(Q31051979)

English

Unexpected novel binding mode of pyrrolidine-based aspartyl protease inhibitors: design, synthesis and crystal structure in complex with HIV protease

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scholarly article

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Europe PubMed Central

28 June 2017

Unexpected novel binding mode of pyrrolidine-based aspartyl protease inhibitors: design, synthesis and crystal structure in complex with HIV protease (English)

1 reference

Europe PubMed Central

28 June 2017

crystal structure

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author name string

Edgar Specker

1

1 reference

Europe PubMed Central

28 June 2017

Jark Böttcher

2

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Europe PubMed Central

28 June 2017

Sascha Brass

3

1 reference

Europe PubMed Central

28 June 2017

Andreas Heine

4

1 reference

Europe PubMed Central

28 June 2017

Hauke Lilie

5

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Europe PubMed Central

28 June 2017

Andreas Schoop

6

1 reference

Europe PubMed Central

28 June 2017

Gerhard Müller

7

1 reference

Europe PubMed Central

28 June 2017

Nils Griebenow

8

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Europe PubMed Central

28 June 2017

Gerhard Klebe

9

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Europe PubMed Central

28 June 2017

publication date

1 January 2006

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Europe PubMed Central

28 June 2017

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Europe PubMed Central

28 June 2017

1

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Europe PubMed Central

28 June 2017

1

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28 June 2017

106-117

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28 June 2017

Protease inhibitors: current status and future prospects

1 reference

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Pepstatin-derived inhibitors of aspartic proteinases. A close look at an apparent transition-state analogue inhibitor

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Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings

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Three-dimensional structure of aspartyl protease from human immunodeficiency virus HIV-1

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Conserved folding in retroviral proteases: crystal structure of a synthetic HIV-1 protease

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7 January 2021

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5,6-Dihydropyran-2-ones possessing various sulfonyl functionalities: potent nonpeptidic inhibitors of HIV protease

1 reference

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Designing non-peptide peptidomimetics in the 21st century: inhibitors targeting conformational ensembles.

1 reference

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Development and significance of resistance to protease inhibitors in HIV-1-infected adults under triple-drug therapy in clinical practice

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Substituted piperidines--highly potent renin inhibitors due to induced fit adaptation of the active site

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Piperidine-renin inhibitors compounds with improved physicochemical properties

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Multidrug Resistance to HIV-1 Protease Inhibition Requires Cooperative Coupling between Distal Mutations

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X-ray structure of plasmepsin II complexed with a potent achiral inhibitor

1 reference

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Crystal structures of native and inhibited forms of human cathepsin D: implications for lysosomal targeting and drug design

1 reference

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Structure of the dimethyl sulfoxide-oxalyl chloride reaction product. Oxidation of heteroaromatic and diverse alcohols to carbonyl compounds

1 reference

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Reductive Amination of Aldehydes and Ketones with Sodium Triacetoxyborohydride. Studies on Direct and Indirect Reductive Amination Procedures(1).

1 reference

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A simple, continuous fluorometric assay for HIV protease

1 reference

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Design of sensitive fluorogenic substrates for human cathepsin D

1 reference

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7 January 2021

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Knowledge-based scoring function to predict protein-ligand interactions.

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Automated docking of flexible ligands: applications of AutoDock

1 reference

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Automated docking using a Lamarckian genetic algorithm and an empirical binding free energy function

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Docking into knowledge-based potential fields: a comparative evaluation of DrugScore

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7 January 2021

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A new method to detect related function among proteins independent of sequence and fold homology.

1 reference

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From Structure to Function: A New Approach to Detect Functional Similarity among Proteins Independent from Sequence and Fold Homology

1 reference

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7 January 2021

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An old target revisited: two new privileged skeletons and an unexpected binding mode for HIV-protease inhibitors

1 reference

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7 January 2021

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High-level expression and purification of mature HIV-1 protease in Escherichia coli under control of the araBAD promoter

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7 January 2021

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Processing of X-ray diffraction data collected in oscillation mode

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7 January 2021

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AMoRe: an automated package for molecular replacement

1 reference

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7 January 2021

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Molecular recognition of macrocyclic peptidomimetic inhibitors by HIV-1 protease

1 reference

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7 January 2021

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Improved methods for building protein models in electron density maps and the location of errors in these models

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200500008

7 January 2021

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Unexpected binding mode of a cyclic sulfamide HIV-1 protease inhibitor

1 reference

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7 January 2021

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Statistical potentials for fold assessment.

1 reference

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7 January 2021

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Regioselective structural and functional mimicry of peptides. Design of hydrolytically-stable cyclic peptidomimetic inhibitors of HIV-1 protease

1 reference

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7 January 2021

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Three-dimensional structures of HIV-1 and SIV protease product complexes

1 reference

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Substrate-Based Cyclic Peptidomimetics of Phe-Ile-Val That Inhibit HIV-1 Protease Using a Novel Enzyme-Binding Mode

1 reference

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7 January 2021

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Structural and kinetic analysis of drug resistant mutants of HIV-1 protease

1 reference

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7 January 2021

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Synthesis and comparative molecular field analysis (CoMFA) of symmetric and nonsymmetric cyclic sulfamide HIV-1 protease inhibitors

1 reference

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7 January 2021

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Structural implications of drug-resistant mutants of HIV-1 protease: high-resolution crystal structures of the mutant protease/substrate analogue complexes

1 reference

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Structure of complex of synthetic HIV-1 protease with a substrate-based inhibitor at 2.3 A resolution

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Identifiers

10.1002/CMDC.200500008

1 reference

Europe PubMed Central

28 June 2017

1 reference

Europe PubMed Central

28 June 2017

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