(Q33179776)

English

Partitioning of serpin-proteinase reactions between stable inhibition and substrate cleavage is regulated by the rate of serpin reactive center loop insertion into beta-sheet A.

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scholarly article

1 reference

Europe PubMed Central

23 July 2017

Partitioning of serpin-proteinase reactions between stable inhibition and substrate cleavage is regulated by the rate of serpin reactive center loop insertion into beta-sheet A. (English)

1 reference

Europe PubMed Central

23 July 2017

author name string

Lawrence DA

1

1 reference

Europe PubMed Central

23 July 2017

Olson ST

2

1 reference

Europe PubMed Central

23 July 2017

Muhammad S

3

1 reference

Europe PubMed Central

23 July 2017

Day DE

4

1 reference

Europe PubMed Central

23 July 2017

Kvassman JO

5

1 reference

Europe PubMed Central

23 July 2017

Ginsburg D

6

1 reference

Europe PubMed Central

23 July 2017

Shore JD

7

1 reference

Europe PubMed Central

23 July 2017

language of work or name

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publication date

1 February 2000

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Europe PubMed Central

23 July 2017

Journal of Biological Chemistry

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Europe PubMed Central

23 July 2017

275

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Europe PubMed Central

23 July 2017

8

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Europe PubMed Central

23 July 2017

5839-5844

1 reference

Europe PubMed Central

23 July 2017

Implications of the three-dimensional structure of alpha 1-antitrypsin for structure and function of serpins

1 reference

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21 January 2018

A surprising new protein superfamily containing ovalbumin, antithrombin-III, and alpha 1-proteinase inhibitor

1 reference

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Human alpha 1-proteinase inhibitor. Crystal structure analysis of two crystal modifications, molecular model and preliminary analysis of the implications for function

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Plakalbumin, alpha 1-antitrypsin, antithrombin and the mechanism of inflammatory thrombosis

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Crystal structure of ovalbumin as a model for the reactive centre of serpins

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The intact and cleaved human antithrombin III complex as a model for serpin-proteinase interactions

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Synthesis of pppGpN typs dinucleotide derivatives: the 5′ end sequence of some RNAs

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The active conformation of plasminogen activator inhibitor 1, a target for drugs to control fibrinolysis and cell adhesion

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On the size of the active site in proteases. I. Papain

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Structural basis for serpin inhibitor activity

1 reference

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21 January 2018

Major proteinase movement upon stable serpin-proteinase complex formation

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Implications for function and therapy of a 2.9 A structure of binary-complexed antithrombin

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Interfering with the inhibitory mechanism of serpins: crystal structure of a complex formed between cleaved plasminogen activator inhibitor type 1 and a reactive-centre loop peptide

1 reference

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21 January 2018

Structural transition of alpha 1-antitrypsin by a peptide sequentially similar to beta-strand s4A.

1 reference

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21 January 2018

The acid stabilization of plasminogen activator inhibitor-1 depends on protonation of a single group that affects loop insertion into beta-sheet A.

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21 January 2018

Specific lysine labeling by 18OH- during alkaline cleavage of the alpha-1-antitrypsin-trypsin complex

1 reference

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21 January 2018

The inhibition mechanism of serpins. Evidence that the mobile reactive center loop is cleaved in the native protease-inhibitor complex.

1 reference

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21 January 2018

An ester bond linking a fragment of a serine proteinase to its serpin inhibitor.

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Engineering plasminogen activator inhibitor 1 mutants with increased functional stability.

1 reference

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A fluorescent probe study of plasminogen activator inhibitor-1. Evidence for reactive center loop insertion and its role in the inhibitory mechanism

1 reference

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21 January 2018

Purification of active human plasminogen activator inhibitor 1 from Escherichia coli. Comparison with natural and recombinant forms purified from eucaryotic cells

1 reference

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21 January 2018

Alpha 1-proteinase inhibitor variant T345R. Influence of P14 residue on substrate and inhibitory pathways

1 reference

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21 January 2018

C1 inhibitor hinge region mutations produce dysfunction by different mechanisms

1 reference

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21 January 2018

Role of the catalytic serine in the interactions of serine proteinases with protein inhibitors of the serpin family. Contribution of a covalent interaction to the binding energy of serpin-proteinase complexes.

1 reference

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21 January 2018

The role of conformational change in serpin structure and function

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21 January 2018

Effects of serpin binding on the target proteinase: global stabilization, localized increased structural flexibility, and conserved hydrogen bonding at the active site.

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21 January 2018

Structural basis of latency in plasminogen activator inhibitor-1

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21 January 2018

Importance of the P2 glycine of antithrombin in target proteinase specificity, heparin activation, and the efficiency of proteinase trapping as revealed by a P2 Gly --> Pro mutation.

1 reference

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21 January 2018

Angiotensinogen is related to the antitrypsin-antithrombin-ovalbumin family

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21 January 2018

Properties of thrombin- and elastase-modified human antithrombin III

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21 January 2018

Crystal structure of an uncleaved serpin reveals the conformation of an inhibitory reactive loop

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21 January 2018

Serpin-protease complexes are trapped as stable acyl-enzyme intermediates

1 reference

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21 January 2018

Time-resolved polarized fluorescence spectroscopy studies of plasminogen activator inhibitor type 1: conformational changes of the reactive center upon interactions with target proteases, vitronectin and heparin

1 reference

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21 January 2018

Structural insights into serpin-protease complexes reveal the inhibitory mechanism of serpins

1 reference

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21 January 2018

On the structure of the stable complex between plasmin and α2 -antiplasmin

1 reference

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21 January 2018

Inhibitory mechanism of serpins: loop insertion forces acylation of plasminogen activator by plasminogen activator inhibitor-1

1 reference

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21 January 2018

Distortion of the active site of chymotrypsin complexed with a serpin

1 reference

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21 January 2018

Proteinase specificity and functional diversity in point mutants of plasminogen activator inhibitor 1

1 reference

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21 January 2018

Mechanism of serpin action: evidence that C1 inhibitor functions as a suicide substrate

1 reference

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21 January 2018

Arginine substitutions in the hinge region of antichymotrypsin affect serpin beta-sheet rearrangement

1 reference

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21 January 2018

Conformational changes of the reactive-centre loop and beta-strand 5A accompany temperature-dependent inhibitor-substrate transition of plasminogen-activator inhibitor 1

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21 January 2018

Identifiers

10.1074/JBC.275.8.5839

1 reference

Europe PubMed Central

23 July 2017

1 reference

Europe PubMed Central

23 July 2017

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