(Q32060202)

6 July 2017

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title

Cytopathic hypoxia. Mitochondrial dysfunction as mechanism contributing to organ dysfunction in sepsis (English)

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6 July 2017

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Fink MP

1

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6 July 2017

publication date

1 January 2001

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6 July 2017

published in

Critical Care Clinics

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6 July 2017

volume

17

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6 July 2017

issue

1

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6 July 2017

page(s)

219-237

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Tissue metabolite levels in different types of skeletal muscle during sepsis

6 July 2017

cites work

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7 January 2021

Sequential insult enhances liver macrophage-signaled hepatocyte dysfunction

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7 January 2021

Hepatic Acute Phase Protein Synthesis is Indirectly Regulated by Tumor Necrosis Factor

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7 January 2021

Preliminary studies of energy-rich phosphagens in muscle from severely ill patients

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7 January 2021

Endogenous peroxynitrite mediates mitochondrial dysfunction in rat diaphragm during endotoxemia

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7 January 2021

Skeletal muscle partial pressure of oxygen in patients with sepsis

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7 January 2021

Peripheral oxygen availability within skeletal muscle in sepsis and septic shock: comparison to limited infection and cardiogenic shock

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7 January 2021

Rapid reduction of nitric oxide by mitochondria, and reversible inhibition of mitochondrial respiration by nitric oxide

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7 January 2021

The mitochondrial permeability transition is required for tumor necrosis factor alpha-mediated apoptosis and cytochrome c release

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7 January 2021

Nitric oxide produced by activated astrocytes rapidly and reversibly inhibits cellular respiration

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7 January 2021

Differential inhibitory action of nitric oxide and peroxynitrite on mitochondrial electron transport

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7 January 2021

Recruitment of mitochondrial cyclophilin to the mitochondrial inner membrane under conditions of oxidative stress that enhance the opening of a calcium-sensitive non-specific channel

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7 January 2021

Multiple cytokines are required to induce hepatocyte nitric oxide production and inhibit total protein synthesis

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7 January 2021

Effect of peritonitis on mitochondrial respiration

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7 January 2021

(ADP-ribose)n participates in DNA excision repair

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7 January 2021

Cytopathic hypoxia in sepsis

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7 January 2021

The role of nitric oxide in sepsis and ARDS: synopsis of a roundtable conference held in Brussels on 18-20 March 1995.

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7 January 2021

Mitochondrial death in sepsis: a failed concept

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7 January 2021

Nitric oxide synthase activity in mitochondria

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7 January 2021

Mitochondrial Nitric-oxide Synthase Stimulation Causes CytochromecRelease from Isolated Mitochondria

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7 January 2021

In vivo 31P nuclear magnetic resonance spectroscopy of skeletal muscle energetics in endotoxemic rats: a prospective, randomized study.

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7 January 2021

In vivo effects of lipopolysaccharide on hepatic free-NAD(P)(+)-linked redox states and cytosolic phosphorylation potential in 48-hour-fasted rats.

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7 January 2021

On the Mechanism of Inhibition of CytochromecOxidase by Nitric Oxide

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7 January 2021

Mitochondrial non-specific pores remain closed during cardiac ischaemia, but open upon reperfusion

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7 January 2021

Alterations in renal perfusion and renal energy charge in murine peritonitis

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7 January 2021

Unifying theory of hypoxia tolerance: molecular/metabolic defense and rescue mechanisms for surviving oxygen lack.

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7 January 2021

Reevaluation of the role of cellular hypoxia and bioenergetic failure in sepsis

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7 January 2021

Sepsis does not impair tricarboxylic acid cycle in the heart.

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7 January 2021

Apoptotic cell death in patients with sepsis, shock, and multiple organ dysfunction

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7 January 2021

Oxidative metabolism in rat hepatocytes and mitochondria during sepsis

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7 January 2021

Ileal mucosal oxygen consumption is decreased in endotoxemic rats but is restored toward normal by treatment with aminoguanidine

1 reference

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7 January 2021

Prevention of endotoxin-induced lethality, but not of liver apoptosis in poly(ADP-ribose) polymerase-deficient mice

1 reference

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7 January 2021

Molecular and biochemical features of poly (ADP-ribose) metabolism

1 reference

https://api.crossref.org/works/10.1016%2FS0749-0704%2805%2970161-5

7 January 2021

Effect of injury and sepsis on high-energy phosphates in muscle and red cells

1 reference

https://api.crossref.org/works/10.1016%2FS0749-0704%2805%2970161-5

7 January 2021

Multiple organ dysfunction score: a reliable descriptor of a complex clinical outcome

1 reference

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7 January 2021

Defective oxidative metabolism of rat liver mitochondria in hemorrhagic and endotoxin shock

1 reference

https://api.crossref.org/works/10.1016%2FS0749-0704%2805%2970161-5

7 January 2021

Glucocorticoid receptor antagonism by mifepristone alters phosphocreatine breakdown during sepsis

1 reference

https://api.crossref.org/works/10.1016%2FS0749-0704%2805%2970161-5

7 January 2021

The Duration of Infection Modifies Mitochondrial Oxidative Capacity in Rat Skeletal Muscle

1 reference

https://api.crossref.org/works/10.1016%2FS0749-0704%2805%2970161-5

7 January 2021

Contribution of the mitochondrial permeability transition to lethal injury after exposure of hepatocytes to t-butylhydroperoxide

1 reference

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7 January 2021

Role of glutathione and nitric oxide in the energy metabolism of rat liver mitochondria

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7 January 2021

Resistance to endotoxic shock as a consequence of defective NF-kappaB activation in poly (ADP-ribose) polymerase-1 deficient mice

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7 January 2021

In vivo [31P]NMR assessment of early hepatocellular dysfunction during endotoxemia

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7 January 2021

Hypoxia downregulates expression and activity of epithelial sodium channels in rat alveolar epithelial cells

1 reference

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7 January 2021

Nitric oxide inhibits electron transfer and increases superoxide radical production in rat heart mitochondria and submitochondrial particles

1 reference

https://api.crossref.org/works/10.1016%2FS0749-0704%2805%2970161-5

7 January 2021

Inhibition of mitochondrial electron transport by peroxynitrite

1 reference

https://api.crossref.org/works/10.1016%2FS0749-0704%2805%2970161-5

7 January 2021

The effect of hypodynamic endotoxin shock on myocardial high energy phosphates in the rat.

1 reference

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7 January 2021

The uncoupling protein homologues: UCP1, UCP2, UCP3, StUCP and AtUCP

1 reference

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7 January 2021

Oxygen tension in the bladder epithelium rises in both high and low cardiac output endotoxemic sepsis

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7 January 2021

Dual function for poly(ADP-ribose) synthesis in response to DNA strand breakage

1 reference

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7 January 2021

Involvement of PARP and poly(ADP-ribosyl)ation in the early stages of apoptosis and DNA replication

1 reference

https://api.crossref.org/works/10.1016%2FS0749-0704%2805%2970161-5

7 January 2021

Concurrent quantification of tissue metabolism and blood flow via 2H/31P NMR in vivo. III. Alterations of muscle blood flow and metabolism during sepsis

1 reference

https://api.crossref.org/works/10.1016%2FS0749-0704%2805%2970161-5

7 January 2021

Effect of exogenous and endogenous nitric oxide on mitochondrial respiration of rat hepatocytes

1 reference

https://api.crossref.org/works/10.1016%2FS0749-0704%2805%2970161-5

7 January 2021

Mitochondrial proton leak and the uncoupling proteins

1 reference

https://api.crossref.org/works/10.1016%2FS0749-0704%2805%2970161-5

7 January 2021

Role of poly-ADP ribosyltransferase activation in the vascular contractile and energetic failure elicited by exogenous and endogenous nitric oxide and peroxynitrite

1 reference

https://api.crossref.org/works/10.1016%2FS0749-0704%2805%2970161-5

7 January 2021

Poly (ADP-ribose) synthetase activation mediates pulmonary microvascular and intestinal mucosal dysfunction in endotoxin shock.

1 reference

https://api.crossref.org/works/10.1016%2FS0749-0704%2805%2970161-5

7 January 2021

Endothelial dysfunction in a rat model of endotoxic shock. Importance of the activation of poly (ADP-ribose) synthetase by peroxynitrite

1 reference

https://api.crossref.org/works/10.1016%2FS0749-0704%2805%2970161-5

7 January 2021

Oxygen-dependent regulation of mitochondrial energy metabolism by nitric oxide

1 reference

https://api.crossref.org/works/10.1016%2FS0749-0704%2805%2970161-5

7 January 2021

Alterations of mitochondrial metabolism and protein concentrations in subacute septicemia

1 reference

https://api.crossref.org/works/10.1016%2FS0749-0704%2805%2970161-5

7 January 2021

Inhibition of cytochrome c oxidase in turnover by nitric oxide: mechanism and implications for control of respiration

1 reference

https://api.crossref.org/works/10.1016%2FS0749-0704%2805%2970161-5

7 January 2021

Muscle adenosine 5′-triphosphate and creatine phosphate concentrations in relation to nutritional status and sepsis in man

1 reference

https://api.crossref.org/works/10.1016%2FS0749-0704%2805%2970161-5

7 January 2021

Acidic conditions ameliorate both adenosine triphosphate depletion and the development of hyperpermeability in cultured Caco-2BBe enterocytic monolayers subjected to metabolic inhibition

1 reference

https://api.crossref.org/works/10.1016%2FS0749-0704%2805%2970161-5

7 January 2021

Inhibition of inducible nitric oxide synthase ameliorates endotoxin-induced gut mucosal barrier dysfunction in rats

1 reference

https://api.crossref.org/works/10.1016%2FS0749-0704%2805%2970161-5

7 January 2021

Gut and muscle tissue PO2 in endotoxemic dogs during shock and resuscitation.

1 reference

https://api.crossref.org/works/10.1016%2FS0749-0704%2805%2970161-5

7 January 2021

Endotoxemia causes ileal mucosal acidosis in the absence of mucosal hypoxia in a normodynamic porcine model of septic shock

1 reference

https://api.crossref.org/works/10.1016%2FS0749-0704%2805%2970161-5

7 January 2021

Sepsis alters pyruvate dehydrogenase kinase activity in skeletal muscle

1 reference

https://api.crossref.org/works/10.1016%2FS0749-0704%2805%2970161-5

7 January 2021

The potential role of peroxynitrite in the vascular contractile and cellular energetic failure in endotoxic shock

1 reference

https://api.crossref.org/works/10.1016%2FS0749-0704%2805%2970161-5

7 January 2021

Protective effects of nicotinamide against nitric oxide-mediated delayed vascular failure in endotoxic shock: potential involvement of polyADP ribosyl synthetase

1 reference

https://api.crossref.org/works/10.1016%2FS0749-0704%2805%2970161-5

7 January 2021

10.1016/S0749-0704(05)70161-5

Identifiers

DOI

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6 July 2017

1 reference