Wikidata

(Q3235015)

English

RAD51 recombinase

mammalian protein found in Homo sapiens

  • RecA-like protein
  • DNA repair protein RAD51 homolog 1
  • BRCA1/BRCA2-containing complex, subunit 5
  • RecA, E. coli, homolog of
  • RAD51 homolog A
  • RAD51
  • recombination protein A
In more languages

Statements

molecular function
protein binding
determination method
IPI
56 references
retrieved
8 April 2019
stated in
Regulation of Rad51 function by c-Abl in response to DNA damage
GOA
curator
UniProt
UniProt protein ID
Q06609
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q06609
determination method
IPI
retrieved
8 April 2019
stated in
RAD51AP2, a novel vertebrate- and meiotic-specific protein, shares a conserved RAD51-interacting C-terminal domain with RAD51AP1/PIR51.
GOA
curator
UniProt
UniProt protein ID
Q06609
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q06609
determination method
IPI
retrieved
8 April 2019
stated in
A novel nucleic acid-binding protein that interacts with human rad51 recombinase
GOA
curator
UniProt
UniProt protein ID
Q06609
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q06609
determination method
IPI
retrieved
8 April 2019
stated in
Homologous-recombination-deficient tumours are dependent on Polθ-mediated repair
GOA
curator
UniProt
UniProt protein ID
Q06609
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q06609
determination method
IPI
retrieved
8 April 2019
stated in
Enhancement of RAD51 recombinase activity by the tumor suppressor PALB2.
GOA
curator
UniProt
UniProt protein ID
Q06609
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q06609
determination method
IPI
retrieved
8 April 2019
stated in
The XPB and XPD DNA helicases are components of the p53-mediated apoptosis pathway
GOA
curator
UniProt
UniProt protein ID
Q06609
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q06609
determination method
IPI
retrieved
8 April 2019
stated in
Inhibition of homologous recombination by the PCNA-interacting protein PARI
GOA
curator
UniProt
UniProt protein ID
Q06609
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q06609
determination method
IPI
retrieved
8 April 2019
stated in
Highlight: BRCA1 and BRCA2 proteins in breast cancer
GOA
curator
UniProt
UniProt protein ID
Q06609
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q06609
determination method
IPI
retrieved
8 April 2019
stated in
Scaffolding protein SPIDR/KIAA0146 connects the Bloom syndrome helicase with homologous recombination repair
GOA
curator
UniProt
UniProt protein ID
Q06609
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q06609
determination method
IPI
retrieved
8 April 2019
stated in
A PP4 phosphatase complex dephosphorylates RPA2 to facilitate DNA repair via homologous recombination
GOA
curator
UniProt
UniProt protein ID
Q06609
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q06609
determination method
IPI
retrieved
8 April 2019
stated in
Single-molecule sorting reveals how ubiquitylation affects substrate recognition and activities of FBH1 helicase
GOA
curator
UniProt
UniProt protein ID
Q06609
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q06609
determination method
IPI
retrieved
8 April 2019
stated in
Regulation and localization of the Bloom syndrome protein in response to DNA damage
GOA
curator
UniProt
UniProt protein ID
Q06609
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q06609
determination method
IPI
retrieved
8 April 2019
stated in
The role of the human SWI5-MEI5 complex in homologous recombination repair
GOA
curator
UniProt
UniProt protein ID
Q06609
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q06609
determination method
IPI
retrieved
8 April 2019
stated in
Purified human BRCA2 stimulates RAD51-mediated recombination
GOA
curator
UniProt
UniProt protein ID
Q06609
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q06609
determination method
IPI
retrieved
8 April 2019
stated in
The cell-cycle checkpoint kinase Chk1 is required for mammalian homologous recombination repair
GOA
curator
UniProt
UniProt protein ID
Q06609
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q06609
determination method
IPI
retrieved
8 April 2019
stated in
Insights into DNA recombination from the structure of a RAD51-BRCA2 complex
GOA
curator
UniProt
UniProt protein ID
Q06609
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q06609
determination method
IPI
retrieved
8 April 2019
stated in
XPA versus ERCC1 as chemosensitising agents to cisplatin and mitomycin C in prostate cancer cells: role of ERCC1 in homologous recombination repair
GOA
curator
UniProt
UniProt protein ID
Q06609
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q06609
determination method
IPI
retrieved
8 April 2019
stated in
FBH1 influences DNA replication fork stability and homologous recombination through ubiquitylation of RAD51
GOA
curator
UniProt
UniProt protein ID
Q06609
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q06609
determination method
IPI
retrieved
8 April 2019
stated in
FIGNL1-containing protein complex is required for efficient homologous recombination repair
GOA
curator
UniProt
UniProt protein ID
Q06609
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q06609
determination method
IPI
retrieved
8 April 2019
stated in
RPA-Mediated Recruitment of the E3 Ligase RFWD3 Is Vital for Interstrand Crosslink Repair and Human Health
GOA
curator
UniProt
UniProt protein ID
Q06609
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q06609
determination method
IPI
retrieved
8 April 2019
stated in
FBH1 helicase disrupts RAD51 filaments in vitro and modulates homologous recombination in mammalian cells
GOA
curator
UniProt
UniProt protein ID
Q06609
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q06609
determination method
IPI
retrieved
8 April 2019
stated in
NUCKS1 is a novel RAD51AP1 paralog important for homologous recombination and genome stability
GOA
curator
Parkinsons Disease Gene Ontology Initiative
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q06609
determination method
IPI
retrieved
8 April 2019
stated in
A novel nucleic acid-binding protein that interacts with human rad51 recombinase
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q06609
determination method
IPI
retrieved
8 April 2019
stated in
Breast cancer-associated missense mutants of the PALB2 WD40 domain, which directly binds RAD51C, RAD51 and BRCA2, disrupt DNA repair
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q06609
determination method
IPI
retrieved
8 April 2019
stated in
CDK-dependent phosphorylation of BRCA2 as a regulatory mechanism for recombinational repair
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q06609
determination method
IPI
retrieved
8 April 2019
stated in
WRN interacts physically and functionally with the recombination mediator protein RAD52
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q06609
determination method
IPI
retrieved
8 April 2019
stated in
Homologous-recombination-deficient tumours are dependent on Polθ-mediated repair
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q06609
determination method
IPI
retrieved
8 April 2019
stated in
Enhancement of RAD51 recombinase activity by the tumor suppressor PALB2.
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q06609
determination method
IPI
retrieved
8 April 2019
stated in
Molecular basis for enhancement of the meiotic DMC1 recombinase by RAD51 associated protein 1 (RAD51AP1)
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q06609
determination method
IPI
retrieved
8 April 2019
stated in
Interactions between human BRCA2 protein and the meiosis-specific recombinase DMC1
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q06609
determination method
IPI
retrieved
8 April 2019
stated in
Resistance to therapy caused by intragenic deletion in BRCA2
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q06609
determination method
IPI
retrieved
8 April 2019
stated in
Interaction of p53 with the human Rad51 protein
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q06609
determination method
IPI
retrieved
8 April 2019
stated in
Synaptonemal complex protein SYCP3 impairs mitotic recombination by interfering with BRCA2
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q06609
determination method
IPI
retrieved
8 April 2019
stated in
Interplay between human DNA repair proteins at a unique double-strand break in vivo
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q06609
determination method
IPI
retrieved
8 April 2019
stated in
Human BRCA2 protein promotes RAD51 filament formation on RPA-covered single-stranded DNA.
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q06609
determination method
IPI
retrieved
8 April 2019
stated in
XRCC2 and XRCC3, new human Rad51-family members, promote chromosome stability and protect against DNA cross-links and other damages
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q06609
determination method
IPI
retrieved
8 April 2019
stated in
Compromised BRCA1-PALB2 interaction is associated with breast cancer risk.
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q06609
determination method
IPI
retrieved
8 April 2019
stated in
RAD51-associated protein 1 (RAD51AP1) interacts with the meiotic recombinase DMC1 through a conserved motif
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q06609
determination method
IPI
retrieved
8 April 2019
stated in
ChAM, a novel motif that mediates PALB2 intrinsic chromatin binding and facilitates DNA repair
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q06609
determination method
IPI
retrieved
8 April 2019
stated in
The BRC repeats of human BRCA2 differentially regulate RAD51 binding on single- versus double-stranded DNA to stimulate strand exchange
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q06609
determination method
IPI
retrieved
8 April 2019
stated in
hSWS1·SWSAP1 is an evolutionarily conserved complex required for efficient homologous recombination repair
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q06609
determination method
IPI
retrieved
8 April 2019
stated in
Valine 1532 of human BRC repeat 4 plays an important role in the interaction between BRCA2 and RAD51
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q06609
determination method
IPI
retrieved
8 April 2019
stated in
A mitotic function for the high-mobility group protein HMG20b regulated by its interaction with the BRC repeats of the BRCA2 tumor suppressor
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q06609
determination method
IPI
retrieved
8 April 2019
stated in
Purified human BRCA2 stimulates RAD51-mediated recombination
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q06609
determination method
IPI
retrieved
8 April 2019
stated in
The cell-cycle checkpoint kinase Chk1 is required for mammalian homologous recombination repair
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q06609
determination method
IPI
retrieved
8 April 2019
stated in
The BRC repeats in BRCA2 are critical for RAD51 binding and resistance to methyl methanesulfonate treatment
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q06609
determination method
IPI
retrieved
8 April 2019
stated in
APRIN is a cell cycle specific BRCA2-interacting protein required for genome integrity and a predictor of outcome after chemotherapy in breast cancer
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q06609
determination method
IPI
retrieved
8 April 2019
stated in
Systematic identification of molecular links between core and candidate genes in breast cancer
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q06609
determination method
IPI
retrieved
8 April 2019
stated in
Expression of BRC repeats in breast cancer cells disrupts the BRCA2-Rad51 complex and leads to radiation hypersensitivity and loss of G(2)/M checkpoint control
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q06609
determination method
IPI
retrieved
8 April 2019
stated in
Insights into DNA recombination from the structure of a RAD51-BRCA2 complex
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q06609
determination method
IPI
retrieved
8 April 2019
stated in
MDC1 interacts with Rad51 and facilitates homologous recombination
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q06609
determination method
IPI
retrieved
8 April 2019
stated in
Structure and mechanism of action of the BRCA2 breast cancer tumor suppressor
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q06609
determination method
IPI
retrieved
8 April 2019
stated in
Streamline proteomic approach for characterizing protein-protein interaction network in a RAD52 protein complex
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q06609
determination method
IPI
retrieved
8 April 2019
stated in
The BRC repeats of BRCA2 modulate the DNA-binding selectivity of RAD51
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q06609
determination method
IPI
retrieved
8 April 2019
stated in
Involvement of Rad51C in two distinct protein complexes of Rad51 paralogs in human cells
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q06609
determination method
IPI
retrieved
8 April 2019
stated in
Nucleostemin prevents telomere damage by promoting PML-IV recruitment to SUMOylated TRF1
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q06609
determination method
IPI
identical protein binding
determination method
IPI
7 references
retrieved
8 April 2019
stated in
A novel nucleic acid-binding protein that interacts with human rad51 recombinase
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q06609
determination method
IPI
retrieved
8 April 2019
stated in
Isolation and characterization of RAD51C, a new human member of the RAD51 family of related genes
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q06609
determination method
IPI
retrieved
8 April 2019
stated in
Insights into DNA recombination from the structure of a RAD51-BRCA2 complex
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q06609
determination method
IPI
retrieved
8 April 2019
stated in
Structural transitions within human Rad51 nucleoprotein filaments.
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q06609
determination method
IPI
retrieved
8 April 2019
stated in
XRCC2 and XRCC3, new human Rad51-family members, promote chromosome stability and protect against DNA cross-links and other damages
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q06609
determination method
IPI
retrieved
8 April 2019
stated in
Structure and mechanism of action of the BRCA2 breast cancer tumor suppressor
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q06609
determination method
IPI
retrieved
8 April 2019
stated in
The BRC repeats of human BRCA2 differentially regulate RAD51 binding on single- versus double-stranded DNA to stimulate strand exchange
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q06609
determination method
IPI
cell component
nucleus
determination method
IDA
ISS
IEA
8 references
retrieved
8 April 2019
stated in
GOA
curator
UniProt
UniProt protein ID
Q06609
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q06609
determination method
ISS
retrieved
8 April 2019
stated in
GOA
curator
UniProt
UniProt protein ID
Q06609
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q06609
determination method
IEA
retrieved
8 April 2019
stated in
A novel Fanconi anaemia subtype associated with a dominant-negative mutation in RAD51
GOA
curator
UniProt
UniProt protein ID
Q06609
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q06609
determination method
IDA
retrieved
8 April 2019
stated in
Insights into DNA recombination from the structure of a RAD51-BRCA2 complex
GOA
curator
UniProt
UniProt protein ID
Q06609
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q06609
determination method
IDA
retrieved
8 April 2019
stated in
Identification of a novel human Rad51 variant that promotes DNA strand exchange
GOA
curator
UniProt
UniProt protein ID
Q06609
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q06609
determination method
IDA
retrieved
8 April 2019
stated in
FBH1 influences DNA replication fork stability and homologous recombination through ubiquitylation of RAD51
GOA
curator
UniProt
UniProt protein ID
Q06609
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q06609
determination method
IDA
retrieved
8 April 2019
stated in
Cellular localization of human Rad51C and regulation of ubiquitin-mediated proteolysis of Rad51
GOA
curator
UniProt
UniProt protein ID
Q06609
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q06609
determination method
IDA
retrieved
8 April 2019
stated in
NUCKS1 is a novel RAD51AP1 paralog important for homologous recombination and genome stability
GOA
curator
Parkinsons Disease Gene Ontology Initiative
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q06609
determination method
IDA
biological process
double-strand break repair via homologous recombination
determination method
IDA
TAS
IMP
IEA
6 references
retrieved
8 April 2019
stated in
Complex formation by the human Rad51B and Rad51C DNA repair proteins and their activities in vitro
GOA
curator
UniProt
UniProt protein ID
Q06609
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q06609
determination method
TAS
retrieved
8 April 2019
stated in
A novel Fanconi anaemia subtype associated with a dominant-negative mutation in RAD51
GOA
curator
UniProt
UniProt protein ID
Q06609
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q06609
determination method
IMP
retrieved
8 April 2019
stated in
Scaffolding protein SPIDR/KIAA0146 connects the Bloom syndrome helicase with homologous recombination repair
GOA
curator
UniProt
UniProt protein ID
Q06609
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q06609
determination method
IMP
retrieved
8 April 2019
stated in
RAD51 mutants cause replication defects and chromosomal instability
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q06609
determination method
IMP
retrieved
8 April 2019
stated in
GOA
curator
InterPro
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q06609
determination method
IEA
retrieved
8 April 2019
stated in
Differential contributions of mammalian Rad54 paralogs to recombination, DNA damage repair, and meiosis
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q06609
determination method
IDA
Gene Atlas image
PBB GE RAD51 205024 s at fs.png
732 × 530; 11 KB
0 references

Identifiers

 
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                  Retrieved from "https://www.wikidata.org/w/index.php?title=Q3235015&oldid=2064605608"