(Q33328373)

25 July 2017

Thrombin hydrolysis of human osteopontin is dependent on thrombin anion-binding exosites (English)

1 reference

25 July 2017

Timothy Myles

1

1 reference

PubMed ID

18413297

25 July 2017

Lawrence L K Leung

series ordinal

2

1 reference

PubMed ID

18413297

25 July 2017

language of work or name

English

0 references

publication date

14 April 2008

1 reference

25 July 2017

8

1 reference

Journal of Biological Chemistry

inferred from page(s)

published in

1 reference

25 July 2017

283

1 reference

25 July 2017

26

1 reference

25 July 2017

17789-17796

1 reference

Structural identification of the pathway of long-range communication in an allosteric enzyme

25 July 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2440630

Control of osteopontin signaling and function by post-translational phosphorylation and protein folding

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2440630

Role of osteopontin in neutrophil function

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2440630

Thrombin-cofactor interactions: structural insights into regulatory mechanisms

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2440630

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2440630

Post-translationally modified residues of native human osteopontin are located in clusters: identification of 36 phosphorylation and five O-glycosylation sites and their biological implications

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2440630

The role of Osteopontin in tumor metastasis

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2440630

Molecular mapping of the thrombin-heparin cofactor II complex

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2440630

Phosphorylation-dependent interaction of osteopontin with its receptors regulates macrophage migration and activation.

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2440630

Osteopontin--a molecule for all seasons

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2440630

The influence of the proinflammatory cytokine, osteopontin, on autoimmune demyelinating disease

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2440630

Structural elements of the osteopontin SVVYGLR motif important for the interaction with alpha(4) integrins

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2440630

Enhancement of osteoclastic bone resorption and suppression of osteoblastic bone formation in response to reduced mechanical stress do not occur in the absence of osteopontin

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2440630

Analysis of the alpha4beta1 integrin-osteopontin interaction

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2440630

A regulated interaction between alpha5beta1 integrin and osteopontin

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2440630

Electrostatic dependence of the thrombin-thrombomodulin interaction

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2440630

The integrin alpha(9)beta(1) binds to a novel recognition sequence (SVVYGLR) in the thrombin-cleaved amino-terminal fragment of osteopontin

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2440630

Structural requirements for alpha 9 beta 1-mediated adhesion and migration to thrombin-cleaved osteopontin

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2440630

Casein kinase 2 phosphorylation of recombinant rat osteopontin enhances adhesion of osteoclasts but not osteoblasts

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2440630

Identification of osteopontin as a novel ligand for the integrin alpha8 beta1 and potential roles for this integrin-ligand interaction in kidney morphogenesis

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2440630

Cleavage of the thrombin receptor: identification of potential activators and inactivators

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2440630

Receptor-ligand interaction between CD44 and osteopontin (Eta-1)

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2440630

A player of many parts: the spotlight falls on thrombin's structure.

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2440630

Functional mapping of the surface residues of human thrombin

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2440630

The adhesive and migratory effects of osteopontin are mediated via distinct cell surface integrins. Role of alpha v beta 3 in smooth muscle cell migration to osteopontin in vitro

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2440630

Adhesive properties of osteopontin: regulation by a naturally occurring thrombin-cleavage in close proximity to the GRGDS cell-binding domain

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2440630

Use of site-directed mutagenesis to investigate the basis for the specificity of hirudin.

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2440630

Refined structure of the hirudin-thrombin complex

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2440630

Thrombin is a Na(+)-activated enzyme

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2440630

Electrostatic interactions in the association of proteins: an analysis of the thrombin-hirudin complex

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2440630

The refined 1.9-Å X-ray crystal structure of d-Phe-Pro-Arg chloromethylketone-inhibited human α-thrombin: Structure analysis, overall structure, electrostatic properties, detailed active-site geometry, and structure-function relationships

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2440630

Altered wound healing in mice lacking a functional osteopontin gene (spp1).

28 July 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M708629200

Protein engineering thrombin for optimal specificity and potency of anticoagulant activity in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M708629200

Roles of low specificity and cofactor interaction sites on thrombin during factor XIII activation. Competition for cofactor sites on thrombin determines its fate.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M708629200

An extensive interaction interface between thrombin and factor V is required for factor V activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M708629200

Thrombin activation of factor XI on activated platelets requires the interaction of factor XI and platelet glycoprotein Ib alpha with thrombin anion-binding exosites I and II, respectively

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M708629200

Thrombin interacts with thrombomodulin, protein C, and thrombin-activatable fibrinolysis inhibitor via specific and distinct domains

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M708629200

Functional requirements for inhibition of thrombin by antithrombin III in the presence and absence of heparin

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M708629200

Crystal structure of anticoagulant thrombin variant E217K provides insights into thrombin allostery

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M708629200

Electrostatic steering and ionic tethering in enzyme-ligand binding: insights from simulations

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M708629200

Phosphorylation of osteopontin is required for inhibition of vascular smooth muscle cell calcification

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M708629200

Steady state kinetic parameters for the thrombin-catalyzed conversion of human fibrinogen to fibrin.

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2440630

Essential thrombin residues for inhibition by protein C inhibitor with the cofactors heparin and thrombomodulin

31 October 2018

1 reference

12 December 2020

Cell migration promoted by a potent GRGDS-containing thrombin-cleavage fragment of osteopontin

1 reference

12 December 2020

Electrostatic steering and ionic tethering in the formation of thrombin-hirudin complexes: the role of the thrombin anion-binding exosite-I

1 reference

12 December 2020

Eta-1 (osteopontin): an early component of type-1 (cell-mediated) immunity

1 reference

12 December 2020

Release of fibrinopeptides by the slow and fast forms of thrombin

1 reference

12 December 2020

Osteopontin expression and function: role in bone remodeling

1 reference

12 December 2020

Identification of dual alpha 4beta1 integrin binding sites within a 38 amino acid domain in the N-terminal thrombin fragment of human osteopontin

1 reference

12 December 2020

Activation of human factor V by factor Xa and thrombin

1 reference

12 December 2020

Characterization of the P2' and P3' specificities of thrombin using fluorescence-quenched substrates and mapping of the subsites by mutagenesis

1 reference

12 December 2020

Isolation and biological properties of osteopontin from bovine milk

1 reference

12 December 2020

Structural requirements for the activation of human factor VIII by thrombin

1 reference

12 December 2020

von Willebrand factor is a cofactor for thrombin-catalyzed cleavage of the factor VIII light chain

1 reference

12 December 2020

Use of fragments of hirudin to investigate thrombin-hirudin interaction

1 reference

12 December 2020

Identifiers

DOI

10.1074/JBC.M708629200

1 reference

25 July 2017

1 reference

25 July 2017

1 reference

PubMed ID

18413297