(Q33182080)

23 July 2017

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title

Role of formulation vehicles in taxane pharmacology (English)

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23 July 2017

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van Zuylen L

1

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23 July 2017

Verweij J

series ordinal

2

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23 July 2017

Sparreboom A

series ordinal

3

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23 July 2017

publication date

1 May 2001

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Investigational New Drugs

23 July 2017

published in

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23 July 2017

volume

19

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23 July 2017

issue

2

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23 July 2017

page(s)

125-141

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Plasma concentrations of polysorbate 80 measured in patients following administration of docetaxel or etoposide

23 July 2017

cites work

1 reference

12 December 2020

Complement activation by Cremophor EL as a possible contributor to hypersensitivity to paclitaxel: an in vitro study

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12 December 2020

Coadministration of oral cyclosporin A enables oral therapy with paclitaxel

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12 December 2020

Allergic reactions to teniposide in patients with neuroblastoma and lymphoid malignancies.

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12 December 2020

Disposition of [G-(3)H]paclitaxel and cremophor EL in a patient with severely impaired renal function

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12 December 2020

[Study for modifying activity of solvents on antitumor activity of paclitaxel]

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12 December 2020

Cholestatic effects of cyclosporine in the rat

1 reference

12 December 2020

Combined doxorubicin and paclitaxel in advanced breast cancer: Effective and cardiotoxic

1 reference

12 December 2020

Current sample handling methods for measurement of platinum-DNA adducts in leucocytes in man lead to discrepant results in DNA adduct levels and DNA repair

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12 December 2020

Hypersensitivity reactions from taxol

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12 December 2020

Sequence-dependent alteration of doxorubicin pharmacokinetics by paclitaxel in a phase I study of paclitaxel and doxorubicin in patients with metastatic breast cancer

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12 December 2020

European-Canadian randomized trial of paclitaxel in relapsed ovarian cancer: high-dose versus low-dose and long versus short infusion

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12 December 2020

Isolation of mast cells from rabbit lung and liver: comparison of histamine release induced by the hypnotics Althesin and propanidid.

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12 December 2020

Rapid esterase-sensitive breakdown of polysorbate 80 and its impact on the plasma pharmacokinetics of docetaxel and metabolites in mice

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12 December 2020

Antiproliferative effects of paclitaxel (Taxol) on human renal clear cell carcinomas in vitro

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12 December 2020

Emulsifier for intravenous cyclosporin inhibits neurite outgrowth, causes deficits in rapid axonal transport and leads to structural abnormalities in differentiating N1E.115 neuroblastoma

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12 December 2020

Effect of combination of suboptimal concentrations of P-glycoprotein blockers on the proliferation of MDR1 gene expressing cells

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12 December 2020

Inhibition of paclitaxel elimination in the isolated perfused rat liver by Cremophor EL

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12 December 2020

Inhibition of etoposide elimination in the isolated perfused rat liver by Cremophor EL and Tween 80.

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12 December 2020

Prospective assessment of cardiac toxicity during a randomized phase II trial of doxorubicin and paclitaxel in metastatic breast cancer

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12 December 2020

Determination of polysorbates in foods by colorimetry with confirmation by infrared spectrophotometry, thin-layer chromatography, and gas chromatography

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12 December 2020

Reversal of multidrug resistance by surfactants

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12 December 2020

Differential modulation of cisplatin accumulation in leukocytes and tumor cell lines by the paclitaxel vehicle Cremophor EL.

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12 December 2020

The solvents cremophor EL and Tween 80 modulate daunorubicin resistance in the multidrug resistant Ehrlich ascites tumor.

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12 December 2020

Paclitaxel pharmacokinetics and pharmacodynamics

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12 December 2020

Central nervous system toxicity after liver transplantation. The role of cyclosporine and cholesterol

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12 December 2020

Titrimetric determination of Cremophor EL in aqueous solutions and biofluids: part 2: ruggedness of the method with respect to biofluids

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12 December 2020

Linearized colorimetric assay for cremophor EL: application to pharmacokinetics after 1-hour paclitaxel infusions.

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12 December 2020

The distribution of systemically administered [3H]-paclitaxel in rats: a quantitative autoradiographic study

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12 December 2020

Effects of polysorbate 80 on the absorption and distribution of oral methotrexate (MTX) in mice.

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12 December 2020

Sequences of taxol and cisplatin: a phase I and pharmacologic study

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12 December 2020

Clinical pharmacokinetics and pharmacodynamics of paclitaxel: a 3-hour infusion versus a 24-hour infusion.

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12 December 2020

The determination of polysorbate 60 in foods

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12 December 2020

Cremophor reduces paclitaxel penetration into bladder wall during intravesical treatment

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12 December 2020

Influence of polysorbate 80 (Tween 80) and etoposide (VP-16-213) on the pharmacokinetics and urinary excretion of adriamycin and its metabolites in cancer patients

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12 December 2020

Absorption and Excretion of Drugs. XXVII. Effect of Nonionic Surface-Active Agents on Rectal Absorption of Sulfonamides

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12 December 2020

Taxol: a review of its preclinical in vivo antitumor activity

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12 December 2020

Effects of paclitaxel with or without cremophor EL on cellular clonogenic survival and apoptosis

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12 December 2020

Phase I trial of cremophor EL with bolus doxorubicin.

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12 December 2020

The polyoxyethylene castor oil Cremophor EL modifies multidrug resistance

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12 December 2020

Haematopoietic radioprotection by Cremophor EL: a polyethoxylated castor oil.

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12 December 2020

A general model for time-dissociated pharmacokinetic-pharmacodynamic relationship exemplified by paclitaxel myelosuppression

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12 December 2020

Pharmacokinetics of the taxanes

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12 December 2020

Tween 80 increases plasma adriamycin concentrations in mice by an apparent reduction of plasma volume

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12 December 2020

Differential modulation of P-glycoprotein, the multidrug resistance mediator, by Cremophor in normal versus leukemic hematopoietic cells

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12 December 2020

Phase I trial of taxol given as a 24-hour infusion every 21 days: responses observed in metastatic melanoma.

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12 December 2020

Effects of Taxol on blood cells

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12 December 2020

Reversal of the multidrug resistance phenotype with cremophor EL, a common vehicle for water-insoluble vitamins and drugs

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12 December 2020

Taxol: a history of pharmaceutical development and current pharmaceutical concerns

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12 December 2020

Sequence-dependent hematological toxicity associated with the 3-hour paclitaxel/cyclophosphamide doublet

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12 December 2020

Quantitative determination of polysorbate to in non-standard salad dressings

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12 December 2020

ThioTEPA pharmacokinetics during intravesical chemotherapy and the influence of Tween 80

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12 December 2020

Measurement of cremophor EL following taxol: plasma levels sufficient to reverse drug exclusion mediated by the multidrug-resistant phenotype

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12 December 2020

The influence of the cyclosporine vehicle, cremophor EL, on renal microvascular blood flow in the rat

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12 December 2020

Cytotoxic studies of paclitaxel (Taxol) in human tumour cell lines

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12 December 2020

Clinical relevance of P-glycoprotein expression in haematological malignancies

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12 December 2020

A Phase I study of continuous infusion doxorubicin and paclitaxel chemotherapy with granulocyte colony-stimulating factor for relapsed epithelial ovarian cancer

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12 December 2020

Effects of Cremophor EL on distribution of Taxol to serum lipoproteins.

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12 December 2020

Use of the isolated perfused kidney model to assess the acute pharmacologic effects of cyclosporine and its vehicle, cremophor EL

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12 December 2020

Clinical pharmacology of carboplatin administered in combination with paclitaxel

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12 December 2020

Overview of Taxol safety.

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12 December 2020

Analysis of polysorbate and its polyoxyethylated metabolite

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12 December 2020

Comparison of cyclosporin A, verapamil, PSC-833 and cremophor EL as enhancing agents of VP-16 in murine lymphoid leukemias

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12 December 2020

Phase I study of paclitaxel in combination with cyclophosphamide and granulocyte colony-stimulating factor in metastatic breast cancer patients

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12 December 2020

Disposition of Cremophor EL in humans limits the potential for modulation of the multidrug resistance phenotype in vivo

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12 December 2020

Modulation of P-glycoprotein-mediated drug transport by alterations in lipid fluidity of rat liver canalicular membrane vesicles

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12 December 2020

Cremophor EL causes (pseudo-) non-linear pharmacokinetics of paclitaxel in patients

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12 December 2020

Phase I and pharmacologic study of docetaxel and cisplatin in patients with advanced solid tumors

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12 December 2020

Inter-relationships of paclitaxel disposition, infusion duration and cremophor EL kinetics in cancer patients

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12 December 2020

Effect of Tween-80 on cell killing by etoposide in human lung adenocarcinoma cells

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12 December 2020

Pharmacokinetics of paclitaxel and metabolites in a randomized comparative study in platinum-pretreated ovarian cancer patients

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12 December 2020

Contact allergenic activity of Tween 80 before and after air exposure

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12 December 2020

Limited oral bioavailability and active epithelial excretion of paclitaxel (Taxol) caused by P-glycoprotein in the intestine

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12 December 2020

Tissue distribution, metabolism and excretion of paclitaxel in mice

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12 December 2020

Phase I and pharmacologic study of sequences of paclitaxel and cyclophosphamide supported by granulocyte colony-stimulating factor in women with previously treated metastatic breast cancer

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12 December 2020

Nonlinear pharmacokinetics and metabolism of paclitaxel and its pharmacokinetic/pharmacodynamic relationships in humans

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12 December 2020

Role of the carrier solution in cyclosporine pharmacokinetics in the baboon

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12 December 2020

Quantitation of Cremophor EL in human plasma samples using a colorimetric dye-binding microassay

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12 December 2020

Properties of cremophor EL micelles probed by fluorescence

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12 December 2020

Biodistribution and PDT efficacy of a ketochlorin photosensitizer as a function of the delivery vehicle

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12 December 2020

Complement-mediated reactions to diazepam with Cremophor as solvent (Stesolid MR).

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12 December 2020

Cholestasis in the rat by means of intravenous administration of cyclosporine vehicle, Cremophor EL

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12 December 2020

Pharmacokinetic interactions of paclitaxel, docetaxel and their vehicles with doxorubicin

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12 December 2020

The pharmacokinetics of epirubicin and docetaxel in combination in rats

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12 December 2020

Treatment of reticulum cell sarcoma in SJL/J mice with Tween 80.

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12 December 2020

Effect of the paclitaxel vehicle, Cremophor EL, on the pharmacokinetics of doxorubicin and doxorubicinol in mice

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12 December 2020

Pharmacokinetics of paclitaxel and carboplatin in a dose-escalating and dose-sequencing study in patients with non-small-cell lung cancer. The European Cancer Centre

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12 December 2020

Cremophor EL, a widely used parenteral vehicle, is a potent inhibitor of protein kinase C.

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12 December 2020

Determination of polysorbate in ascites fluid from a premature infant

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12 December 2020

Differential activity of Cremophor EL and paclitaxel in patients' tumor cells and human carcinoma cell lines in vitro

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12 December 2020

Doxorubicin/paclitaxel combination chemotherapy for metastatic breast cancer: the Eastern Cooperative Oncology Group experience

1 reference

12 December 2020

Comparative effects of paclitaxel and docetaxel on the metabolism and pharmacokinetics of epirubicin in breast cancer patients

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12 December 2020

Is Cremophor EL, solvent for paclitaxel, cytotoxic?

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12 December 2020

Synergistic reversal of multidrug-resistance phenotype in acute myeloid leukemia cells by cyclosporin A and cremophor EL.

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12 December 2020

Taxoids in combination with anthracyclines and other agents: pharmacokinetic considerations

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12 December 2020

Effects of cyclosporine on the isolated perfused rat kidney

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12 December 2020

Anaphylactoid reactions associated with parenteral cyclosporine use: possible role of Cremophor EL

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12 December 2020

Reversal of multidrug resistance phenotype by surfactants: relationship to membrane lipid fluidity

1 reference

12 December 2020

The influence of Cremophor EL on the cell cycle effects of paclitaxel (Taxol) in human tumor cell lines

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12 December 2020

Paclitaxel (Taxol) and docetaxel (Taxotere): not simply two of a kind

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12 December 2020

Determination of polyoxyethyleneglycerol triricinoleate 35 (Cremophor EL) in plasma by pre-column derivatization and reversed-phase high-performance liquid chromatography

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12 December 2020

Cremophor pharmacokinetics in patients receiving 3-, 6-, and 24-hour infusions of paclitaxel

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12 December 2020

Cremophor EL reversed multidrug resistance in vitro but not in tumor-bearing mouse models

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12 December 2020

Successful parenteral desensitization to paclitaxel

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12 December 2020

Analysis of exposure times and dose escalation of paclitaxel in ovarian cancer cell lines

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12 December 2020

The cytotoxic activity of Taxol in primary cultures of tumour cells from patients is partly mediated by Cremophor EL.

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12 December 2020

Cremophor-EL enhances taxol efficacy in a multi-drug resistant C1300 neuroblastoma cell line.

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12 December 2020

Cremophor EL, solvent for paclitaxel, and toxicity

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12 December 2020

Intermediary metabolism of certain polyoxyethylene derivatives in man. I. Recovery of the polyoxyethylene moiety from urine and faces following ingestion of polyoxyethylene (40) mono-stearate

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12 December 2020

Human pharmacokinetic characterization and in vitro study of the interaction between doxorubicin and paclitaxel in patients with breast cancer

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12 December 2020

Paclitaxel by 3-hour infusion in combination with bolus doxorubicin in women with untreated metastatic breast cancer: high antitumor efficacy and cardiac effects in a dose-finding and sequence-finding study.

1 reference

12 December 2020

Cremophor EL pharmacokinetics in a phase I study of paclitaxel (Taxol) and carboplatin in non-small cell lung cancer patients

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12 December 2020

Study of histamine release induced by acute administration of antitumor agents in dogs

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12 December 2020

Nonlinear pharmacokinetics of paclitaxel in mice results from the pharmaceutical vehicle Cremophor EL

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12 December 2020

Pharmacokinetics of propofol ('Diprivan') as an induction agent.

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12 December 2020

The distribution and elimination of methotrexate in mouse blood and brain after concurrent administration of polysorbate 80.

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12 December 2020

Effect of a detergent on gastrointestinal absorption of a steroid

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12 December 2020

Fractionation of Cremophor EL delineates components responsible for plasma lipoprotein alterations and multidrug resistance reversal

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12 December 2020

Adverse reactions to intravenous anaesthetic induction agents.

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12 December 2020

Cremophor EL-mediated alteration of paclitaxel distribution in human blood: clinical pharmacokinetic implications.

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12 December 2020

Plant antitumor agents. VI. The isolation and structure of taxol, a novel antileukemic and antitumor agent from Taxus brevifolia

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12 December 2020

Histamine release in dogs by Cremophor El® and its derivatives: Oxethylated oleic acid is the most effective constituent

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12 December 2020

Paclitaxel-induced cytotoxicity--the effects of cremophor EL (castor oil) on two human breast cancer cell lines with acquired multidrug resistant phenotype and induced expression of the permeability glycoprotein.

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12 December 2020

Pharmacology and toxicology of Cremophor EL diluent

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12 December 2020

Quantitative determination of polysorbate 20 in nasal pharmaceutical preparations by high-performance liquid chromatography

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12 December 2020

Potentiation of anticancer-drug cytotoxicity by multidrug-resistance chemosensitizers involves alterations in membrane fluidity leading to increased membrane permeability.

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12 December 2020

Indirect-response model for the time course of leukopenia with anticancer drugs.

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12 December 2020

Cremophor and Emulphor induced alterations of serum lipids and lipoprotein electrophoretic patterns of dogs

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12 December 2020

Proliferation, migration and invasion of human glioma cells exposed to paclitaxel (Taxol) in vitro

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12 December 2020

Potential neurotoxicity of the solvent vehicle for cyclosporine

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12 December 2020

Identifiers

DOI

10.1023/A:1010618632738

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Dimensions Publication ID

23 July 2017

1003425850

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