(Q33282271)

25 July 2017

title

A unified synthetic approach to polyketides having both skeletal and stereochemical diversity (English)

1 reference

25 July 2017

Shiying Shang

1

1 reference

25 July 2017

Hayato Iwadare

2

1 reference

25 July 2017

Daniel E Macks

3

1 reference

25 July 2017

Lisa M Ambrosini

4

1 reference

25 July 2017

Derek S Tan

5

1 reference

25 July 2017

language of work or name

English

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publication date

17 April 2007

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25 July 2017

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25 July 2017

volume

9

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25 July 2017

issue

10

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25 July 2017

page(s)

1895-1898

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Assembly-line enzymology for polyketide and nonribosomal Peptide antibiotics: logic, machinery, and mechanisms.

25 July 2017

cites work

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2597797

Short synthesis of skeletally and stereochemically diverse small molecules by coupling petasis condensation reactions to cyclization reactions

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2597797

Diversity-oriented synthesis: exploring the intersections between chemistry and biology

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2597797

Advancing chemistry and biology through diversity-oriented synthesis of natural product-like libraries

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2597797

A planning strategy for diversity-oriented synthesis

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2597797

Generating Diverse Skeletons of Small Molecules Combinatorially

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2597797

High-affinity mu opioid receptor ligands discovered by the screening of an exhaustively stereodiversified library of 1,5-enediols

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2597797

Generation of libraries of pharmacophoric structures with increased complexity and diversity by employing polymorphic scaffolds

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2597797

A combinatorial scaffold approach toward kinase-directed heterocycle libraries

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2597797

Building a small polypropionate library. Synthesis of all possible stereotetrads (building blocks for polyketide synthesis) from furan

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2597797

Antiangiogenic effect of KR31372 in rat sponge implant model

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2597797

High stereochemical diversity and applications for the synthesis of marine natural products: a library of carbohydrate mimics and polyketide segments

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2597797

High-diversity combinatorial libraries

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2597797

Target-oriented and diversity-oriented organic synthesis in drug discovery

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2597797

Synthetic studies on (2R,4'R,8'R)-alpha-tocopherol. Facile syntheses of optically active, saturated, acyclic isoprenoids via stereospecific [3,3]sigmatropic rearrangements

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2597797

Exploring skeletal diversity via ring contraction of glycal-derived scaffolds.

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2597797

Stereocontrolled synthesis of spiroketals via Ti(Oi-Pr)4-mediated kinetic spirocyclization of glycal epoxides with retention of configuration

31 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2597797

Stereocontrolled synthesis of spiroketals via a remarkable methanol-induced kinetic spirocyclization reaction

31 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2597797

Synthetic strategy toward skeletal diversity via solid-supported, otherwise unstable reactive intermediates

31 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2597797

Skeletal diversity via a branched pathway: efficient synthesis of 29 400 discrete, polycyclic compounds and their arraying into stock solutions.

31 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2597797

Molecular modeling of 3-arylisoquinoline antitumor agents active against A-549. A comparative molecular field analysis study

31 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2597797

Pairwise use of complexity-generating reactions in diversity-oriented organic synthesis.

31 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2597797

A Synthesis Strategy Yielding Skeletally Diverse Small Molecules Combinatorially

31 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2597797

Regioselective alkyl and alkynyl substitution reactions of epoxy alcohols by the use of organoaluminum ate complexes: regiochemical reversal of nucleophilic substitution reactions

10 December 2018

1 reference

12 December 2020

Synthesis and enzymic activity of 6-carbethoxy- and 6-ethoxy-3,7-disubstituted pyrazolo[1,5-a]pyrimidines and related derivatives as adenosine cyclic 3',5'-phosphate phosphodiesterase inhibitors

1 reference

12 December 2020

Diversity-oriented synthesis of polyketide natural products via iterative chemo- and stereoselective functionalization of polyenoates: development of a unified approach for the C(1-19) segments of lituarines A-C

1 reference

12 December 2020

Methods for drug discovery: development of potent, selective, orally effective cholecystokinin antagonists

1 reference

12 December 2020

A Combinatorial Approach to Polyketide-Type Libraries by Iterative Asymmetric Aldol Reactions Performed on Solid Support We thank the European Commission (TMR Network ERB-FMR XCT 96-0011 and IHP Network HPRN-CT-2000-00014), EPSRC, Pfizer, and Merck

1 reference

12 December 2020

Skeletal diversity via a folding pathway: synthesis of indole alkaloid-like skeletons

1 reference

12 December 2020

Relationship of stereochemical and skeletal diversity of small molecules to cellular measurement space

1 reference

12 December 2020

A General Solution to the Modular Synthesis of Polyketide Building Blocks by Kanemasa Hydroxy-Directed Nitrile Oxide Cycloadditions This work was supported by the ETH-Zürich, Hoffmann-LaRoche, Merck, and Novartis. J.W.B. thanks the National Science

1 reference

12 December 2020

Identifiers

DOI

10.1021/OL070405P

1 reference

25 July 2017

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25 July 2017

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