(Q33152183)

22 July 2017

1 reference

title

Inherited and acquired vulnerability to ventricular arrhythmias: cardiac Na+ and K+ channels (English)

1 reference

22 July 2017

0 references

Colleen E Clancy

1

1 reference

PubMed ID

15618477

22 July 2017

Robert S Kass

series ordinal

2

1 reference

22 July 2017

1 January 2005

1 reference

22 July 2017

Physiological Reviews

1 reference

22 July 2017

85

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22 July 2017

33-47

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22 July 2017

1

1 reference

Disease-associated mutations in KCNE potassium channel subunits (MiRPs) reveal promiscuous disruption of multiple currents and conservation of mechanism

22 July 2017

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00005.2004

MiRP1 forms IKr potassium channels with HERG and is associated with cardiac arrhythmia

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00005.2004

Stilbenes and fenamates rescue the loss of I(KS) channel function induced by an LQT5 mutation and other IsK mutants

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00005.2004

Novel arrhythmogenic mechanism revealed by a long-QT syndrome mutation in the cardiac Na(+) channel.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00005.2004

Molecular pharmacology of the sodium channel mutation D1790G linked to the long-QT syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00005.2004

Unique topographical distribution of M cells underlies reentrant mechanism of torsade de pointes in the long-QT syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00005.2004

Novel LQT-3 mutation affects Na+ channel activity through interactions between alpha- and beta1-subunits

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00005.2004

K(V)LQT1 and lsK (minK) proteins associate to form the I(Ks) cardiac potassium current

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00005.2004

Molecular mechanism for an inherited cardiac arrhythmia

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00005.2004

Mechanisms of I(Ks) suppression in LQT1 mutants.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00005.2004

Cellular dysfunction of LQT5-minK mutants: abnormalities of IKs, IKr and trafficking in long QT syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00005.2004

Right bundle-branch block and ST-segment elevation in leads V1 through V3: a marker for sudden death in patients without demonstrable structural heart disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00005.2004

Sodium channel blockers identify risk for sudden death in patients with ST-segment elevation and right bundle branch block but structurally normal hearts

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00005.2004

The role of the IsK protein in the specific pharmacological properties of the IKs channel complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00005.2004

Inhibition of IKs in guinea pig cardiac myocytes and guinea pig IsK channels by the chromanol 293B.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00005.2004

Crystal structure and functional analysis of the HERG potassium channel N terminus: a eukaryotic PAS domain

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00005.2004

New approaches to antiarrhythmic therapy, Part I: emerging therapeutic applications of the cell biology of cardiac arrhythmias

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00005.2004

Genetic basis and molecular mechanism for idiopathic ventricular fibrillation

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00005.2004

Homozygous deletion in KVLQT1 associated with Jervell and Lange-Nielsen syndrome.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00005.2004

Properties of KvLQT1 K+ channel mutations in Romano-Ward and Jervell and Lange-Nielsen inherited cardiac arrhythmias

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00005.2004

K+ channel structure-activity relationships and mechanisms of drug-induced QT prolongation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00005.2004

Na(+) channel mutation that causes both Brugada and long-QT syndrome phenotypes: a simulation study of mechanism

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00005.2004

Non-equilibrium gating in cardiac Na+ channels: an original mechanism of arrhythmia

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00005.2004

The Structure of the Potassium Channel: Molecular Basis of K+ Conduction and Selectivity

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00005.2004

Ionic mechanisms responsible for the electrocardiographic phenotype of the Brugada syndrome are temperature dependent

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00005.2004

Action potential and contractility changes in [Na(+)](i) overloaded cardiac myocytes: a simulation study

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00005.2004

Molecular determinants of dofetilide block of HERG K+ channels.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00005.2004

Long QT syndrome-associated mutations in the S4-S5 linker of KvLQT1 potassium channels modify gating and interaction with minK subunits.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00005.2004

Ionic current basis of electrocardiographic waveforms: a model study

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00005.2004

Resurgence of sodium channel research

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00005.2004

Long QT syndrome, Brugada syndrome, and conduction system disease are linked to a single sodium channel mutation

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00005.2004

Block of wild-type and inactivation-deficient cardiac sodium channels IFM/QQQ stably expressed in mammalian cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00005.2004

A novel LQT3 mutation implicates the human cardiac sodium channel domain IVS6 in inactivation kinetics

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00005.2004

Slow delayed rectifier current and repolarization in canine cardiac Purkinje cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00005.2004

Local anesthetics: hydrophilic and hydrophobic pathways for the drug-receptor reaction

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00005.2004

Mechanism of action potential prolongation by RP 58866 and its active enantiomer, terikalant. Block of the rapidly activating delayed rectifier K+ current, IKr.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00005.2004

Potassium channels in the heart Cellular, molecular, and clinical implications

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00005.2004

Regulation of the cardiac repolarizing HERG potassium channel by protein kinase A.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00005.2004

Molecular physiology and pharmacology of HERG. Single-channel currents and block by dofetilide.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00005.2004

Sodium channel inactivation is altered by substitution of voltage sensor positive charges

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00005.2004

Molecular basis of the delayed rectifier current I(ks)in heart

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00005.2004

Requirement of subunit expression for cAMP-mediated regulation of a heart potassium channel

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00005.2004

TEA(+)-sensitive KCNQ1 constructs reveal pore-independent access to KCNE1 in assembled I(Ks) channels

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00005.2004

Novel SCN5A mutation leading either to isolated cardiac conduction defect or Brugada syndrome in a large French family

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00005.2004

Novel gain-of-function mechanism in K(+) channel-related long-QT syndrome: altered gating and selectivity in the HERG1 N629D mutant.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00005.2004

Electrophysiological characterization of an alternatively processed ERG K+ channel in mouse and human hearts

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00005.2004

Ion channels and epilepsy

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00005.2004

Common molecular determinants of flecainide and lidocaine block of heart Na+ channels: evidence from experiments with neutral and quaternary flecainide analogues

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00005.2004

Channel openings are necessary but not sufficient for use-dependent block of cardiac Na(+) channels by flecainide: evidence from the analysis of disease-linked mutations

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00005.2004

Two isoforms of the mouse ether-a-go-go-related gene coassemble to form channels with properties similar to the rapidly activating component of the cardiac delayed rectifier K+ current

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00005.2004

Molecular basis of an inherited epilepsy

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00005.2004

Role of the C-terminal domain in inactivation of brain and cardiac sodium channels

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00005.2004

Requirement of a macromolecular signaling complex for beta adrenergic receptor modulation of the KCNQ1-KCNE1 potassium channel

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00005.2004

A minK-HERG complex regulates the cardiac potassium current I(Kr)

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00005.2004

A structural basis for drug-induced long QT syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00005.2004

Trapping of a methanesulfonanilide by closure of the HERG potassium channel activation gate.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00005.2004

Mutations in a dominant-negative isoform correlate with phenotype in inherited cardiac arrhythmias

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00005.2004

Comparison of clinical and genetic variables of cardiac events associated with loud noise versus swimming among subjects with the long QT syndrome.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00005.2004

Effectiveness and limitations of beta-blocker therapy in congenital long-QT syndrome.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00005.2004

The Na+ channel inactivation gate is a molecular complex: a novel role of the COOH-terminal domain.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00005.2004

A novel mutation in the potassium channel gene KVLQT1 causes the Jervell and Lange-Nielsen cardioauditory syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00005.2004

N-linked glycosylation sites determine HERG channel surface membrane expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00005.2004

ERG proteins and functional cardiac I(Kr) channels in rat, mouse, and human heart.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00005.2004

Expression of distinct ERG proteins in rat, mouse, and human heart. Relation to functional I(Kr) channels.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00005.2004

A novel SCN5A mutation associated with long QT-3: altered inactivation kinetics and channel dysfunction.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00005.2004

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00005.2004

Multiple mechanisms in the long-QT syndrome. Current knowledge, gaps, and future directions. The SADS Foundation Task Force on LQTS.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00005.2004

Inherited long QT syndromes: a paradigm for understanding arrhythmogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00005.2004

Slow conduction in cardiac tissue, I: effects of a reduction of excitability versus a reduction of electrical coupling on microconduction.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00005.2004

Electrophysiology and pharmacology of cardiac arrhythmias. V. Cardiac antiarrhythmic effects of lidocaine

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00005.2004

Electropharmacology of antiarrhythmic drugs

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00005.2004

Molecular determinants of voltage-dependent human ether-a-go-go related gene (HERG) K+ channel block

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00005.2004

Spectrum of HERG K+-channel dysfunction in an inherited cardiac arrhythmia

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00005.2004

Coassembly of K(V)LQT1 and minK (IsK) proteins to form cardiac I(Ks) potassium channel

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00005.2004

A mechanistic link between an inherited and an acquired cardiac arrhythmia: HERG encodes the IKr potassium channel

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00005.2004

Two components of cardiac delayed rectifier K+ current. Differential sensitivity to block by class III antiarrhythmic agents

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00005.2004

Mutations of the S4-S5 linker alter activation properties of HERG potassium channels expressed in Xenopus oocytes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00005.2004

Genotype-phenotype correlation in the long-QT syndrome: gene-specific triggers for life-threatening arrhythmias.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00005.2004

Local anesthetics. Effect of pH on use-dependent block of sodium channels in frog muscle

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00005.2004

Molecular determinants of KCNQ1 channel block by a benzodiazepine

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00005.2004

Pharmacological activation of normal and arrhythmia-associated mutant KCNQ1 potassium channels

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00005.2004

A common polymorphism associated with antibiotic-induced cardiac arrhythmia

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00005.2004

Dominant-negative KvLQT1 mutations underlie the LQT1 form of long QT syndrome.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00005.2004

Conductance and kinetics of delayed rectifier potassium channels in nodal cells of the rabbit heart.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00005.2004

Differential effects of beta-blockade on dispersion of repolarization in the absence and presence of sympathetic stimulation between the LQT1 and LQT2 forms of congenital long QT syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00005.2004

The inward rectification mechanism of the HERG cardiac potassium channel

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00005.2004

Class III antiarrhythmic drugs block HERG, a human cardiac delayed rectifier K+ channel. Open-channel block by methanesulfonanilides

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00005.2004

Spectrum of mutations in long-QT syndrome genes. KVLQT1, HERG, SCN5A, KCNE1, and KCNE2

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00005.2004

Variant of SCN5A sodium channel implicated in risk of cardiac arrhythmia

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00005.2004

Mutations in the hminK gene cause long QT syndrome and suppress IKs function

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00005.2004

Genes and mutations in idiopathic epilepsy

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00005.2004

Accumulation of slowly activating delayed rectifier potassium current (IKs) in canine ventricular myocytes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00005.2004

On the structural basis for size-selective permeation of organic cations through the voltage-gated sodium channel. Effect of alanine mutations at the DEKA locus on selectivity, inhibition by Ca2+ and H+, and molecular sieving

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00005.2004

A sodium-channel mutation causes isolated cardiac conduction disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00005.2004

MinK subdomains that mediate modulation of and association with KvLQT1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00005.2004

Modulation of Cardiac Sodium Channel Gating by Protein Kinase A Can Be Altered by Disease-linked Mutation

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00005.2004

Gating-dependent mechanisms for flecainide action in SCN5A-linked arrhythmia syndromes

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00005.2004

Probing the contribution of IKs to canine ventricular repolarization: key role for beta-adrenergic receptor stimulation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00005.2004

Enhanced Na(+) channel intermediate inactivation in Brugada syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00005.2004

Pharmacological targeting of long QT mutant sodium channels

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00005.2004

Positional cloning of a novel potassium channel gene: KVLQT1 mutations cause cardiac arrhythmias

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00005.2004

A comparison of currents carried by HERG, with and without coexpression of MiRP1, and the native rapid delayed rectifier current. Is MiRP1 the missing link?

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00005.2004

Experimental models of torsades de pointes

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00005.2004

A cluster of hydrophobic amino acid residues required for fast Na(+)-channel inactivation

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00005.2004

Auditory stimuli as a trigger for arrhythmic events differentiate HERG-related (LQTS2) patients from KVLQT1-related patients (LQTS1).

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00005.2004

Pathophysiologic mechanisms of cardiac arrhythmias

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00005.2004

Pathophysiological mechanisms of dominant and recessive KVLQT1 K+ channel mutations found in inherited cardiac arrhythmias.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00005.2004

Molecular architecture of the voltage-dependent Na channel: functional evidence for alpha helices in the pore

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00005.2004

Cellular basis for the normal T wave and the electrocardiographic manifestations of the long-QT syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00005.2004

Cellular basis for the Brugada syndrome and other mechanisms of arrhythmogenesis associated with ST-segment elevation

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00005.2004

Two components of the delayed rectifier K+ current in ventricular myocytes of the guinea pig type. Theoretical formulation and their role in repolarization

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00005.2004

HERG channel dysfunction in human long QT syndrome. Intracellular transport and functional defects

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00005.2004

Linking a genetic defect to its cellular phenotype in a cardiac arrhythmia

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00005.2004

Structural parts involved in activation and inactivation of the sodium channel

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00005.2004

10.1152/PHYSREV.00005.2004

21 January 2018

Identifiers

DOI

1 reference

22 July 2017

1 reference

PubMed ID

15618477