(Q33331870)

English

SPARC promoter hypermethylation in colorectal cancers can be reversed by 5-Aza-2'deoxycytidine to increase SPARC expression and improve therapy response

scientific article

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scholarly article

1 reference

Europe PubMed Central

25 July 2017

SPARC promoter hypermethylation in colorectal cancers can be reversed by 5-Aza-2'deoxycytidine to increase SPARC expression and improve therapy response (English)

1 reference

Europe PubMed Central

25 July 2017

hypermethylation

1 reference

based on heuristic

inferred from title

1 reference

ORCID Public Data File 2021

author name string

S Cheetham

1

1 reference

Europe PubMed Central

25 July 2017

M J Tang

2

1 reference

Europe PubMed Central

25 July 2017

F Mesak

3

1 reference

Europe PubMed Central

25 July 2017

H Kennecke

4

1 reference

Europe PubMed Central

25 July 2017

D Owen

5

1 reference

Europe PubMed Central

25 July 2017

I T Tai

6

1 reference

Europe PubMed Central

25 July 2017

language of work or name

0 references

publication date

6 May 2008

1 reference

Europe PubMed Central

25 July 2017

British Journal of Cancer

1 reference

Europe PubMed Central

25 July 2017

98

1 reference

Europe PubMed Central

25 July 2017

1810-1819

1 reference

Europe PubMed Central

25 July 2017

11

1 reference

Europe PubMed Central

25 July 2017

https://scigraph.springernature.com/pub.10.1038/sj.bjc.6604377

0 references

A novel interaction between procaspase 8 and SPARC enhances apoptosis and potentiates chemotherapy sensitivity in colorectal cancers

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2410109

21 June 2018

Frequent inactivation of SPARC by promoter hypermethylation in colon cancers

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2410109

21 June 2018

Discovery of novel methylation biomarkers in cervical carcinoma by global demethylation and microarray analysis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2410109

21 June 2018

Low or absent SPARC expression in acute myeloid leukemia with MLL rearrangements is associated with sensitivity to growth inhibition by exogenous SPARC protein

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2410109

21 June 2018

Absence of host-secreted protein acidic and rich in cysteine (SPARC) augments peritoneal ovarian carcinomatosis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2410109

21 June 2018

Survey of differentially methylated promoters in prostate cancer cell lines

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2410109

21 June 2018

SPARC expression is associated with impaired tumor growth, inhibited angiogenesis and changes in the extracellular matrix

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2410109

21 June 2018

Genome-wide expression analysis of therapy-resistant tumors reveals SPARC as a novel target for cancer therapy

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2410109

21 June 2018

Array-based analysis of genomic DNA methylation patterns of the tumour suppressor gene p16INK4A promoter in colon carcinoma cell lines

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2410109

21 June 2018

Aberrant methylation of SPARC in human lung cancers

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2410109

21 June 2018

Enhanced growth of pancreatic tumors in SPARC-null mice is associated with decreased deposition of extracellular matrix and reduced tumor cell apoptosis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2410109

21 June 2018

Enhanced growth of tumors in SPARC null mice is associated with changes in the ECM.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2410109

21 June 2018

Doxycycline-inducible expression of SPARC/Osteonectin/BM40 in MDA-MB-231 human breast cancer cells results in growth inhibition

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2410109

21 June 2018

SPARC (secreted protein acidic and rich in cysteine) induces apoptosis in ovarian cancer cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2410109

21 June 2018

SPARC, a matricellular protein that functions in cellular differentiation and tissue response to injury

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2410109

21 June 2018

SPARC, a matricellular protein: at the crossroads of cell-matrix communication

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2410109

21 June 2018

Inactivation of the apoptosis effector Apaf-1 in malignant melanoma

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2410109

21 June 2018

The genetic basis of colorectal cancer: insights into critical pathways of tumorigenesis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2410109

21 June 2018

CpG methylation is maintained in human cancer cells lacking DNMT1.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2410109

21 June 2018

SPARC, a matricellular glycoprotein with important biological functions

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2410109

21 June 2018

CpG island methylator phenotype in colorectal cancer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2410109

21 June 2018

Methylation of the hMLH1 promoter correlates with lack of expression of hMLH1 in sporadic colon tumors and mismatch repair-defective human tumor cell lines

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2410109

21 June 2018

Ki-ras mutations in adenomas: a characteristic of cancer-bearing colorectal mucosa.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2410109

21 June 2018

Lessons from hereditary colorectal cancer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2410109

21 June 2018

Methylation-specific PCR: a novel PCR assay for methylation status of CpG islands

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2410109

21 June 2018

Increased expression of osteonectin and osteopontin, two bone matrix proteins, in human breast cancer.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2410109

21 June 2018

Treatment of acute leukemia with 5-azacytidine (NSC-102816).

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2410109

21 June 2018

Osteonectin/SPARC/BM-40 in human decidua and carcinoma, tissues characterized by de novo formation of basement membrane

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2410109

21 June 2018

SPARC, a secreted protein associated with cellular proliferation, inhibits cell spreading in vitro and exhibits Ca+2-dependent binding to the extracellular matrix

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2410109

21 June 2018

Mutations in the p53 gene occur in diverse human tumour types

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2410109

21 June 2018

The expression of the secreted protein acidic and rich in cysteine (SPARC) is associated with the neoplastic progression of human melanoma.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.BJC.6604377

21 January 2018

Aberrant CpG island hypermethylation of multiple genes in colorectal neoplasia.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.BJC.6604377

21 January 2018

Alteration of DNA methyltransferases contributes to 5'CpG methylation and poor prognosis in lung cancer.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.BJC.6604377

21 January 2018

Microsatellite instability: the mutator that mutates the other mutator

1 reference

https://api.crossref.org/works/10.1038%2FSJ.BJC.6604377

21 January 2018

Bone-related genes expressed in advanced malignancies induce invasion and metastasis in a genetically defined human cancer model.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.BJC.6604377

21 January 2018

5-Aza-2'-deoxycytidine (decitabine) can relieve p21WAF1 repression in human acute myeloid leukemia by a mechanism involving release of histone deacetylase 1 (HDAC1) without requiring p21WAF1 promoter demethylation.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.BJC.6604377

21 January 2018

Synergism between vitamin D and secreted protein acidic and rich in cysteine-induced apoptosis and growth inhibition results in increased susceptibility of therapy-resistant colorectal cancer cells to chemotherapy.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.BJC.6604377

21 January 2018

Increased expression of unmethylated CDKN2D by 5-aza-2'-deoxycytidine in human lung cancer cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.BJC.6604377

21 January 2018

SPARC is a key Schwannian-derived inhibitor controlling neuroblastoma tumor angiogenesis.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2410109

31 October 2018

Evaluation of candidate tumour suppressor genes on chromosome 18 in colorectal cancers

1 reference

https://pubmed.ncbi.nlm.nih.gov/18458674

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Association between CpG island methylation and microsatellite instability in colorectal cancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/18458674

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

p15(INK4B) CpG island methylation in primary acute leukemia is heterogeneous and suggests density as a critical factor for transcriptional silencing

1 reference

https://pubmed.ncbi.nlm.nih.gov/18458674

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Overexpression of SPARC protein contrasts with its transcriptional silencing by aberrant hypermethylation of SPARC CpG-rich region in endometrial carcinoma

1 reference

https://pubmed.ncbi.nlm.nih.gov/18458674

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

SPARC/osteonectin is a frequent target for aberrant methylation in pancreatic adenocarcinoma and a mediator of tumor-stromal interactions

1 reference

https://pubmed.ncbi.nlm.nih.gov/18458674

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Phase II study of 5-azacytidine (NSC-102816) in the treatment of advanced gastrointestinal cancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/18458674

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

5-Azacytidine: a new active agent for the treatment of acute leukemia

1 reference

https://pubmed.ncbi.nlm.nih.gov/18458674

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Phase I study on 5-aza-2′-deoxycytidine in children with acute leukemia

1 reference

https://pubmed.ncbi.nlm.nih.gov/18458674

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The EORTC Early Clinical Trials Cooperative Group experience with 5-aza-2'-deoxycytidine (NSC 127716) in patients with colo-rectal, head and neck, renal carcinomas and malignant melanomas

1 reference

https://pubmed.ncbi.nlm.nih.gov/18458674

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inactivation of the CDKN2/p16/MTS1 gene is frequently associated with aberrant DNA methylation in all common human cancers

1 reference

https://pubmed.ncbi.nlm.nih.gov/18458674

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1038/SJ.BJC.6604377

1 reference

Europe PubMed Central

25 July 2017

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0 references

1 reference

Europe PubMed Central

25 July 2017

1 reference

Europe PubMed Central

25 July 2017

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