(Q33225886)

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RNAi-based screening of the human kinome identifies Akt-cooperating kinases: a new approach to designing efficacious multitargeted kinase inhibitors.

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8 January 2020

RNAi-based screening of the human kinome identifies Akt-cooperating kinases: a new approach to designing efficacious multitargeted kinase inhibitors (English)

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8 January 2020

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Mark E Schurdak

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8 January 2020

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Morgan-Lappe S

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8 January 2020

Woods KW

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8 January 2020

Li Q

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8 January 2020

Anderson MG

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8 January 2020

Luo Y

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8 January 2020

Giranda VL

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8 January 2020

Fesik SW

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8 January 2020

Leverson JD

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1 March 2006

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8 January 2020

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8 January 2020

25

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8 January 2020

1340-1348

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8 January 2020

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8 January 2020

https://scigraph.springernature.com/pub.10.1038/sj.onc.1209169

0 references

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Oncogenic kinase signalling

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Protein kinases--the major drug targets of the twenty-first century?

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A Bcr/Abl-independent, Lyn-dependent form of imatinib mesylate (STI-571) resistance is associated with altered expression of Bcl-2.

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SRCircumventing imatinib resistance

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BCR-ABL independence and LYN kinase overexpression in chronic myelogenous leukemia cells selected for resistance to STI571.

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Perspectives on the development of a molecularly targeted agent

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Analysis of gene function in somatic mammalian cells using small interfering RNAs

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Identification of a PKB/Akt hydrophobic motif Ser-473 kinase as DNA-dependent protein kinase

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Structure of a human inositol 1,4,5-trisphosphate 3-kinase: substrate binding reveals why it is not a phosphoinositide 3-kinase

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Structure, regulation and function of PKB/AKT--a major therapeutic target

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7 January 2021

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Binding of inositol phosphate to DNA-PK and stimulation of double-strand break repair

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7 January 2021

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Specific interaction of IP6 with human Ku70/80, the DNA-binding subunit of DNA-PK

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7 January 2021

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A library of siRNA duplexes targeting the phosphoinositide 3-kinase pathway: determinants of gene silencing for use in cell-based screens

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Noise amidst the silence: off-target effects of siRNAs?

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Expression profiling reveals off-target gene regulation by RNAi

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Structural insights into the regulation of PDK1 by phosphoinositides and inositol phosphates.

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Cloning and chromosome mapping of the human casein kinase I gamma3 gene (CSNK1G3)

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7 January 2021

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Targeting the PI3K-Akt pathway in human cancer: rationale and promise

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Potent and selective inhibitors of Akt kinases slow the progress of tumors in vivo

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Binding of inositol hexakisphosphate (IP6) to Ku but not to DNA-PKcs

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7 January 2021

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Sensitized RNAi screen of human kinases and phosphatases identifies new regulators of apoptosis and chemoresistance.

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The Akt pathway: molecular targets for anti-cancer drug development

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7 January 2021

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Inositol pentakisphosphate promotes apoptosis through the PI 3-K/Akt pathway

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A multitargeted, metronomic, and maximum-tolerated dose "chemo-switch" regimen is antiangiogenic, producing objective responses and survival benefit in a mouse model of cancer.

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p38 Kinase-dependent MAPKAPK-2 activation functions as 3-phosphoinositide-dependent kinase-2 for Akt in human neutrophils

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Short interfering RNAs can induce unexpected and divergent changes in the levels of untargeted proteins in mammalian cells

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The phosphatidylinositol 3-Kinase AKT pathway in human cancer

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Survival signalling by Akt and eIF4E in oncogenesis and cancer therapy

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Identifiers

10.1038/SJ.ONC.1209169

1 reference

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8 January 2020

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8 January 2020

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