(Q33296981)

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rs1004819 is the main disease-associated IL23R variant in German Crohn's disease patients: combined analysis of IL23R, CARD15, and OCTN1/2 variants

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Europe PubMed Central

PubMed publication ID

25 July 2017

rs1004819 is the main disease-associated IL23R variant in German Crohn's disease patients: combined analysis of IL23R, CARD15, and OCTN1/2 variants (English)

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Europe PubMed Central

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25 July 2017

Crohn's disease

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Bertram Müller-Myhsok

20

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author name string

Jürgen Glas

1

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25 July 2017

Julia Seiderer

2

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25 July 2017

Martin Wetzke

3

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25 July 2017

Astrid Konrad

4

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25 July 2017

Helga-Paula Török

5

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25 July 2017

Silke Schmechel

6

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25 July 2017

Laurian Tonenchi

7

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25 July 2017

Christine Grassl

8

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25 July 2017

Julia Dambacher

9

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25 July 2017

Simone Pfennig

10

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25 July 2017

Kerstin Maier

11

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25 July 2017

Thomas Griga

12

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25 July 2017

Wolfram Klein

13

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25 July 2017

Jörg T Epplen

14

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25 July 2017

Uwe Schiemann

15

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25 July 2017

Christian Folwaczny

16

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25 July 2017

Peter Lohse

17

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25 July 2017

Burkhard Göke

18

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25 July 2017

Thomas Ochsenkühn

19

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25 July 2017

Matthias Folwaczny

21

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25 July 2017

Thomas Mussack

22

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25 July 2017

Stephan Brand

23

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25 July 2017

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5 September 2007

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25 July 2017

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25 July 2017

2

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25 July 2017

9

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25 July 2017

e819

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25 July 2017

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Creative Commons Attribution 4.0 International

5 September 2007

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Essential autocrine regulation by IL-21 in the generation of inflammatory T cells

1 reference

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IL-21 initiates an alternative pathway to induce proinflammatory T(H)17 cells

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21 June 2018

IL-6 programs T(H)-17 cell differentiation by promoting sequential engagement of the IL-21 and IL-23 pathways

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21 June 2018

Monoclonal Anti–Interleukin 23 Reverses Active Colitis in a T Cell–Mediated Model in Mice

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21 June 2018

IL23R variation determines susceptibility but not disease phenotype in inflammatory bowel disease

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1950565

21 June 2018

Novel Crohn disease locus identified by genome-wide association maps to a gene desert on 5p13.1 and modulates expression of PTGER4

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1950565

21 June 2018

Genome-wide association study identifies new susceptibility loci for Crohn disease and implicates autophagy in disease pathogenesis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1950565

21 June 2018

IL23R Arg381Gln is associated with childhood onset inflammatory bowel disease in Scotland

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1950565

21 June 2018

After interleukin-12p40, are interleukin-23 and interleukin-17 the next therapeutic targets for inflammatory bowel disease?

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1950565

21 June 2018

Dependence of intestinal granuloma formation on unique myeloid DC-like cells.

1 reference

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21 June 2018

IL-23 receptor (IL-23R) gene protects against pediatric Crohn's disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1950565

21 June 2018

A human interleukin-12/23 monoclonal antibody for the treatment of psoriasis

1 reference

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21 June 2018

A large-scale genetic association study confirms IL12B and leads to the identification of IL23R as psoriasis-risk genes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1950565

21 June 2018

IL-22-mediated liver cell regeneration is abrogated by SOCS-1/3 overexpression in vitro

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1950565

21 June 2018

A genome-wide association scan of nonsynonymous SNPs identifies a susceptibility variant for Crohn disease in ATG16L1

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1950565

21 June 2018

Interleukin-22, a T(H)17 cytokine, mediates IL-23-induced dermal inflammation and acanthosis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1950565

21 June 2018

A genome-wide association study identifies IL23R as an inflammatory bowel disease gene

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1950565

21 June 2018

Interleukin-23 drives innate and T cell-mediated intestinal inflammation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1950565

21 June 2018

Mechanisms of Disease: pathogenesis of Crohn's disease and ulcerative colitis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1950565

21 June 2018

Role of the NFKB1 -94ins/delATTG promoter polymorphism in IBD and potential interactions with polymorphisms in the CARD15/NOD2, IKBL, and IL-1RN genes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1950565

21 June 2018

IL-23 is increased in dendritic cells in multiple sclerosis and down-regulation of IL-23 by antisense oligos increases dendritic cell IL-10 production

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1950565

21 June 2018

IL-23 promotes tumour incidence and growth

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1950565

21 June 2018

Immune enhancement and anti-tumour activity of IL-23.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1950565

21 June 2018

IL-23 is essential for T cell-mediated colitis and promotes inflammation via IL-17 and IL-6

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1950565

21 June 2018

TGFbeta in the context of an inflammatory cytokine milieu supports de novo differentiation of IL-17-producing T cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1950565

21 June 2018

Toward an integrated clinical, molecular and serological classification of inflammatory bowel disease: report of a Working Party of the 2005 Montreal World Congress of Gastroenterology

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1950565

21 June 2018

Polymorphisms in the DLG5 and OCTN cation transporter genes in Crohn's disease.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1950565

21 June 2018

CX3CR1-mediated dendritic cell access to the intestinal lumen and bacterial clearance

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1950565

21 June 2018

Anti-interleukin-12 antibody for active Crohn's disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1950565

21 June 2018

Functional variants of OCTN cation transporter genes are associated with Crohn disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1950565

21 June 2018

Constitutive p40 promoter activation and IL-23 production in the terminal ileum mediated by dendritic cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1950565

21 June 2018

Inflammatory Bowel Disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1950565

21 June 2018

A frameshift mutation in NOD2 associated with susceptibility to Crohn's disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1950565

21 June 2018

Association of NOD2 leucine-rich repeat variants with susceptibility to Crohn's disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1950565

21 June 2018

T cell-mediated pathology in two models of experimental colitis depends predominantly on the interleukin 12/Signal transducer and activator of transcription (Stat)-4 pathway, but is not conditional on interferon gamma expression by T cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1950565

21 June 2018

Antibodies to interleukin 12 abrogate established experimental colitis in mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1950565

21 June 2018

Classification of inflammatory bowel disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1950565

21 June 2018

Macrophage migration inhibitory factor (MIF) -173G/C promoter polymorphism influences upper gastrointestinal tract involvement and disease activity in patients with Crohn's disease.

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0000819

21 January 2018

Eight novel CARD15 variants detected by DNA sequence analysis of the CARD15 gene in 111 patients with inflammatory bowel disease

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0000819

21 January 2018

TLR-ligand stimulated interleukin-23 subunit expression and assembly is regulated differentially in murine plasmacytoid and myeloid dendritic cells.

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0000819

21 January 2018

Predictive value of the CARD15 variant 1007fs for the diagnosis of intestinal stenoses and the need for surgery in Crohn's disease in clinical practice: results of a prospective study.

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0000819

21 January 2018

Association between insertion mutation in NOD2 gene and Crohn's disease in German and British populations

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0000819

21 January 2018

IL-6-deficient mice are resistant to experimental autoimmune encephalomyelitis: roles of IL-6 in the activation and differentiation of autoreactive T cells.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1950565

31 October 2018

Cutting edge: IL-23 cross-regulates IL-12 production in T cell-dependent experimental colitis

1 reference

https://pubmed.ncbi.nlm.nih.gov/17786191

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Homozygosity for the CARD15 frameshift mutation 1007fs is predictive of early onset of Crohn's disease with ileal stenosis, entero-enteral fistulas, and frequent need for surgical intervention with high risk of re-stenosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/17786191

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Genetics. Delivering new disease genes

1 reference

https://pubmed.ncbi.nlm.nih.gov/17786191

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The role of Toll-like receptor 4 Asp299Gly and Thr399Ile polymorphisms and CARD15/NOD2 mutations in the susceptibility and phenotype of Crohn's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/17786191

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The Contribution of OCTN1/2 Variants Within the IBD5 Locus to Disease Susceptibility and Severity in Crohn’s Disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/17786191

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Both IL-12p70 and IL-23 are synthesized during active Crohn's disease and are down-regulated by treatment with anti-IL-12 p40 monoclonal antibody

1 reference

https://pubmed.ncbi.nlm.nih.gov/17786191

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Increased expression of the chemokine fractalkine in Crohn's disease and association of the fractalkine receptor T280M polymorphism with a fibrostenosing disease Phenotype

1 reference

https://pubmed.ncbi.nlm.nih.gov/17786191

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

IL-22 is increased in active Crohn's disease and promotes proinflammatory gene expression and intestinal epithelial cell migration

1 reference

https://pubmed.ncbi.nlm.nih.gov/17786191

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

IL-23: a master regulator in Crohn disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/17786191

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

IL-23 is critical in the induction but not in the effector phase of experimental autoimmune encephalomyelitis

1 reference

https://pubmed.ncbi.nlm.nih.gov/17786191

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1371/JOURNAL.PONE.0000819

1 reference

Europe PubMed Central

PubMed publication ID

25 July 2017

2007PLoSO...2..819G

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PMC publication ID

1 reference

Europe PubMed Central

PubMed publication ID

25 July 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

25 July 2017

ResearchGate publication ID

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