Home
Random
Nearby
Log in
Settings
Donate
About Wikidata
Disclaimers
Search
(Q31425913)
Watch
English
The cystine knot motif in toxins and implications for drug design.
scientific article
In more languages
edit
Statements
instance of
scholarly article
1 reference
stated in
Europe PubMed Central
PubMed ID
10936622
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10936622%20AND%20SRC:MED&resulttype=core&format=json
retrieved
9 November 2019
review article
1 reference
stated in
Europe PubMed Central
title
The cystine knot motif in toxins and implications for drug design
(English)
1 reference
stated in
Europe PubMed Central
PubMed ID
10936622
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10936622%20AND%20SRC:MED&resulttype=core&format=json
retrieved
9 November 2019
author
David Craik
series ordinal
1
1 reference
stated in
Europe PubMed Central
PubMed ID
10936622
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10936622%20AND%20SRC:MED&resulttype=core&format=json
retrieved
9 November 2019
Norelle L Daly
series ordinal
2
1 reference
stated in
Europe PubMed Central
PubMed ID
10936622
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10936622%20AND%20SRC:MED&resulttype=core&format=json
retrieved
9 November 2019
author name string
C Waine
series ordinal
3
1 reference
stated in
Europe PubMed Central
PubMed ID
10936622
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10936622%20AND%20SRC:MED&resulttype=core&format=json
retrieved
9 November 2019
publication date
1 January 2001
1 reference
stated in
Europe PubMed Central
PubMed ID
10936622
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10936622%20AND%20SRC:MED&resulttype=core&format=json
retrieved
9 November 2019
number of pages
18
1 reference
based on heuristic
inferred from page(s)
published in
Toxicon
1 reference
stated in
Europe PubMed Central
PubMed ID
10936622
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10936622%20AND%20SRC:MED&resulttype=core&format=json
retrieved
9 November 2019
volume
39
1 reference
stated in
Europe PubMed Central
PubMed ID
10936622
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10936622%20AND%20SRC:MED&resulttype=core&format=json
retrieved
9 November 2019
page(s)
43-60
1 reference
stated in
Europe PubMed Central
PubMed ID
10936622
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10936622%20AND%20SRC:MED&resulttype=core&format=json
retrieved
9 November 2019
issue
1
1 reference
stated in
Europe PubMed Central
PubMed ID
10936622
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10936622%20AND%20SRC:MED&resulttype=core&format=json
retrieved
9 November 2019
cites work
Disulfide bonding patterns and protein topologies
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0041-0101%2800%2900160-4
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The underlying mechanism for the diversity of disulfide folding pathways
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0041-0101%2800%2900160-4
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Use of restrained molecular dynamics in water to determine three-dimensional protein structure: prediction of the three-dimensional structure of Ecballium elaterium trypsin inhibitor II
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0041-0101%2800%2900160-4
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Solution conformation of a synthetic bis-headed inhibitor of trypsin and carboxypeptidase A: new structural alignment between the squash inhibitors and the potato carboxypeptidase inhibitor
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0041-0101%2800%2900160-4
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The cystine knot of a squash-type protease inhibitor as a structural scaffold for Escherichia coli cell surface display of conformationally constrained peptides
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0041-0101%2800%2900160-4
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Fractionation Protocol for the Isolation of Polypeptides from Plant Biomass
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0041-0101%2800%2900160-4
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Plant cyclotides: A unique family of cyclic and knotted proteins that defines the cyclic cystine knot structural motif
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0041-0101%2800%2900160-4
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Acyclic permutants of naturally occurring cyclic proteins. Characterization of cystine knot and beta-sheet formation in the macrocyclic polypeptide kalata B1.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0041-0101%2800%2900160-4
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Solution structure by NMR of circulin A: a macrocyclic knotted peptide having anti-HIV activity
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0041-0101%2800%2900160-4
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Chemical synthesis and folding pathways of large cyclic polypeptides: studies of the cystine knot polypeptide kalata B1.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0041-0101%2800%2900160-4
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
A novel endogenous inhibitor of phenoloxidase from Musca domestica has a cystine motif commonly found in snail and spider toxins.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0041-0101%2800%2900160-4
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
RhNGF slow unfolding is not due to proline isomerization: possibility of a cystine knot loop-threading mechanism
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0041-0101%2800%2900160-4
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Solution structure of omega-conotoxin MVIIC, a high affinity ligand of P-type calcium channels, using 1H NMR spectroscopy and complete relaxation matrix analysis
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0041-0101%2800%2900160-4
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The structure of versutoxin (delta-atracotoxin-Hv1) provides insights into the binding of site 3 neurotoxins to the voltage-gated sodium channel
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0041-0101%2800%2900160-4
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
High-resolution solution structure of gurmarin, a sweet-taste-suppressing plant polypeptide
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0041-0101%2800%2900160-4
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The structure of a novel insecticidal neurotoxin, omega-atracotoxin-HV1, from the venom of an Australian funnel web spider
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0041-0101%2800%2900160-4
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Role of disulfide bridges in the folding, structure and biological activity of omega-conotoxin GVIA.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0041-0101%2800%2900160-4
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Seven novel macrocyclic polypeptides from Viola arvensis
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0041-0101%2800%2900160-4
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
New circulin macrocyclic polypeptides from Chassalia parvifolia
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0041-0101%2800%2900160-4
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Cycloviolins A-D, anti-HIV macrocyclic peptides from Leonia cymosa
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0041-0101%2800%2900160-4
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The disulphide beta-cross: from cystine geometry and clustering to classification of small disulphide-rich protein folds
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0041-0101%2800%2900160-4
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Three-dimensional solution structure of mu-conotoxin GIIIB, a specific blocker of skeletal muscle sodium channels
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0041-0101%2800%2900160-4
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Solution structure of the sodium channel antagonist conotoxin GS: a new molecular caliper for probing sodium channel geometry
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0041-0101%2800%2900160-4
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Cystine knots
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0041-0101%2800%2900160-4
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Three-dimensional solution structure of the calcium channel antagonist omega-agatoxin IVA: consensus molecular folding of calcium channel blockers
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0041-0101%2800%2900160-4
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
MOLMOL: a program for display and analysis of macromolecular structures
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0041-0101%2800%2900160-4
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Molecular recognition between serine proteases and new bioactive microproteins with a knotted structure
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0041-0101%2800%2900160-4
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Characterization and 2D NMR study of the stable [9-21, 15-27] 2 disulfide intermediate in the folding of the 3 disulfide trypsin inhibitor EETI II.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0041-0101%2800%2900160-4
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Solid phase synthesis of a trypsin inhibitor isolated from the Cucurbitaceae Ecballium elaterium.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0041-0101%2800%2900160-4
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Solution structure of the major alpha-amylase inhibitor of the crop plant amaranth
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0041-0101%2800%2900160-4
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Are there knots in proteins?
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0041-0101%2800%2900160-4
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Topological chirality of proteins
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0041-0101%2800%2900160-4
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
A structural superfamily of growth factors containing a cystine knot motif
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0041-0101%2800%2900160-4
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Antagonists of neuronal calcium channels: structure, function, and therapeutic implications
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0041-0101%2800%2900160-4
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Topological similarities in TGF-beta 2, PDGF-BB and NGF define a superfamily of polypeptide growth factors
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0041-0101%2800%2900160-4
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Snail and spider toxins share a similar tertiary structure and 'cystine motif'
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0041-0101%2800%2900160-4
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Structure-activity relationships of omega-conotoxins MVIIA, MVIIC and 14 loop splice hybrids at N and P/Q-type calcium channels
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0041-0101%2800%2900160-4
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
A consensus structure for omega-conotoxins with different selectivities for voltage-sensitive calcium channel subtypes: comparison of MVIIA, SVIB and SNX-202
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0041-0101%2800%2900160-4
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The cystine knot structure of ion channel toxins and related polypeptides
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0041-0101%2800%2900160-4
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Diversity of Conus neuropeptides
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0041-0101%2800%2900160-4
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Three-dimensional structure analysis of mu-agatoxins: further evidence for common motifs among neurotoxins with diverse ion channel specificities
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0041-0101%2800%2900160-4
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Refined solution structure of omega-conotoxin GVIA: implications for calcium channel binding
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0041-0101%2800%2900160-4
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Solution structure of robustoxin, the lethal neurotoxin from the funnel-web spider Atrax robustus
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0041-0101%2800%2900160-4
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
A common structural motif incorporating a cystine knot and a triple-stranded beta-sheet in toxic and inhibitory polypeptides
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0041-0101%2800%2900160-4
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Folding of omega-conotoxins. 2. Influence of precursor sequences and protein disulfide isomerase.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0041-0101%2800%2900160-4
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Roles of individual disulfide bonds in the stability and folding of an omega-conotoxin.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0041-0101%2800%2900160-4
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Proton nuclear magnetic resonance studies on huwentoxin-I from the venom of the spider Selenocosmia huwena: 2. Three-dimensional structure in solution
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0041-0101%2800%2900160-4
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Refined crystal structure of the potato inhibitor complex of carboxypeptidase A at 2.5 A resolution
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0041-0101%2800%2900160-4
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The solution structure of omega-Aga-IVB, a P-type calcium channel antagonist from venom of the funnel web spider, Agelenopsis aperta
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0041-0101%2800%2900160-4
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Elucidation of the primary and three-dimensional structure of the uterotonic polypeptide kalata B1
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0041-0101%2800%2900160-4
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Solution structure and proposed binding mechanism of a novel potassium channel toxin kappa-conotoxin PVIIA
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0041-0101%2800%2900160-4
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Small binding proteins selected from a combinatorial repertoire of knottins displayed on phage
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0041-0101%2800%2900160-4
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
A biomimetic strategy in the synthesis and fragmentation of cyclic protein
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0041-0101%2800%2900160-4
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
An unusual structural motif of antimicrobial peptides containing end-to-end macrocycle and cystine-knot disulfides
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0041-0101%2800%2900160-4
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Folding motifs induced and stabilized by distinct cystine frameworks.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0041-0101%2800%2900160-4
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
A cyclic antimicrobial peptide produced in primate leukocytes by the ligation of two truncated alpha-defensins
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0041-0101%2800%2900160-4
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The race-specific elicitor AVR9 of the tomato pathogen Cladosporium fulvum: a cystine knot protein. Sequence-specific 1H NMR assignments, secondary structure and global fold of the protein
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0041-0101%2800%2900160-4
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Sequence requirements of the GPNG beta-turn of the Ecballium elaterium trypsin inhibitor II explored by combinatorial library screening
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0041-0101%2800%2900160-4
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Cyclopsychotride A, a biologically active, 31-residue cyclic peptide isolated from Psychotria longipes
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0041-0101%2800%2900160-4
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Three-dimensional structure of Selenocosmia huwena lectin-I (SHL-I) from the venom of the spider Selenocosmia huwena by 2D-NMR
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0041-0101%2800%2900160-4
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Identifiers
DOI
10.1016/S0041-0101(00)00160-4
1 reference
stated in
Europe PubMed Central
PubMed ID
10936622
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10936622%20AND%20SRC:MED&resulttype=core&format=json
retrieved
9 November 2019
PubMed ID
10936622
1 reference
stated in
Europe PubMed Central
PubMed ID
10936622
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10936622%20AND%20SRC:MED&resulttype=core&format=json
retrieved
9 November 2019
Sitelinks
Wikipedia
(0 entries)
edit
Wikibooks
(0 entries)
edit
Wikinews
(0 entries)
edit
Wikiquote
(0 entries)
edit
Wikisource
(0 entries)
edit
Wikiversity
(0 entries)
edit
Wikivoyage
(0 entries)
edit
Wiktionary
(0 entries)
edit
Multilingual sites
(0 entries)
edit