(Q33213315)

24 July 2017

Myocilin mutations causing glaucoma inhibit the intracellular endoproteolytic cleavage of myocilin between amino acids Arg226 and Ile227. (English)

1 reference

24 July 2017

J Daniel Aroca-Aguilar

1

1 reference

24 July 2017

Francisco Sánchez-Sánchez

2

1 reference

24 July 2017

Sikha Ghosh

3

1 reference

24 July 2017

Miguel Coca-Prados

4

1 reference

24 July 2017

Julio Escribano

5

1 reference

24 July 2017

language of work or name

English

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publication date

28 March 2005

1 reference

Journal of Biological Chemistry

24 July 2017

9

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based on heuristic

inferred from page(s)

published in

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24 July 2017

280

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24 July 2017

22

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24 July 2017

21043-21051

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Cellular pharmacology and molecular biology of the trabecular meshwork inducible glucocorticoid response gene product

24 July 2017

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M501340200

Isolation and characterization of cell-specific cDNA clones from a subtractive library of the ocular ciliary body of a single normal human donor: transcription and synthesis of plasma proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M501340200

Cloning and characterization of subtracted cDNAs from a human ciliary body library encoding TIGR, a protein involved in juvenile open angle glaucoma with homology to myosin and olfactomedin.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M501340200

A novel myosin-like protein (myocilin) expressed in the connecting cilium of the photoreceptor: molecular cloning, tissue expression, and chromosomal mapping

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M501340200

Differential gene expression in the human ciliary epithelium

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M501340200

Expression and characterization of the olfactomedin domain of human myocilin

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M501340200

Recent advances in molecular genetics of glaucomas

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M501340200

Recurrent mutations in a single exon encoding the evolutionarily conserved olfactomedin-homology domain of TIGR in familial open-angle glaucoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M501340200

Altered secretion of a TIGR/MYOC mutant lacking the olfactomedin domain

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M501340200

Non-secretion of mutant proteins of the glaucoma gene myocilin in cultured trabecular meshwork cells and in aqueous humor

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M501340200

Gene structure and properties of TIGR, an olfactomedin-related glycoprotein cloned from glucocorticoid-induced trabecular meshwork cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M501340200

A cellular assay distinguishes normal and mutant TIGR/myocilin protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M501340200

Reversal of mutant myocilin non-secretion and cell killing: implications for glaucoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M501340200

Homozygotes carrying an autosomal dominant TIGR mutation do not manifest glaucoma.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M501340200

Targeted Disruption of the Myocilin Gene (Myoc) Suggests that Human Glaucoma-Causing Mutations Are Gain of Function

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M501340200

Transformation of human ciliary epithelial cells by simian virus 40: induction of cell proliferation and retention of beta 2-adrenergic receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M501340200

Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M501340200

Staining of proteins on gels: comparisons of dyes and procedures.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M501340200

Rapid mass spectrometric identification of proteins from two-dimensional polyacrylamide gels after in gel proteolytic digestion.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M501340200

The Pfam protein families database

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M501340200

ELM server: A new resource for investigating short functional sites in modular eukaryotic proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M501340200

A novel Asp380Ala mutation in the GLC1A/myocilin gene in a family with juvenile onset primary open angle glaucoma.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M501340200

Accumulation of mutant myocilins in ER leads to ER stress and potential cytotoxicity in human trabecular meshwork cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M501340200

Perfusion with the Olfactomedin Domain of Myocilin Does Not Affect Outflow Facility

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M501340200

Novel TIGR/MYOC mutations in families with juvenile onset primary open angle glaucoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M501340200

DomCut: prediction of inter-domain linker regions in amino acid sequences.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M501340200

Proteolytic processing in the secretory pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M501340200

Furin at the cutting edge: from protein traffic to embryogenesis and disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M501340200

Age-dependent prevalence of mutations at the GLC1A locus in primary open-angle glaucoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M501340200

21 January 2018

Identifiers

DOI

10.1074/JBC.M501340200

1 reference

24 July 2017

1 reference