(Q31864279)

English

Site-directed mutagenesis of K396R of the 65 kDa glutamic acid decarboxylase active site obliterates enzyme activity but not antibody binding.

scientific article

In more languages

Statements

scholarly article

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11163769%20AND%20SRC:MED&resulttype=core&format=json

3 November 2019

Site-directed mutagenesis of K396R of the 65 kDa glutamic acid decarboxylase active site obliterates enzyme activity but not antibody binding (English)

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11163769%20AND%20SRC:MED&resulttype=core&format=json

3 November 2019

0 references

1 reference

based on heuristic

inferred from title

Christiane S Hampe

1

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11163769%20AND%20SRC:MED&resulttype=core&format=json

3 November 2019

author name string

L P Hammerle

2

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11163769%20AND%20SRC:MED&resulttype=core&format=json

3 November 2019

A Falorni

3

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11163769%20AND%20SRC:MED&resulttype=core&format=json

3 November 2019

J Robertson

4

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11163769%20AND%20SRC:MED&resulttype=core&format=json

3 November 2019

A Lernmark

5

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11163769%20AND%20SRC:MED&resulttype=core&format=json

3 November 2019

language of work or name

0 references

publication date

1 January 2001

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11163769%20AND%20SRC:MED&resulttype=core&format=json

3 November 2019

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11163769%20AND%20SRC:MED&resulttype=core&format=json

3 November 2019

488

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11163769%20AND%20SRC:MED&resulttype=core&format=json

3 November 2019

3

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11163769%20AND%20SRC:MED&resulttype=core&format=json

3 November 2019

185-189

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11163769%20AND%20SRC:MED&resulttype=core&format=json

3 November 2019

Motifs and structural fold of the cofactor binding site of human glutamate decarboxylase

1 reference

https://api.crossref.org/works/10.1016%2FS0014-5793%2800%2902429-7

21 January 2018

Structural characteristics of brain glutamate decarboxylase in relation to its interaction and activation

1 reference

https://api.crossref.org/works/10.1016%2FS0014-5793%2800%2902429-7

21 January 2018

Direct Brønsted analysis of the restoration of activity to a mutant enzyme by exogenous amines

1 reference

https://api.crossref.org/works/10.1016%2FS0014-5793%2800%2902429-7

21 January 2018

Lysine-69 plays a key role in catalysis by ornithine decarboxylase through acceleration of the Schiff base formation, decarboxylation, and product release steps

1 reference

https://api.crossref.org/works/10.1016%2FS0014-5793%2800%2902429-7

21 January 2018

Antibodies to a 64,000 Mr human islet cell antigen precede the clinical onset of insulin-dependent diabetes

1 reference

https://api.crossref.org/works/10.1016%2FS0014-5793%2800%2902429-7

21 January 2018

Glutamate decarboxylase-, insulin-, and islet cell-antibodies and HLA typing to detect diabetes in a general population-based study of Swedish children

1 reference

https://api.crossref.org/works/10.1016%2FS0014-5793%2800%2902429-7

21 January 2018

Immune response to glutamic acid decarboxylase correlates with insulitis in non-obese diabetic mice.

1 reference

https://api.crossref.org/works/10.1016%2FS0014-5793%2800%2902429-7

21 January 2018

Spontaneous loss of T-cell tolerance to glutamic acid decarboxylase in murine insulin-dependent diabetes

1 reference

https://api.crossref.org/works/10.1016%2FS0014-5793%2800%2902429-7

21 January 2018

Baculovirus-mediated expression of human 65 kDa and 67 kDa glutamic acid decarboxylases in SF9 insect cells and their relevance in diagnosis of insulin-dependent diabetes mellitus

1 reference

https://api.crossref.org/works/10.1016%2FS0014-5793%2800%2902429-7

21 January 2018

Brain glutamate decarboxylase cloned in lambda gt-11: fusion protein produces gamma-aminobutyric acid

1 reference

https://api.crossref.org/works/10.1016%2FS0014-5793%2800%2902429-7

21 January 2018

Two human glutamate decarboxylases, 65-kDa GAD and 67-kDa GAD, are each encoded by a single gene

1 reference

https://api.crossref.org/works/10.1016%2FS0014-5793%2800%2902429-7

21 January 2018

Non-steady-state kinetics of brain glutamate decarboxylase resulting from interconversion of the apo- and holoenzyme

1 reference

https://api.crossref.org/works/10.1016%2FS0014-5793%2800%2902429-7

21 January 2018

Serum exchange and use of dilutions have improved precision of measurement of islet cell antibodies.

1 reference

https://api.crossref.org/works/10.1016%2FS0014-5793%2800%2902429-7

21 January 2018

GAD autoantibodies in IDDM, stiff-man syndrome, and autoimmune polyendocrine syndrome type I recognize different epitopes

1 reference

https://api.crossref.org/works/10.1016%2FS0014-5793%2800%2902429-7

21 January 2018

Purification and some properties of L-glutamate decarboxylase from human brain

1 reference

https://api.crossref.org/works/10.1016%2FS0014-5793%2800%2902429-7

21 January 2018

Effect of substitution of a lysyl residue that binds pyridoxal phosphate in thermostable D-amino acid aminotransferase by arginine and alanine

1 reference

https://api.crossref.org/works/10.1016%2FS0014-5793%2800%2902429-7

21 January 2018

An anomalous side reaction of the Lys303 mutant aromatic L-amino acid decarboxylase unravels the role of the residue in catalysis

1 reference

https://api.crossref.org/works/10.1016%2FS0014-5793%2800%2902429-7

21 January 2018

64,000 Mr autoantibodies as predictors of insulin-dependent diabetes

1 reference

https://api.crossref.org/works/10.1016%2FS0014-5793%2800%2902429-7

21 January 2018

Antibodies to a Mr-64000 islet cell protein in Swedish children with newly diagnosed Type 1 (insulin-dependent) diabetes

1 reference

https://api.crossref.org/works/10.1016%2FS0014-5793%2800%2902429-7

21 January 2018

Combined use of autoantibodies (IA-2 autoantibody, GAD autoantibody, insulin autoantibody, cytoplasmic islet cell antibodies) in type 1 diabetes: Combinatorial Islet Autoantibody Workshop

1 reference

https://api.crossref.org/works/10.1016%2FS0014-5793%2800%2902429-7

21 January 2018

Control of autoimmune diabetes in NOD mice by GAD expression or suppression in beta cells

1 reference

https://api.crossref.org/works/10.1016%2FS0014-5793%2800%2902429-7

21 January 2018

Administering glutamic acid decarboxylase to NOD mice prevents diabetes

1 reference

https://api.crossref.org/works/10.1016%2FS0014-5793%2800%2902429-7

21 January 2018

Development of the methylotrophic yeast Pichia methanolica for the expression of the 65 kilodalton isoform of human glutamate decarboxylase

1 reference

https://api.crossref.org/works/10.1016%2FS0014-5793%2800%2902429-7

21 January 2018

A novel method for expression and large-scale production of human brain l-glutamate decarboxylase

1 reference

https://api.crossref.org/works/10.1016%2FS0014-5793%2800%2902429-7

21 January 2018

A novel radioligand binding assay to determine diagnostic accuracy of isoform-specific glutamic acid decarboxylase antibodies in childhood IDDM

1 reference

https://api.crossref.org/works/10.1016%2FS0014-5793%2800%2902429-7

21 January 2018

Radioimmunoassays for glutamic acid decarboxylase (GAD65) and GAD65 autoantibodies using 35S or 3H recombinant human ligands

1 reference

https://api.crossref.org/works/10.1016%2FS0014-5793%2800%2902429-7

21 January 2018

High level of concordance between assays for glutamic acid decarboxylase antibodies. The First International Glutamic Acid Decarboxylase Antibody Workshop

1 reference

https://api.crossref.org/works/10.1016%2FS0014-5793%2800%2902429-7

21 January 2018

Radioimmunoassay detects the frequent occurrence of autoantibodies to the Mr 65,000 isoform of glutamic acid decarboxylase in Japanese insulin-dependent diabetes

1 reference

https://api.crossref.org/works/10.1016%2FS0014-5793%2800%2902429-7

21 January 2018

Differential detection of rat islet and brain glutamic acid decarboxylase (GAD) isoforms with sequence-specific peptide antibodies

1 reference

https://api.crossref.org/works/10.1016%2FS0014-5793%2800%2902429-7

21 January 2018

Glutamic acid decarboxylase cDNA: nucleotide sequence encoding an enzymatically active fusion protein

1 reference

https://api.crossref.org/works/10.1016%2FS0014-5793%2800%2902429-7

7 January 2021

Identifiers

10.1016/S0014-5793(00)02429-7

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11163769%20AND%20SRC:MED&resulttype=core&format=json

3 November 2019

release_sxlbfwbx7beqxkqnlzdcljezly

1 reference

https://api.fatcat.wiki/v0/release/sxlbfwbx7beqxkqnlzdcljezly

24 November 2022

based on heuristic

mapped directly with Wikidata item

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11163769%20AND%20SRC:MED&resulttype=core&format=json

3 November 2019

Sitelinks

Wikipedia(0 entries)

Wikibooks(0 entries)

Wikinews(0 entries)

Wikiquote(0 entries)

Wikisource(0 entries)

Wikiversity(0 entries)

Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

Retrieved from "https://www.wikidata.org/w/index.php?title=Q31864279&oldid=1837755292"