(Q31860392)

4 July 2017

Inhibition of stimulated Jurkat cell adenosine 3',5'-cyclic monophosphate synthesis by the immunomodulatory compound HR325. (English)

1 reference

4 July 2017

Curnock AP

1

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4 July 2017

Thomson TA

2

1 reference

4 July 2017

Westwood R

3

1 reference

4 July 2017

Kuo EA

4

1 reference

4 July 2017

Williamson RA

5

1 reference

4 July 2017

Yea CM

6

1 reference

4 July 2017

Ruuthb E

7

1 reference

4 July 2017

language of work or name

English

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publication date

1 January 2001

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4 July 2017

Biochemical Pharmacology

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4 July 2017

61

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4 July 2017

227-235

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4 July 2017

2

1 reference

Dihydroorotate dehydrogenase is a high affinity binding protein for A77 1726 and mediator of a range of biological effects of the immunomodulatory compound

4 July 2017

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2800%2900552-9

Mechanism of action for leflunomide in rheumatoid arthritis

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2800%2900552-9

Leflunomide (HWA 486), a novel immunomodulating compound for the treatment of autoimmune disorders and reactions leading to transplantation rejection

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2800%2900552-9

The adenylate cyclase-cAMP-protein kinase A pathway and regulation of the immune response

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2800%2900552-9

Cyclic AMP is an essential factor in immune responses

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2800%2900552-9

Control of human T-lymphocyte interleukin-2 production by a cAMP-dependent pathway

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2800%2900552-9

Prostaglandin E2 and the increase of intracellular cAMP inhibit the expression of interleukin 2 receptors in human T cells

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2800%2900552-9

Cyclic AMP-mediated alteration of the CD2 activation process in human T lymphocytes. Preferential inhibition of the phosphoinositide cycle-related transduction pathway

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2800%2900552-9

Cyclic AMP counteracts mitogen-induced inositol phosphate generation and increases in intracellular Ca2+ concentrations in human lymphocytes

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2800%2900552-9

Potential use of an antagonist of cAMP-dependent protein kinase to block inhibition and modulate T-cell receptor-triggered activation of cytotoxic T-lymphocytes

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2800%2900552-9

Augmentation of phorbol ester-induced T cell proliferation by agents which raise intracellular cyclic adenosine monophosphate

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2800%2900552-9

CD2 is involved in regulating cyclic AMP levels in T cells

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2800%2900552-9

CD3-dependent increase in cyclic AMP in human T-cells following stimulation of the CD2 receptor

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2800%2900552-9

Rise and Fall of Cyclic AMP Required for Onset of Lymphocyte DNA Synthesis

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2800%2900552-9

A new view of prostaglandin E regulation of the immune response.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2800%2900552-9

Structural and functional comparison of agents interfering with dihydroorotate, succinate and NADH oxidation of rat liver mitochondria

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2800%2900552-9

The interaction of highly active uncouplers with mitochondria

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2800%2900552-9

Effects of various inhibitors of oxidative phosphorylation on energy metabolism, macromolecular synthesis and cyclic AMP production in isolated rat thymocytes. A regulating role for the cellular energy state in macromolecular synthesis and cyclic AM

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2800%2900552-9

Synthesis and biological activity of a series of diaryl-substituted alpha-cyano-beta-hydroxypropenamides, a new class of anthelmintic agents

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2800%2900552-9

Glucose decreases respiratory control ratio in EL-4 tumor cells

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2800%2900552-9

Evaluation of human blood lymphocytes as a model to study the effects of drugs on human mitochondria. Effects of low concentrations of amiodarone on fatty acid oxidation, ATP levels and cell survival

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2800%2900552-9

Purification of human dihydro-orotate dehydrogenase and its inhibition by A77 1726, the active metabolite of leflunomide

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2800%2900552-9

Leflunomide interferes with pyrimidine nucleotide biosynthesis

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2800%2900552-9

Inhibition of dihydroorotate dehydrogenase by the immunosuppressive agent leflunomide

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2800%2900552-9

Blood distribution and single-dose pharmacokinetics of leflunomide

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2800%2900552-9

Inhibition of the epidermal growth factor receptor tyrosine kinase activity by leflunomide

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2800%2900552-9

Inhibition of Protein Tyrosine Phosphorylation in T Cells by a Novel Immunosuppressive Agent, Leflunomide

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2800%2900552-9

10.1016/S0006-2952(00)00552-9

7 January 2021

Identifiers

DOI

1 reference

4 July 2017

1 reference