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21 January 2018

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21 January 2018

An efficient route to human bispecific IgG.

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Novel tetravalent and bispecific IgG-like antibody molecules combining single-chain diabodies with the immunoglobulin gamma1 Fc or CH3 region

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Design and production of novel tetravalent bispecific antibodies

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Engineering high affinity humanized anti‐p185HER2/anti‐CD3 bispecific F(ab′)2 for efficient lysis of p185HER2 overexpressing tumor cells

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21 January 2018

"Diabodies": small bivalent and bispecific antibody fragments

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21 January 2018

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Identifiers

10.1074/JBC.M310132200

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:14576153%20AND%20SRC:MED&resulttype=core&format=json

20 December 2019

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:14576153%20AND%20SRC:MED&resulttype=core&format=json

20 December 2019

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